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Cited by 693Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisAngiogenesis and VEGF in Cancer

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

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Emami Nejad, Asieh, Najafgholian, Simin, Rostami, Alireza, Sistani, Alireza, Shojaeifar, Samaneh, Esparvarinha, Mojgan, Nedaeinia, Reza, Haghjooy Javanmard, Shaghayegh +5 more·2021·Cancer Cell International
DOI 10.1186/s12935-020-01719-5PMC PMC7816485
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Abstract

Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; increase survival of tumor, as well as suppress anti-tumor immunity and hamper the therapeutic response. Hypoxia mediates these effects by several potential mechanisms: altering gene expression, the activation of oncogenes, inactivation of suppressor genes, reducing genomic stability and clonal selection. We have reviewed the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment (TME), highlighting the potential use of cancer stem cells in tumor treatment.

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  • Suppression of hypoxia-driven angiogenesis and metabolic plasticity is desirable in pathological settings such as solid tumors and pathological neovascular eye conditions.

    “In contrast, suppression of hypoxia-driven angiogenesis and metabolic plasticity is desirable in pathological settings such as solid tumors [[18], [19], [20]] and pathological neovascular eye conditions”

    From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [19]

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Authors
Emami Nejad, A., Najafgholian, S., Rostami, A., Sistani, A., Shojaeifar, S., Esparvarinha, M., Nedaeinia, R., Haghjooy Javanmard, S., Taherian, M., Ahmadlou, M., Salehi, R., Sadeghi, B., & Manian, M.
Affiliations
  • Arak University of Medical Sciences (IR)
  • Tabriz University of Medical Sciences (IR)
  • Isfahan University of Medical Sciences (IR)
  • Iran University of Medical Sciences (IR)
Corresponding author
  • Sadeghi, Bahman
  • Manian, Mostafa
ORCID
Venue
Cancer Cell International
Publisher
Springer Science and Business Media LLC
Published
2021-01-20
Volume
21
Issue
1
Pages
62-62
ISSN
1475-2867 (ISSN-L)
DOI
10.1186/s12935-020-01719-5
PMC
PMC7816485
OpenAlex
W3121420611
Cited by
693
References
33
Citations by year
2026: 82 · 2025: 157 · 2024: 157 · 2023: 159 · 2022: 106 · 2021: 32
FWCI
13.69
Type
journal article
Language
en
Open access
Licence
Locations
  • Cancer Cell International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
tumor hypoxia, tumor microenvironment, cancer stem cells, angiogenesis, metastasis, antitumor immunity, oncogene activation, tumor suppressor, genomic instability, clonal selection, cancer therapy

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