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Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines

MEMARIANI, TOKTAM, HOSSEINI, TOKTAM, KAMALI, HOSSEIN, MOHAMMADI, AMENEH, GHORBANI, MARYAM, SHAKERI, ABDOREZA, SPANDIDOS, DEMETRIOS A., TSATSAKIS, ARISTIDIS M., SHAHSAVAND, SHABNAM·2016·Oncology Letters
DOI 10.3892/ol.2015.4050PMC PMC4734339
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Figure 1. Partioning scheme of the methanolic extract. CH2Cl2, dichloromethane; EtOAc, ethyl acetate.
Figure 1. Partioning scheme of the methanolic extract. CH2Cl2, dichloromethane; EtOAc, ethyl acetate.CC BY-NC-ND · PubMed Central
Figure 2. Flow cytometric analysis of the proportion of apoptotic cells. The proportion of apoptotic cells was measured after PI staining of the DNA fragments using flow cytometry. The sub-G1 peak (one of the reliable biochemical markers of apoptosis) was observed at 48 h following treatment of the cells with the extract, the different fractions and the EO of Cyperus longus.
Figure 2. Flow cytometric analysis of the proportion of apoptotic cells. The proportion of apoptotic cells was measured after PI staining of the DNA fragments using flow cytometry. The sub-G1 peak (one of the reliable biochemical markers of apoptosis) was observed at 48 h following treatment of the cells with the extract, the different fractions and the EO of Cyperus longus.CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 49

  1. Katzung, 2012, Basic and Clinical Pharmacology
  2. Shao, 2013, Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263, Mol Cancer Ther, 12, 2640, 10.1158/1535-7163.MCT-13-0066 · DOI
  3. Xu, 2015, Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway, Cancer Cell Int, 15, 25, 10.1186/s12935-015-0166-4 · DOI
  4. Youssef, 2009, Isolation, structural elucidation of flavonoid constituents from Leptadenia pyrotechnica and evaluation of their toxicity and antitumor activity, Pharm Biol, 47, 539, 10.1080/13880200902875065 · DOI
  5. Seelinger, 2008, Anti-carcinogenic effects of the flavonoid luteolin, Molecules, 13, 2628, 10.3390/molecules13102628 · DOI
  6. Samy, 2006, Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats, Chem Biol Interact, 164, 1, 10.1016/j.cbi.2006.08.018 · DOI
  7. Lu, 2015, Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer, J Transl Med, 13, 42, 10.1186/s12967-015-0398-z · DOI
  8. Zhang, 2012, Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines, Food Chem Toxicol, 50, 1589, 10.1016/j.fct.2012.01.025 · DOI
  9. Wang, 2012, Effects of quercetin on the apoptosis of the human gastric carcinoma cells, Toxicol In Vitro, 26, 221, 10.1016/j.tiv.2011.11.015 · DOI
  10. Borska, 2012, In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR, Food Chem Toxicol, 50, 3375, 10.1016/j.fct.2012.06.035 · DOI
  11. Chan, 2013, Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo, PLoS One, 8, e54255, 10.1371/journal.pone.0054255 · DOI
  12. Dixit, 2014, Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice, Med Sci, 2, 153
  13. Chen, 2013, Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis, Scientific World Journal, 29, 26915
  14. Al-Dhabi, 2015, An up-to-date review of rutin and its biological and pharmacological activities, EXCLI J, 14, 59
  15. Slavov, 2013, Biologically active cCompounds with antitumor activity in propolis extracts from different geographic regions, Biotechnol Biotechnol Equip, 27, 4010, 10.5504/BBEQ.2013.0034 · DOI
  16. Sahpazidou, 2014, Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells, Toxicol Lett, 230, 218, 10.1016/j.toxlet.2014.01.042 · DOI
  17. Henderson, 2012, Chemopreventive properties of dietary rice bran: current status and future prospects, Adv Nutr, 3, 643, 10.3945/an.112.002303 · DOI
  18. Abbaszadeh, 2014, Antiangiogenic activity of xanthomicrol and calycopterin, two polymethoxylated hydroxyflavones in both in vitro and ex vivo models, Phytother Res, 28, 1661, 10.1002/ptr.5179 · DOI
  19. Turkez, 2014, Cytotoxic and cytogenetic effects of α-copaene on rat neuron and N2a neuroblastoma cell lines, Biologia, 69, 936, 10.2478/s11756-014-0393-5 · DOI
  20. Costa, 2015, Antitumor properties of the leaf essential oil of Zornia brasiliensis, Planta Med, 81, 563, 10.1055/s-0035-1545842 · DOI
  21. del Hadri, 2010, Cytotoxic activity of α-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells, An R Acad Nac Farm, 76, 343
  22. Saab, 2012, Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants, Planta Med, 78, 1927, 10.1055/s-0032-1327896 · DOI
  23. Babu, 2014, Screening of secondary metabolites of underutilized species of Cyperaceae, Int J Pharm Sci Rev Res, 24, 182
  24. Khamsan, 2011, Antimalarial, anticancer, antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl, Rec Nat Prod, 5, 324
  25. Legault, 2007, Potentiating effect of β-caryophyllene on anticancer activity of α-humulene, isocaryophyllene and paclitaxel, J Pharm Pharmacol, 59, 1643, 10.1211/jpp.59.12.0005 · DOI
  26. Kumar, 2014, Phytochemical analysis and biological properties of Cyperus rotundus L, Ind Crops Prod, 52, 815, 10.1016/j.indcrop.2013.11.040 · DOI
  27. Kilani-Jaziri, 2009, Relationship correlation of antioxidant and antiproliferative capacity of Cyperus rotundus products towards K562 erythroleukemia cells, Chem Biol Interact, 181, 85, 10.1016/j.cbi.2009.04.014 · DOI
  28. Kilani, 2008, In vitro evaluation of antibacterial, antioxidant, cytotoxic and apoptotic activities of the tubers infusion and extracts of Cyperus rotundus, Bioresour Technol, 99, 9004, 10.1016/j.biortech.2008.04.066 · DOI
  29. Morikawa, 2010, Structures of novel norstilbene dimer, longusone A, and three new stilbene dimers, longusols A, B, and C, with antiallergic and radical scavenging activities from Egyptian natural medicine Cyperus longus, Chem Pharm Bull (Tokyo), 58, 1379, 10.1248/cpb.58.1379 · DOI
  30. Harborne, 1971, Distribution and taxonomic significance of flavonoids in the leaves of the cyperaceae, Phytochemistry, 10, 1569, 10.1016/0031-9422(71)85025-2 · DOI
  31. Ait-Ouazzou, 2012, Evaluation of the chemical composition and antimicrobial activity of Mentha pulegium, Juniperus phoenicea, and Cyperus longus essential oils from Morocco, Food Res Int, 45, 313, 10.1016/j.foodres.2011.09.004 · DOI
  32. Xu, 2004, Structures of new sesquiterpenes and hepatoprotective constituents from the Egyptian herbal medicine Cyperus longus, J Nat Prod, 67, 569, 10.1021/np030368k · DOI
  33. Sharma, 2007, Cyperus rotundus extract inhibits acetylcholinesterase activity from animal and plants as well as inhibits germination and seedling growth in wheat and tomato, Life Sci, 80, 2389, 10.1016/j.lfs.2007.01.060 · DOI
  34. Ben-Arye, 2012, Integrative oncology in the Middle East: from traditional herbal knowledge to contemporary cancer care, Ann Oncol, 23, 211, 10.1093/annonc/mdr054 · DOI
  35. Shao, 2013, Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263, Mol Cancer Ther, 12, 2640, 10.1158/1535-7163.MCT-13-0066 · DOI
  36. Apostolou, 2013, Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts, Food Chem Toxicol, 61, 60, 10.1016/j.fct.2013.01.029 · DOI
  37. Androutsopoulos, 2011, Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: Structural requirements for potency, Eur J Med Chem, 46, 2586, 10.1016/j.ejmech.2011.03.049 · DOI
  38. Xue, 2014, Resveratrol oligomers for the prevention and treatment of cancers, Oxid Med Cell Longev, 2014, 765832, 10.1155/2014/765832 · DOI
  39. Parsaee, 2013, Apoptosis Induction of Salvia chorassanica Root Extract on Human Cervical Cancer Cell Line, Iran J Pharm Res, 12, 75
  40. Diao, 2014, Chemical composition, antibacterial activity and mechanism of action of essential oil from seeds of fennel (Foeniculum vulgare Mill.), Food Contr, 35, 109, 10.1016/j.foodcont.2013.06.056 · DOI
  41. Malaekeh-Nikouei, 2013, Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines, Phytother Res, 27, 1868, 10.1002/ptr.4945 · DOI
  42. Mousavi, 2011, Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form, Pharm Biol, 49, 1039, 10.3109/13880209.2011.563315 · DOI
  43. Olaru, 2015, Anticancer potential of selected Fallopia Adans species, Oncol Lett, 10, 1323, 10.3892/ol.2015.3453 · DOI
  44. Boussaada, 2008, Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia, Microbiol Res, 163, 87, 10.1016/j.micres.2007.02.010 · DOI
  45. Rahman, 2008, Antibacterial and Cytotoxic Activity of Longiverbenone Isolated from the Rhizome of Cyperus scariosu, Bangladesh J Microbiol, 25, 82, 10.3329/bjm.v25i1.4866 · DOI
  46. Su, 2007, Terpenoid-related metabolites from a formosan soft coral Nephthea chabrolii, Chem Pharm Bull (Tokyo), 55, 594, 10.1248/cpb.55.594 · DOI
  47. Kamada, 2013, New bioactive secondary metabolites from Bornean red alga, Laurencia similis (Ceramiales), Nat Prod Commun, 8, 287
  48. D'Ambrosio, 2015, Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: Studies on the conformation of viridiflorol, Phytochemistry, 117, 1, 10.1016/j.phytochem.2015.05.005 · DOI
  49. Shao, 2011, Elucidating the toxicity targets of β-ionone on photosynthetic system of Microcystis aeruginosa NIES-843 (Cyanobacteria), Aquat Toxicol, 104, 48, 10.1016/j.aquatox.2011.03.014 · DOI

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Metadata

Authors
MEMARIANI, T., HOSSEINI, T., KAMALI, H., MOHAMMADI, A., GHORBANI, M., SHAKERI, A., SPANDIDOS, D. A., TSATSAKIS, A. M., & SHAHSAVAND, S.
Venue
Oncology Letters
Publisher
Spandidos Publications
Published
2015-12-23
Volume
11
Issue
2
Pages
1353-1360
ISSN
  • 1792-1074
  • 1792-1082
DOI
10.3892/ol.2015.4050
PMC
PMC4734339
Cited by
26
References
0
Language
en

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CoChat. (2026). Citation check: Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines. https://app.cochat.ai/papers/10.3892/ol.2015.4050
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MEMARIANI, T., HOSSEINI, T., KAMALI, H., MOHAMMADI, A., GHORBANI, M., SHAKERI, A., SPANDIDOS, D. A., TSATSAKIS, A. M., & SHAHSAVAND, S. (2016). Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines. Oncology Letters. https://doi.org/10.3892/ol.2015.4050

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