The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma
Open accessAbstract
In a previous study, we found that microRNA (miRNA)-200a suppresses Wnt/β-catenin signaling by interacting with β-catenin, thereby inhibiting migration, invasion and proliferation. However, the mechanism involved in this suppression remains unclear. In the present study, we investigated the underlying mechanism of miR-200a regulation of epithelial-mesenchymal transition (EMT) in gastric carcinoma cells, and confirmed the tumor suppressor role of miR-200a in vivo. The expressions of miRNA-200a, -200b and -200c, identified by fluorescent in situ hybridization, were downregulated and inversely correlated with WHO grades of gastric adenocarcinoma (GA). The expression of the potential miR-200a target genes ZEB1 and ZEB2 was detected immunohistochemically. These examinations used the same tissue microarrays to analyze the relationships between miR-200a and potential target genes. The expression of miR-200a and ZEB1/ZEB2 in the same GA tissue microarrays was inversely related. Restored miR-200a expression inhibited tumor growth in nude mice harboring subcutaneous SGC7901 xenografts. The expression of N-cadherin, β-catenin, Twist1 and Snail2 decreased, and E-cadherin levels increased, when miR-200a was elevated, as tested by fluorescence microscopy and immunohistochemistry. Similar results were observed in vivo. We found upregulated miR-200a expression to increase E-cadherin and suppress the Wnt/β-catenin pathway by targeting ZEB1 and ZEB2 in GA, thus delaying tumor growth in vivo. The effect of miR-200a on Wnt/β-catenin signaling may provide a therapeutic target against EMT.
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Cites
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272
Cited by
Emami Nejad, A., Najafgholian, S., Rostami, A., Sistani, A., Shojaeifar, S., Esparvarinha, M., Nedaeinia, R., Haghjooy Javanmard, S., Taherian, M., Ahmadlou, M., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-020-01719-5 · Cited by 693
Yang, X.-Z., Cheng, T.-T., He, Q.-J., Lei, Z.-Y., Chi, J., Tang, Z., Liao, Q.-X., Zhang, H., Zeng, L.-S., & Cui, S.-Z. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0874-1 · Cited by 386
The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer
Peng, Y., Zhang, X., Feng, X., Fan, X., & Jin, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.12923 · Cited by 149
You, J., Li, Y., Fang, N., Liu, B., Zu, L., Chang, R., Li, X., & Zhou, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091827 · Cited by 91
Metadata
- Authors
- CONG, N., DU, P., ZHANG, A., SHEN, F., SU, J., PU, P., WANG, T., ZJANG, J., KANG, C., & ZHANG, Q.
- Venue
- Oncology Reports
- Publisher
- Spandidos Publications
- Published
- 2013-01-31
- Volume
- 29
- Issue
- 4
- Pages
- 1579-1587
- ISSN
- 1021-335X (ISSN-L)
- 1791-2431
- OpenAlex
- W1985450307
- Cited by
- 160
- References
- 2
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- CoChat. (2026). Citation check: Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. https://app.cochat.ai/papers/10.3892/or.2013.2267
- The paper
- CONG, N., DU, P., ZHANG, A., SHEN, F., SU, J., PU, P., WANG, T., ZJANG, J., KANG, C., & ZHANG, Q. (2013). Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncology Reports. https://doi.org/10.3892/or.2013.2267
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