Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

YUAN, YAO, JIANG, YU-CHEN, SUN, CHONG-KUI, CHEN, QIAN-MING·2016·Oncology Reports

Cited by (321)

Items 201–300 of 321

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  5. Innovative optical imaging strategies for monitoring immunotherapy in the tumor microenvironments
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  6. Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer
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  7. An Immune-Related Prognostic Classifier Is Associated with Diffuse Large B Cell Lymphoma Microenvironment
    Xiaojie Liang, Ruiying Fu, He-nan Wang, Jing Yang, Na Yao, Xindi Liu, Liang Wang · 2021 · Journal of Immunology Research
  8. Heterogeneous effects of M‐ CSF isoforms on the progression of MLL ‐ AF 9 leukemia
    Rong Wang, Wenli Feng, Feifei Yang, Xiao Qi Yang, Lina Wang, Chong Chen, Yuting Hu, Qian Ren, Guoguang Zheng · 2017 · Immunology and Cell Biology
  9. Immunological and vascular characteristics in cavernous sinus meningioma
    Kenzo Kosugi, Ryota Tamura, Kentaro Ohara, Yukina Morimoto, Yuki Kuranari, Yumiko Oishi, Kazunari Yoshida, Masahiro Toda · 2019 · Journal of Clinical Neuroscience
  10. Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer
    Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn et al. · 2023 · Frontiers in Oncology
  11. Knockout cancer by nano-delivered immunotherapy using perfusion-aided scaffold-based tumor-on-a-chip
    Pooja Suryavanshi, Dhananjay Bodas · 2024 · Nanotheranostics
  12. Machine learning predictions of tumor progression: How reliable are we?
    Molham Sakkal, Abdallah Abou Hajal · 2025 · Computers in Biology and Medicine
  13. Nuclear Expression of CD133 Is Associated with Good Prognosis in Patients with Colorectal Adenocarcinoma
    Yong‐Moon Lee, Min‐Kyung Yeo, In‐Ock Seong, Kyung‐Hee Kim · 2018 · Anticancer Research
  14. Anaesthesia and cancer: can anaesthetic drugs modify gene expression?
    Aida Raigón Ponferrada, José Luis Guerrero Orriach, Alfredo Malo-Manso, Enrique Sepúlveda Haro, Salvador Romero Molina, Ana Fontaneda Heredia, Manolo Baena Lopez, José Cruz Mañas · 2020 · ecancermedicalscience
  15. Cancer chemoresistance and therapeutic strategies targeting tumor microenvironment
    Gayathri Heenatigala Palliyage, Rajib Ghosh, Yon Rojanasakul · 2020 · ScienceAsia
  16. Pan-cancer analysis of PSAP identifies its expression and clinical relevance in gastric cancer
    Zhenpeng Wen, Chunjiao Yang, Dan Zou, Jiaqing Liu, Song Wang, Xuqin Liu, Yi Zhang, Ye Zhang · 2022 · Pathology - Research and Practice
  17. 3D-culture models as drug-testing platforms in canine lymphoma and their cross talk with lymph node-derived stromal cells
    Ju‐Hyun An, Woo‐Jin Song, Qiang Li, Dong Ha Bhang, Hwa‐Young Youn · 2021 · Journal of Veterinary Science
  18. Disrupting stromal barriers to enhance photothermal-chemo therapy using a halofuginone-loaded Janus mesoporous nanoplatform
    Rui Tang, Meng Dang, Xiaojun Zhang, Jun Tao, Wenhui Shi, Wei Ming Lu, Ruifa Yu, Xiaodan Su, Yuxia Tang, Zhaogang Teng · 2021 · Journal of Colloid and Interface Science
  19. Receptor, Signal, Nucleus, Action: Signals That Pass through Akt on the Road to Head and Neck Cancer Cell Migration
    Albashir Alzawi, Anem Iftikhar, Basher Shalgm, Sarah Jones, Ian Ellis, Mohammad R Islam · 2022 · Cancers
  20. SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma
    Bin Li, Meiyu Ren, Yuzhen Chen, Yuqi Meng, Tie‐Niu Song, Zhipeng Su, Bo Yang · 2022 · The Journal of Gene Medicine
  21. Strategies for cancer therapy
    Abeer Hamed Abdel-Halim · 2023 · Egyptian Pharmaceutical Journal
  22. The role of CXCL1 in crosstalk between endocrine resistant breast cancer and fibroblast
    Sneha Pandithar, Daniel Galke, Ahone Akume, Artem Belyakov, Dominick Lomonaco, Amirah A. Guerra, Jay Park, Olivia Reff, Kideok Jin · 2024 · Molecular Biology Reports
  23. A novel approach for transforming breast cancer stem cells into endothelial cells
    Qi-Qi Mao, Xiao-Chun Ji, Jianan Zhang, Wei-Feng Teng, Shaocheng Zhou · 2023 · Experimental and Therapeutic Medicine
  24. Evaluation of tumor response to immune checkpoint inhibitors by a 3D immunotumoroid model
    Abdulmohammad Pezeshki, John C. Cheville, Angela B. Florio, Bradley C. Leibovich, George Vasmatzis · 2024 · Frontiers in Immunology
  25. Tensile force field plays a crucial role in local invasion of tumor cells through a mechano-chemical coupling mechanism
    Jianfeng Meng, Xiangyu Xu, Chaohui Jiang, Peng Xia, Pengfei Xu, Liangfei Tian, Yingke Xu, Dechang Li, Youhua Tan, Baohua Ji · 2024 · Soft Matter
  26. The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair
    Whitney M. Longmate · 2024 · Matrix Biology
  27. The effect of cancer cell-derived exosomal proteins on macrophage polarization: An in-depth review
    Khandu Wadhonkar, Soumalya Das, R. Subramanian, Mobbassar Hassan Sk, Yashi Singh, Mirza S. Baig · 2024 · Experimental Cell Research
  28. Single-cell transcriptomic analyses provide insights into the tumor microenvironment heterogeneity and invasion phenotype in retinoblastoma
    Xiaoliang Zhang, Hong Liu, Zhida Lan, Guangping Gao, Guanyu Li, Ziwei Dai, Shangyao Qin, Wei Shen · 2025 · Pathology - Research and Practice
  29. Identification of WDFY3 Neoantigens as Prognostic Markers in Longterm Survivors of Extrahepatic Cholangiocarcinoma
    Yingyi Wang, Bao Jin, Na Zhou, Zhao Sun, Jiayi Li, Qiao Chen, Xiangan Wu, Yi Zhou, Yue Xi Shi, Xin Lu et al. · 2020 · Current Cancer Drug Targets
  30. Immune Subtype Profiling and Establishment of Prognostic Immune-Related lncRNA Pairs in Human Ovarian Cancer
    Xingling Wang, Jing Wang, Mingxin Yu · 2022 · Computational and Mathematical Methods in Medicine · Retracted
  31. ImReLnc: Identifying Immune-Related LncRNA Characteristics in Human Cancers Based on Heuristic Correlation Optimization
    Meihong Gao, Shuhui Liu, Qi Yang, Xinpeng Guo, Xuequn Shang · 2022 · Frontiers in Genetics
  32. Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization
    Mingjun Yang, Wen Zhou, Mingming Xu, Xiao Lian Han, Yanyan Shi, Min Shi, Zhipeng Wang · 2023 · Journal of Oncology
  33. An Immune Gene Signature Stratifies Breast Cancer Prognosis Through iCAF-Driven Immunosuppressive Microenvironment
    Sibin Mei, Chenhao Bai, Huijuan Wang, Kainan Lin, Tianyuan Pan, Yunkun Lu, Qian Cao · 2025 · Biomedicines
  34. A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing
    Karina Benderski, Paul M. Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli‐Öztürk, Fabian M. Kiessling et al. · 2024 · Pharmacological Research
  35. Dauriporphine inhibited lung cancer cell viability, motility, and energy metabolism through the miR-424-5p/MAPK14 axis
    Yanjia Du, Jinpeng Lv, Yao Shi Fu, Meng Lan, Jingfeng Li, Hui Zhang, Nan Wu · 2025 · Hereditas
  36. The Role of Fibroblasts in Melanoma Development: From Tumor Microenvironment Remodeling to Pre-Metastatic Niche Formation
    Immacolata Belviso, Raffaele Pastore, Aldo Mileo, Emiliano Del Genio, Stefania Boccia, Stefano Palermi, Carmine Sellitto, Maria Letizia Motti · 2025 · International Journal of Molecular Sciences
  37. Transcriptomic analysis of stromal cells from patients with endometrial carcinoma.
    Min Li, Xiaoyan Xin, Zhishan Jin, Hua Teng, Hongbin Wang, Hongbo Wang · 2017 · PubMed Central
  38. Mesothelioma Mouse Models with Mixed Genomic States of Chromosome and Microsatellite Instability
    Yurong Song, Shaneen S. Baxter, Lisheng Dai, Chelsea Sanders, Sandra Sczerba Burkett, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Simone Difilippantonio et al. · 2022 · Cancers
  39. Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway
    Yaqiong Zhang, Bo Li, Wanhong Gu, Linna Fan, Xiao‐Fan Wang, Meifen Xu, Minqi Zhu, Chong Jin · 2025 · Discover Oncology
  40. Novel Biological Strategies for Melanoma Therapy: A Focus on lncRNAs and Their Targeting
    Francesca Maria Orlandella, Rosaria Arcone, Neila Luciano, Giuliana Salvatore, Maria Letizia Motti · 2025 · Cancers
  41. Lipoproteins and the Tumor Microenvironment
    Akpedje Serena Dossou, Nirupama A. Sabnis, Bhavani Nagarajan, Ezek Mathew, Rafał Fudala, Andras G. Lacko · 2020 · Advances in experimental medicine and biology
  42. Dual therapeutic strategy targeting tumor cells and tumor microenvironment in triple-negative breast cancer
    Tsu‐Yi Chao, Pamungkas Bagus Satriyo, Chi‐Tai Yeh, Jia-Hong Chen, Teguh Aryandono, Sofia Mubarika Haryana · 2020 · Journal of Cancer Research and Practice
  43. Targeting tumor microenvironment for breast cancer treatment
    Manzoor Ahmad Mir, Burhan Ul Haq · 2022 · Elsevier eBooks
  44. Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review
    Anirban Ganguly, Sumit Mukherjee, Kaushiki Chatterjee, Sheila Spada · 2024 · International review of cytology
  45. Antineoplastic drug‐loaded polymer‐modified magnetite nanoparticles: Comparative analysis of EPR‐mediated drug delivery
    Amaneh Javid, Madiha Javeed Ghani, Sughra Shahzad, Saeed Rezaei‐Zarchi · 2020 · Cell Biology International
  46. CNPY2 in Solid Tumors: Mechanisms, Biomarker Potential, and Therapeutic Implications
    Sayan Mullick Chowdhury, Feng Hong, Christian Diego Rolfo, Zihai Li, Kai He, Robert Wesolowski, Amir Mortazavi, Lingbin Meng · 2025 · Biology
  47. Tumor Microenvironment in Cancer Biology: A Comprehensive Review of Stromal, Immune, and Vascular Components Driving Malignancy
    Sushma T A, Sudarshan Gupta, Priyanka Kiyawat, Yashodha Darshan, Kumar Sambhav, Saiyad Shabbirali Shamshadali · 2025 · Cureus
  48. Regular Voluntary Running is Associated with Increased Tumor Vascularization and Immune Cell Infiltration and Decreased Tumor Growth in Mice
    Mário Esteves, Carina Silva, António Bovolini, Sofia Silva Pereira, Tiago Morais, Ângela Moreira, Madalena M Costa, Mariana Pereira Monteiro, José Alberto Duarte · 2023 · International Journal of Sports Medicine
  49. Tumour immune microenvironment as the origin of heterotypic circulating tumour cell clusters and their impact on metastasis: An hypothesis
    Geeta S. Boora, Anshika Chauhan, Arnab Pal · 2023 · Medical Hypotheses
  50. Thermo-Responsive Hydrogel Based on Lung Decellularized Extracellular Matrix for 3D Culture Model to Enhance Cancer Stem Cell Characteristics
    Lei Chen, Fanglu Li, Ruobing Li, Ke Zheng, Xinyi Zhang, Huijing Ma, Kaiming Li, Lei Nie · 2024 · Molecules
  51. Polymeric mixed micelles with triple stimuli-responsive characteristics and förster resonance energy transfer phenomenon for drug delivery system of chemotherapy and photodynamic therapy
    Hong‐Jia Lin, Li-Xuan Hong, Wen‐Chung Wu · 2025 · Journal of Polymer Research
  52. High-Throughput Microenvironment Microarray (MEMA) High-Resolution Imaging
    Tiina A. Jokela, Michael E. Todhunter, Mark A. LaBarge · 2022 · Methods in molecular biology
  53. The Correlation between YAP and RhoA Expression in Prostate and Ovarian Tumor Stroma
    Myung-Jin Lee, Dokyeong Kim · 2022 · Asian Pacific Journal of Cancer Prevention
  54. Extracellular Vesicles as Biomarkers and Therapeutic Targets in Cancers
    Prince Amoah Barnie, Justice Afrifa, Eric Ofori Gyamerah, Benjamin Amoani · 2022 · Physiology
  55. A primer on metabolic contributions in tumor angiogenic microenvironment
    Ma Carmen Ocaña, Manuel Bernal, Ana R. Quesada, Miguel Ángel Medina · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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    Xiang Gao, Wenzhao Wang, Mingjie Sun, Hongxiang Zhao, Zhuo Shang, Alice S.T. Wong, Yunshan Wang, Miaoqing Zhao, Duanrui Liu · 2026 · Biomedical Technology
  57. Reprogramming of Tumor Associated Immune Cells by Phytochemicals: In-vitro Approaches for Cancer Treatment
    Pradip Kumar Jaiswara, Vishal Kumar Gupta, Shiv Govind Rawat, Pratishtha Sonker, Ajay Kumar · 2019 · Springer eBooks
  58. Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression
    Victor V. Pleshkan, Marina V. Zinovyeva, Dina V. Antonova, И. В. Алексеенко · 2023 · Biomedicines
  59. Correlation of Radiomics with Treatment Response in Liver Metastases
    Leila Mostafavi, Fatemeh Homayounieh, Félix Lades, Andrew N. Primak, Victorine V. Muse, Gordon J. Harris, Mannudeep K. Kalra, Subba Rao Digumarthy · 2023 · Academic Radiology
  60. DEP domain containing 1 as a biomarker for poor prognosis in lung adenocarcinoma
    Cuixian Li, Xiaoling Zhu · 2024 · Heliyon
  61. Vol 15 Issue 1 Tumor Microenvironment-Different Cells and Functions in the Metastasis and Progression of Cancer
    Maryam Musleh Althobiti · 2024 · International Journal of Pharmaceutical Investigation
  62. Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer
    Hye Sung Won, Yong-Seok Kim, Kyung Jin Seo, Sun‐Young Jun, Der Sheng Sun, Mihong Choi, Jung‐Sook Yoon, Jae Ho Byun · 2025 · Frontiers in Oncology
  63. The role of the tumor microenvironment in the metastasis of pancreatic cancer and immunotherapy
    Şermin Tetik, Nilgün Tekkeşin · 2019 · Elsevier eBooks
  64. Roles for Integrin α3β1 in Development and Disease
    C. Michael DiPersio, Whitney M. Longmate · 2023 · Biology of extracellular matrix
  65. Single-Cell Multiomics: Dissecting Cancer
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  66. Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Platycodonis radix inhibits tumor
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  67. Smart materials in pharmacological drug development: Neutrophils and its constituents for drug delivery and consequent antitumor effects
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  70. TMT1A inhibits lung adenocarcinoma progression by suppressing M2 macrophage polarization
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  72. Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions
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  73. THE CONTRIBUTION OF LACTATE AND PHOSPHATE ANIONS TO THE BUFFER PROPERTIES OF TISSUE HOMOGENATES OF BREAST ADENOCARCINOMA
    Margarita Barsukova, Yekaterina Khomutova, Yevgeniy Khomutov · 2019 · Voprosy Onkologii
  74. Intercellular interactions in the tumor stroma and their role in oncogenesis
    Nataliya A. Lunina, Dina R. Safina · 2022 · Molecular Genetics Microbiology and Virology (Russian)
  75. Proteasome Subunit Alpha Type-7 Expression Suppresses Cutaneous Squamous Cell Carcinoma Progression by Inhibiting Cancer-associated Cytokines
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  76. Engineering global and local signal generators for probing temporal and spatial cellular signaling dynamics
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  77. Inhibitory effect of recombinant tyrosine‑sulfated madanin‑1, a thrombin inhibitor, on the behavior of MDA‑MB‑231 and SKOV3 cells in vitro
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  78. Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia
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  79. Resistance to Checkpoint Blockade Inhibitors and Immunomodulatory Drugs
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  80. ANKDD1A may serve as a critical gene in the immune microenvironment of breast cancer
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  81. Potential use of absorbance scanning in differentiating tumor microenvironment compositions from endoscopic biopsy of colorectal cancer patients.
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  82. Consistency Analysis of CTLM Imaging and Mammography in the Diagnosis of Breast Tumor Lesions
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  83. RETRACTED ARTICLE: Development of new c-Met inhibitors and application of corresponding multitarget tyrosine kinase inhibitors in tumor therapy
    Xiangcong Zeng, Yuanwen Hu, Zhi Peng Xu, Xiaoyu O. Wu, Yun Xiong, Shengpeng Liu · 2023 · Soft Computing · Retracted
  84. CHEMOTHERAPY-INDUCED PDL-1 EXPRESSION IN CANCER-ASSOCIATED FIBROBLASTS PROMOTES CHEMORESISTANCE IN NSCLC
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  85. MATHEMATICAL MODELING AND OPTIMIZATION OF TARGETED TUMOR THERAPY
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  86. Importancia de la investigación sobre el estroma tumoral en el cáncer de mama
    Noemí Eiró, Sandra Cid, María Fraile, Francisco José Vizoso · 2019 · Revista de Senología y Patología Mamaria
  87. Development of artificial cell culture platforms using microfluidics
    Hande Karamahmutoğlu · 2019 · Sabanci University
  88. Variable Tumor Microenvironment-on-a-chip with Temporal Angiogenic Switching System by Diffusion Control
    SungHyun Cho, Hyung Seok Choi, Jung Eun Yang, SeungBeum Suh · 2020 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
  89. Strategies for targeted and image-guided drug delivery to tumor
    Ayele H. Negussie · 2021
  90. Papel de ADAMTS-1 nuclear em células normais e tumorais.
    Suély Vieira da Silva · 2020
  91. SYNGR2 Serves as a Prognostic Biomarker and Correlated with Immune Infiltrates in Esophageal Squamous Cell Carcinoma
    Bin Li, Meiyu Ren, Yuzhen Chen, Yuqi Meng, Tie‐Niu Song, Zhipeng Su, Bo Yang · 2022 · Research Square
  92. Faculty Opinions recommendation of Roles of circRNAs in the tumour microenvironment.
    Sabine Müller · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  93. Designing injectable and autoclavable cryogel scaffolds for tissue engineering and tumor/tissue reconstruction
    Mahboobeh Rezaeeyazdi · 2019
  94. Functional roles of EMP-associated targets in breast cancer models
    Alan Kie Leong Toh · 2021 · Queensland University of Technology
  95. Tumor Associated Macrophages: Evolutionary Role in Cancer Therapeutics
    Fouzia Fazal, Muhammad Arsalan Khan, Sumayya Shawana, Muhammed Mubarak · 2022 · Journal of Bahria University Medical and Dental College
  96. Resposta do tratamento com metformina e do exercício físico aeróbio na mitigação dos distúrbios musculares induzidos pela doxorrubicina.
    Edson Alves de Lima · 2020
  97. Prognostic significance of Cyclooxygenase-2 expression in colorectal adenoma and Adenocarcinoma: A clinicopathologic study
    Noor I. Ibrahim, Shazana Hilda Shamsuddin, Suk K. Lee, Sharifah Emilia Tuan Sharif · 2023 · Human Pathology Reports
  98. Intercellular Interactions in the Tumor Stroma and Their Role in Oncogenesis
    Nataliya A. Lunina, Dina R. Safina · 2022 · Molecular Genetics Microbiology and Virology
  99. Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer
    Zhimin Tao, Bo Li, Chunyan Kang, Wei Wang, Xianzhe Li, Yaowu Du · 2023 · Discover Oncology
  100. A expressão dos marcadores de transição epitélio-mesenquimal SNAI1 e o ZEB1 resulta em alterações transcricionais para promover progressão tumoral e evasão imune no câncer de próstata
    Luiz Paulo Chaves · 2023