Cited by 352Reproductive System and PregnancySystemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Low Molecular Weight Heparin and Aspirin for Recurrent Pregnancy Loss: Results from the Randomized, Controlled HepASA Trial

Open access

LASKIN, CARL A., SPITZER, KAREN A., CLARK, CHRISTINE A., CROWTHER, MARK R., GINSBERG, JEFF S., HAWKER, GILLIAN A., KINGDOM, JOHN C., BARRETT, JON, GENT, MICHAEL·2009·The Journal of Rheumatology

DOI 10.3899/jrheum.080763

Open this paper in CoChat — free account Open PDF

Abstract

Objective.: To compare live birth rates in women with recurrent pregnancy loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with similar cohorts. Methods.: The HepASA Trial was an RCT including patients with a history of RPL and at least 1 of the following: antiphospholipid antibody (aPL), an inherited thrombophilia, or antinuclear antibody. Treatment groups were stratified by aPL status and history of early versus late pregnancy losses. Patients received either LMWH/ASA or ASA alone. The primary outcome was live birth; secondary outcomes included adverse events and bone loss at the spine and femoral neck. Literature over the past 20 years was reviewed to identify comparable RCT. Results.: Over 4 years, 859 women with RPL were screened: 88 (10.2%) fulfilled inclusion criteria, became pregnant and were randomized to receive either LMWH/ASA or ASA alone. aPL were present in 42 (47.7%) patients in each group. The trial was stopped after 4 years when an interim analysis showed no difference in live birth rates in the 2 groups, and a lower rate of pregnancy loss in the ASA only group than expected. In the LMWH/ASA group, 35/45 (77.8%) had a live birth versus 34/43 (79.1%) in the ASA only group (p = 0.71). Neither number of prior losses nor aPL status was correlated with pregnancy outcome. There were no cases of pregnancy related thrombosis in either group. Mean change in BMD did not differ by treatment group at either the lumbar spine (p = 0.57) or femoral neck (p = 0.15). RCT since 2000 for aPL positive women with RPL and similar inclusion criteria report a mean live birth rate of 75% with either LMWH or ASA. Conclusion.: LMWH/ASA did not confer incremental benefit compared to ASA alone for this population. Regardless of treatment regimen, number of prior losses, or aPL positivity, almost 80% of women in our RPL cohort had a successful pregnancy outcome. These findings contribute to a growing body of literature that contests the emerging standard of care comprising LMWH/ASA for this population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3899/jrheum.080763

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
Incidence of early loss of pregnancy
Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354
A New and Improved Population-Based Canadian Reference for Birth Weight for Gestational Age
Kramer, M. S., Platt, R. W., Wen, S. W., Joseph, K. S., Allen, A. C., Abrahamowicz, M., Blondel, B., Bréart, G., & Bréart, G. (2001) · PEDIATRICS · doi:10.1542/peds.108.2.e35 · Cited by 1,526
Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
Rai, R., Cohen, H., Dave, M., & Regan, L. (1997) · BMJ · doi:10.1136/bmj.314.7076.253 · Cited by 1,113
Thrombophilic disorders and fetal loss: a meta-analysis
Rey, E., Kahn, S. R., David, M., & Shrier, I. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12771-7 · Cited by 872
Antiphospholipid antibody–associated recurrent pregnancy loss: Treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone
Kutteh, W. H. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70610-5 · Cited by 807
Increased fetal loss in women with heritable thrombophilia
Preston, F., Rosendaal, F., Walker, I., Briët, E., Berntorp, E., Conard, J., Fontcuberta, J., Makris, M., Mariani, G., Noteboom, W., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)04125-6 · Cited by 661
Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment
Cowchock, F. S., Reece, E. A., Balaban, D. J., Branch, D. W., & Plouffe, L. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91596-3 · Cited by 585
Pregnancy Loss in the Antiphospholipid-Antibody Syndrome — A Possible Thrombogenic Mechanism
Rand, J. H., Wu, X.-X., Andree, H. A. M., Lockwood, C. J., Guller, S. M., Scher, J., & Harpel, P. C. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707173370303 · Cited by 519
Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
Empson, M. B., Lassere, M., Craig, J. C., & Scott, J. R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002859.pub2 · Cited by 486

Flagged first, then by citations

Show all 43 references

Research works printed but not linked: 3

Carson SA Branch DW . ACOG Practice Bulletin 24. Management of recurrent early pregnancy loss. 2002 Compendium of Selected Publications. Washington, DC: American College of Obstetricians and Gynecologists; 2001:372–83.
Ramsay Goldman, 1988, Pregnancy in systemic lupus erythematosus, Rheum Dis Clin North Am, 14, 169, 10.1016/S0889-857X(21)00953-4 · DOI
Spitzer, 2002, Prevalence of inherited thrombophilias in women with unexplained recurrent pregnancy loss, Arthritis Rheum, 46, S231

Sorted by citations

VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy
Bates, S. M., Greer, I. A., Middeldorp, S., Veenstra, D. L., Prabulos, A.-M., & Vandvik, P. O. (2012) · Chest · doi:10.1378/chest.11-2300 · Cited by 1,525
EULAR recommendations for the management of antiphospholipid syndrome in adults
Tektonidou, M. G., Andreoli, L., Limper, M., Amoura, Z., Cervera, R., Costedoat-Chalumeau, N., Cuadrado, M. J., Dörner, T., Ferrer-Oliveras, R., Hambly, K., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215213 · Cited by 1,318
Antiphospholipid syndrome
Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 875
Self-citation
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
Empson, M. B., Lassere, M., Craig, J. C., & Scott, J. R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002859.pub2 · Cited by 486
Antiphospholipid syndrome
Schreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 445
Factor V Leiden thrombophilia
Kujovich, J. L. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181faa0f2 · Cited by 422
Recurrent Miscarriage
Branch, D. W., Gibson, M., & Silver, R. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1005330 · Cited by 339
Venous Thromboembolism and Antithrombotic Therapy in Pregnancy
Chan, W., Rey, É., Kent, N., Chan, W., Kent, N., Rey, É., Corbett, T., David, M., Douglas, M. J., Gibson, P., et al. (2014) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(15)30569-7 · Cited by 315
Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management
Knight, J. S., Branch, D. W., & Ortel, T. L. (2023) · BMJ · doi:10.1136/bmj-2021-069717 · Cited by 299
Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial
Rodger, M. A., Hague, W. M., Kingdom, J. C., Kahn, S. R., Karovitch, A. J., Sermer, M., Clement, A. M., Coat, S., Chan, W., Said, J. M., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60793-5 · Cited by 256
Self-citation
Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression
Mak, A., Cheung, M. W. ‐., Cheak, A. A.-C., & Ho, R. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep373 · Cited by 253
Low-molecular-weight heparin and recurrent placenta-mediated pregnancy complications: a meta-analysis of individual patient data from randomised controlled trials
Rodger, M. A., Gris, J., de Vries, J. I. P., Martinelli, I., Rey, É., Schleußner, E., Middeldorp, S., Kaaja, R., Langlois, N. J., Ramsay, T., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31139-4 · Cited by 228
Low‐molecular‐weight heparin added to aspirin in the prevention of recurrent early‐onset pre‐eclampsia in women with inheritable thrombophilia: the FRUIT‐RCT
de Vries, J. I. P., van Pampus, M. G., Hague, W. M., Bezemer, P. D., & Joosten, J. H. K. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04553.x · Cited by 213
Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia
de Jong, P. G., Kaandorp, S., Di Nisio, M., Goddijn, M., & Middeldorp, S. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004734.pub4 · Cited by 204
Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial
Schisterman, E. F., Silver, R. M., Lesher, L. L., Faraggi, D., Wactawski‐Wende, J., Townsend, J. M., Lynch, A. M., Perkins, N. J., Mumford, S. L., & Galai, N. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60157-4 · Cited by 209
Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy
Lefkou, E. E., Mamopoulos, A. M., Dagklis, T., Vosnakis, C., Rousso, D., & Girardi, G. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86957 · Cited by 192
Diagnosis and management of the antiphospholipid syndrome
Chaturvedi, S., & McCrae, K. R. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.07.006 · Cited by 195
14th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome
de Jesús, G. R., Agmon‐Levin, N., de Andrade, C. A. F., Andréoli, L., Chighizola, C. B., Porter, T. F., Salmon, J. E., Silver, R. M., Tincani, A., & Branch, D. W. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.02.003 · Cited by 187
Heparin Treatment in Antiphospholipid Syndrome With Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis
Ziakas, P. D., Pavlou, M., & Voulgarelis, M. (2010) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181deba40 · Cited by 185
Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome
Bramham, K., Hunt, B., Germain, S., Calatayud, I., Khamashta, M., Bewley, S., & Nelson-Piercy, C. (2010) · Lupus · doi:10.1177/0961203309347794 · Cited by 185
First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss
Bramham, K., Thomas, M., Nelson-Piercy, C., Khamashta, M., & Hunt, B. J. (2011) · Blood · doi:10.1182/blood-2011-02-339234 · Cited by 180
Antiphospholipid Syndrome
Corban, M., Duarte‐García, A., McBane, R. D., Matteson, E. L., Lerman, L. O., & Lerman, A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.058 · Cited by 186
Recurrent miscarriage: current concepts in diagnosis and treatment
Tóth, B., Jeschke, U., Rogenhofer, N. N., Scholz, C., Würfel, W., Thaler, C., & Makrigiannakis, A. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.12.006 · Cited by 175
Current Concepts and New Trends in the Diagnosis and Management of Recurrent Miscarriage
Alijotas‐Reig, J., & Garrido‐Giménez, C. (2013) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e31828aca19 · Cited by 179
Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia: HABENOX: A randomised multicentre trial
Visser, J., Ulander, V.-M., Helmerhorst, F., Lampinen, K., Morin-Papunen, L., Bloemenkamp, K., & Kaaja, R. (2011) · Thrombosis and Haemostasis · doi:10.1160/th10-05-0334 · Cited by 172
Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications
Rodger, M. A., Carrier, M., Gal, G. L., Martinelli, I., Perna, A., Rey, É., de Vries, J. I. P., & Gris, J. (2013) · Blood · doi:10.1182/blood-2013-01-478958 · Cited by 154
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss
Hamulyák, E. N., Scheres, L. J. J., Marijnen, M. C., Goddijn, M., & Middeldorp, S. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012852.pub2 · Cited by 158
Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications
Cadavid, Á. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00261 · Cited by 134
Mid-Trimester Pregnancy Loss
McNamee, K. M., Dawood, F., & Farquharson, R. G. (2014) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2013.10.007 · Cited by 125
Low Circulating CD4+ CD25+ Foxp3+ T Regulatory Cell Levels Predict Miscarriage Risk in Newly Pregnant Women with a History of Failure
Winger, E. E., & Reed, J. L. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.00992.x · Cited by 121
A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant
Tang, A.-W., Alfirevic, Z., Turner, M. A., Drury, J. A., Small, R., & Quenby, S. M. (2013) · Human Reproduction · doi:10.1093/humrep/det117 · Cited by 117
Antiphospholipid Syndrome during pregnancy: the state of the art.
Prima, F. A. F. D., Valenti, O., Hyseni, E., Giorgio, E., Faraci, M., Renda, E., Domenico, R. D., & Monte, S. (2011) · PubMed Central · Cited by 111
Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity: A European multicentre retrospective study
Salvan, E., Ross, T. D., Gerosa, M., Andreoli, L., Maina, A., Alijotas-Reig, J., Carolis, S. D., Mekinian, A., Bertero, M. T., Canti, V., et al. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-03-0191 · Cited by 108
Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome
Fischer‐Betz, R., & Specker, C. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.09.011 · Cited by 107
Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy
COHN, D. M., GODDIJN, M., MIDDELDORP, S., KOREVAAR, J. C., DAWOOD, F., & FARQUHARSON, R. G. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04015.x · Cited by 99
Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults
Tektonidou, M. G., Andréoli, L., Limper, M., Tincani, A., & Ward, M. M. (2019) · RMD Open · doi:10.1136/rmdopen-2019-000924 · Cited by 101
Diagnosis and management of non-criteria obstetric antiphospholipid syndrome
Machin, S. J., Mackie, I. J., Cohen, H., & Arachchillage, D. J. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-05-0416 · Cited by 97
Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis
Roberge, S., Demers, S., Nicolaides, K. H., Bureau, M., Côté, S., & Bujold, E. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15789 · Cited by 95
A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia
Skeith, L., Carrier, M., Kaaja, R., Martinelli, I., Petroff, D., Schleußner, E., Laskin, C. A., & Rodger, M. A. (2016) · Blood · doi:10.1182/blood-2015-12-626739 · Cited by 96
Self-citation
Managing antiphospholipid syndrome in pregnancy
Schreiber, K. I., & Hunt, B. J. (2019) · Thrombosis Research · doi:10.1016/s0049-3848(19)30366-4 · Cited by 96
Is thrombophilia associated with placenta‐mediated pregnancy complications? A prospective cohort study
Rodger, M. A., WALKER, M. C., Smith, G. N., Wells, P. S., Ramsay, T., Langlois, N. J., Carson, N. L., Carrier, M., White, R. R., Shachkina, S., et al. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12509 · Cited by 94
Characteristics of Patients With Antiphospholipid Antibody Positivity in the APS ACTION International Clinical Database and Repository
Sevim, E., Zisa, D., Andrade, D., Sciascia, S., Pengo, V., Tektonidou, M. G., Ugarte, A., Gerosa, M., Belmont, H. M., Zamorano, M. A. A., et al. (2022) · Arthritis Care & Research · doi:10.1002/acr.24468 · Cited by 88
Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire
Diejomaoh, M. (2014) · Medical Principles and Practice · doi:10.1159/000365973 · Cited by 91
Effect of Hydroxychloroquine on Antiphospholipid Antibody‐Induced Changes in First Trimester Trophoblast Function
Albert, C. R., Schlesinger, W. J., Viall, C. A., Mulla, M. J., Brosens, J. J., Chamley, L., & Abrahams, V. M. (2013) · American Journal of Reproductive Immunology · doi:10.1111/aji.12184 · Cited by 87
Modulation of Trophoblast Angiogenic Factor Secretion by Antiphospholipid Antibodies is Not Reversed by Heparin
Carroll, T. Y., Mulla, M. J., Han, C. S., Brosens, J. J., Chamley, L., Giles, I., Pericleous, C., Rahman, A., Sfakianaki, A. K., Paidas, M. J., et al. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.01007.x · Cited by 85
How I treat the antiphospholipid syndrome
Giannakopoulos, B., & Krilis, S. A. (2009) · Blood · doi:10.1182/blood-2009-05-220756 · Cited by 83
Low-molecular-weight heparin and aspirin in the prevention of recurrent early-onset pre-eclampsia in women with antiphospholipid antibodies: the FRUIT-RCT
van Hoorn, M. E., Hague, W. M., van Pampus, M. G., Bezemer, D., & de Vries, J. I. P. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2015.12.011 · Cited by 84
Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period
Middleton, P., Shepherd, E. S., & Gomersall, J. S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001689.pub4 · Cited by 84
High-risk pregnancy and the rheumatologist
Soh, M. C., & Nelson‐Piercy, C. (2014) · Rheumatology · doi:10.1093/rheumatology/keu394 · Cited by 84
Pregnancy loss and thrombophilia: the elusive link
Bennett, S. A., Bagot, C. N., & Arya, R. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09112.x · Cited by 75
Multiple Pregnancy Failures: An Immunological Paradigm
Matthiesen, L., Kalkunte, S. S., & Sharma, S. (2012) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2012.01121.x · Cited by 74
Antiphospohlipid syndrome in obstetrics
Danza, Ã., Ruiz‐Irastorza, G., & Khamashta, M. A. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.10.006 · Cited by 74
Review: Low-molecular-weight heparin-induced osteoporosis and osteoporotic fractures: A myth or an existing entity?
Lefkou, E. E., Khamashta, M. A., Hampson, G., & Hunt, B. J. (2009) · Lupus · doi:10.1177/0961203309353171 · Cited by 72
Analysis of Plasminogen Activator Inhibitor‐1, Integrin Beta3, Beta Fibrinogen, and Methylenetetrahydrofolate Reductase Polymorphisms in Iranian Women with Recurrent Pregnancy Loss
Jeddi‐Tehrani, M., Torabi, R., Zarnani, A., Mohammadzadeh, A., Arefi, S., Zeraati, H., Akhondi, M. M., Chamani‐Tabriz, L., Idali, F., Emami, S., et al. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00974.x · Cited by 70
Thrombophilia and early pregnancy loss
McNamee, K. M., Dawood, F., & Farquharson, R. G. (2011) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.10.002 · Cited by 67
Does low-dose aspirin initiated before 11 weeks’ gestation reduce the rate of preeclampsia?
Chaemsaithong, P., Cuenca-Gómez, D., Plana, N., Gil, M. M., & Poon, L. C. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.08.047 · Cited by 73
Hydroxychloroquine may be beneficial in preeclampsia and recurrent miscarriage
MOREUIL, C. D., Alavi, Z., & Pasquier, É. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14131 · Cited by 67
The treatment of anti-phospholipid syndrome: A comprehensive clinical approach
Chighizola, C. B., Andréoli, L., Gerosa, M., Tincani, A., Ruffatti, A., & Meroni, P. L. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.02.003 · Cited by 66
Antiphospholipid syndrome management: a 2023 update and practical algorithm-based approach
Ambati, A., Knight, J. S., & Zuo, Y. (2023) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000932 · Cited by 68
Antithrombotic therapy for pregnancy loss
de Jong, P. G., Goddijn, M., & Middeldorp, S. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt019 · Cited by 63
Aspirin‐Triggered Lipoxin Prevents Antiphospholipid Antibody Effects on Human Trophoblast Migration and Endothelial Cell Interactions
Álvarez, Á. M., Mulla, M. J., Chamley, L., Cadavid, Á. P., & Abrahams, V. M. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38934 · Cited by 62
Managing pregnancy in inflammatory rheumatological diseases
Jain, V., & Gordon, C. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3227 · Cited by 62
ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia - study protocol for a randomized controlled trial
de Jong, P. G., Quenby, S. M., Bloemenkamp, K. W. M., Braams‐Lisman, B. A. M., de Bruin, J. P., Coomarasamy, A., David, M., DeSancho, M. T., van der Heijden, O. W. H., Hoek, A., et al. (2015) · Trials · doi:10.1186/s13063-015-0719-9 · Cited by 60
Is heparin a placental anticoagulant in high-risk pregnancies?
Kingdom, J. C., & Drewlo, S. (2011) · Blood · doi:10.1182/blood-2011-07-319749 · Cited by 58
Self-citation
Care prior to and during subsequent pregnancies following stillbirth for improving outcomes
Wojcieszek, A. M., Shepherd, E., Middleton, P., Lassi, Z. S., Wilson, T., Murphy, M. M., Heazell, A. E., Ellwood, D. A., Silver, R. M., & Flenady, V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012203.pub2 · Cited by 55
LMWH to prevent placenta‐mediated pregnancy complications: an update
Duffett, L. D., & Rodger, M. A. (2014) · British Journal of Haematology · doi:10.1111/bjh.13209 · Cited by 55
Antithrombotic treatment for pregnancy complications: which path for the journey to precision medicine?
Greer, I. A., Brenner, B., & Gris, J. (2014) · British Journal of Haematology · doi:10.1111/bjh.12813 · Cited by 54
Current insights in obstetric antiphospholipid syndrome
Schreiber, K. I., Radin, M., & Sciascia, S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000406 · Cited by 53
Report of the Obstetric APS Task Force: 13th International Congress on Antiphospholipid Antibodies, 13th April 2010
Branch, W. D. (2011) · Lupus · doi:10.1177/0961203310395054 · Cited by 53
Placental Infarction and Thrombophilia
Franco, C. D., Walker, M. G., Robertson, J. E., Fitzgerald, B., Keating, S. J., McLeod, A. G., & Kingdom, J. C. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31820ca040 · Cited by 50
Self-citation
Everything the clinician needs to know about evidence-based anticoagulation in pregnancy
Scheres, L. J. J., Bistervels, I. M., & Middeldorp, S. (2018) · Blood Reviews · doi:10.1016/j.blre.2018.08.001 · Cited by 51
Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling
Drewlo, S., Levytska, K., Sobel, M. L., Baczyk, D., Lye, S. J., & Kingdom, J. C. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04526.x · Cited by 49
Self-citation
Pregnancy Morbidity in Antiphospholipid Syndrome: What Is the Impact of Treatment?
de Jesús, G. R., Rodrigues, G., de Jesús, N. R., & Levy, R. A. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-013-0403-6 · Cited by 47
Bemiparin versus low dose aspirin for management of recurrent early pregnancy losses due to antiphospholipd antibody syndrome
Alalaf, S. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2055-y · Cited by 47
Factors associated with adverse pregnancy outcomes in women with antiphospholipid syndrome: A multicenter study
Deguchi, M., Yamada, H., Sugiura‐Ogasawara, M., Morikawa, M., Fujita, D., Miki, A., Makino, S., & Murashima, A. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.08.001 · Cited by 47
Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies
Girardi, G. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.09.009 · Cited by 46
Testing for Inherited Thrombophilia in Recurrent Miscarriage
de Jong, P. G., Goddijn, M., & Middeldorp, S. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1293207 · Cited by 47
Rheumatic diseases and pregnancy
Märker‐Hermann, E., & Fischer‐Betz, R. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283404d67 · Cited by 44
Aspirin or heparin or both in the treatment of recurrent spontaneous abortion in women with antiphospholipid antibody syndrome: a meta-analysis of randomized controlled trials
Lu, C. F., Liu, Y., & Jiang, H. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1404979 · Cited by 44
Heparin for pregnant women with acquired or inherited thrombophilias
WALKER, M. C., Ferguson, S. E., & Allen, V. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003580 · Cited by 44
Antiphospholipid syndrome: an update
Merashli, M., Noureldine, M. H. A., Uthman, I. W., & Khamashta, M. A. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12449 · Cited by 44
Inherited Thrombophilia and Pregnancy Complications: Should We Test?
Makris, M., & Arachchillage, D. J. (2018) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1657782 · Cited by 42
An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus
Teng, Y. K. O., Bredewold, O. W., Rabelink, T. J., Huizinga, T. W. J., Eikenboom, J. C. J., Limper, M., Fritsch-Stork, R. D. E., Bloemenkamp, K. W. M., & Sueters, M. (2017) · Rheumatology · doi:10.1093/rheumatology/kex374 · Cited by 42
Recent thoughts on management and prevention of recurrent early pregnancy loss
Tang, A.-W., & Quenby, S. M. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32833e124e · Cited by 43
Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll‐like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling
Tong, M., Kayani, T., Jones, D. M., Salmon, J. E., Whirledge, S., Chamley, L., & Abrahams, V. M. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42068 · Cited by 40
Evaluation of Recurrent Pregnancy Loss
de Assis, V., Schenone, C. V., & Ros, S. T. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005498 · Cited by 46
Preventing venous thromboembolism during pregnancy and postpartum: crossing the threshold
Skeith, L. (2017) · Hematology · doi:10.1182/asheducation-2017.1.160 · Cited by 40
Antithrombotic therapy to prevent recurrent pregnancy loss in antiphospholipid syndrome—What is the evidence?
Hamulyák, E. N., Scheres, L. J. J., Goddijn, M., & Middeldorp, S. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15290 · Cited by 39
Obstetric antiphospholipid syndrome: current uncertainties should guide our way
Branch, D., Silver, R. M., & Porter, T. (2010) · Lupus · doi:10.1177/0961203310361490 · Cited by 36
Use of D‐dimer measurement to guide anticoagulant treatment in recurrent pregnancy loss associated with antiphospholipid syndrome
Bao, S., Sheng, S. L., Liao, H., Zhou, Q., Frempong, S. T., & Tu, W. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12770 · Cited by 38
Anticardiolipin antibodies and recurrent early pregnancy loss: a century of equivocal evidence
Clark, C. A., Laskin, C. A., & Spitzer, K. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms020 · Cited by 37
Self-citation
Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome
Turğal, M., Gümrük, F., Karaağaoğlu, E., & Beksaç, M. S. (2018) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-0664-8237 · Cited by 37
Unfractionated heparin for second trimester placental insufficiency: a pilot randomized trial
Kingdom, J. C., WALKER, M., Proctor, L., Keating, S. J., Shah, P. S., McLeod, A. G., Keunen, J., Windrim, R. C., & Dodd, J. M. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04407.x · Cited by 37
Self-citation
Maternal Malaria Induces a Procoagulant and Antifibrinolytic State That Is Embryotoxic but Responsive to Anticoagulant Therapy
Avery, J. W., Smith, G., Owino, S. O., Sarr, D., Nagy, T., Mwalimu, S., Matthias, J., Kelly, L. F., Poovassery, J. S., Middii, J. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031090 · Cited by 37
The basis and value of currently used immunomodulatory therapies in recurrent miscarriage
Bansal, A. S., Bajardeen, B., & Thum, M. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.10.002 · Cited by 37
Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage
van den Boogaard, E., Cohn, D. M., Korevaar, J. C., Dawood, F., Vissenberg, R., Middeldorp, S., Goddijn, M., & Farquharson, R. G. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.002 · Cited by 36
Low-molecular-weight heparin for prevention of placenta-mediated pregnancy complications: protocol for a systematic review and individual patient data meta-analysis (AFFIRM)
Rodger, M. A., Langlois, N. J., de Vries, J. I. P., Rey, É., Gris, J., Martinelli, I., Schleußner, E., Ramsay, T., Mallick, R., Skidmore, B., et al. (2014) · Systematic Reviews · doi:10.1186/2046-4053-3-69 · Cited by 36
Effects and effectiveness of heparin in assisted reproduction
Bohlmann, M. K. (2011) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2011.03.004 · Cited by 36
Antiphospholipid syndrome: a clinical perspective
Zuo, Y., Shi, H., Li, C., & Knight, J. S. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000705 · Cited by 39

Authors: LASKIN, C. A., SPITZER, K. A., CLARK, C. A., CROWTHER, M. R., GINSBERG, J. S., HAWKER, G. A., KINGDOM, J. C., BARRETT, J., & GENT, M.
Affiliations: University of Toronto (CA)
Mount Sinai Hospital (CA)
ORCID: LASKIN, CARL A.
HAWKER, GILLIAN A.
KINGDOM, JOHN C.
Venue: The Journal of Rheumatology
Publisher: The Journal of Rheumatology
Published: 2009-02
Volume: 36
Issue: 2
Pages: 279-287
ISSN: 0315-162X (ISSN-L)
1499-2752
DOI: 10.3899/jrheum.080763
OpenAlex: W2022226231
Cited by: 352
References: 43
Citations by year: 2026: 8 · 2025: 5 · 2024: 10 · 2023: 12 · 2022: 13 · 2021: 11 · 2020: 18 · 2019: 19 · 2018: 16 · 2017: 33 · 2016: 11 · 2015: 28 · 2014: 33 · 2013: 22 · 2012: 19
FWCI: 15.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Rheumatology (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Pfizer Canada
Canadian Institutes of Health Research
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: recurrent pregnancy loss, low molecular weight heparin, aspirin, antiphospholipid antibodies, antithrombotic therapy, live birth rate, bone mineral density, inherited thrombophilia, antinuclear antibodies, pregnancy loss prevention, adverse events, bone loss
MeSH terms: Abortion, Habitual, Adult, Anticoagulants, Antibodies, Antinuclear, Aspirin, Autoimmune Diseases, Blood Coagulation Disorders, Female, Heparin, Low-Molecular-Weight, Humans, Platelet Aggregation Inhibitors, Pregnancy, Pregnancy Complications, Hematologic, Cohort Studies, Bone Density, Antiphospholipid Syndrome, Treatment Outcome, Thrombophilia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Low Molecular Weight Heparin and Aspirin for Recurrent Pregnancy Loss: Results from the Randomized, Controlled HepASA Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks