Cited by 185Systemic Lupus Erythematosus ResearchReproductive System and PregnancyPregnancy and preeclampsia studies

Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome

Bramham, K., Hunt, BJ, Germain, S., Calatayud, I., Khamashta, M., Bewley, S., Nelson-Piercy, C.·2010·Lupus

Abstract

Women with antiphospholipid syndrome (APS) may have diverse pregnancy outcomes. The objective of this study was to evaluate pregnancy outcome in women with APS according to their clinical phenotype, i.e. thrombotic and obstetric APS. Eighty-three pregnancies in 67 women with APS were included in the study, including 21 with recurrent miscarriage (Group 1), 21 with late fetal loss or early delivery due to placental dysfunction (Group 2) and 41 with thrombotic APS (Group 3). Group 3 had higher rates of preterm delivery (26.8% versus 4.7%, p = 0.05) than Group 1 and more small for gestational age (SGA) babies than Group 2 (39.5% versus 4.8%, p = 0.003). Group 2 had significantly longer gestations compared with their pretreatment pregnancies (38.4 [28.4-41.4] versus 24.0 [18-35] weeks, p < 0.0001) and 100% live birth rate after treatment with aspirin and low-molecular-weight heparin (LMWH). In conclusion, women with thrombotic APS (Group 3) have higher rates of pregnancy complications than those with obstetric APS (Groups 1 and 2). Treatment with aspirin and LMWH is associated with improved outcomes for women with previous late fetal loss or early delivery due to placental dysfunction (Group 2).

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Crossref · 10.1177/0961203309347794

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  • In observational studies, LDA plus therapeutic dose heparin was associated with live births in 79% of pregnancies on average.

    “In observational studies, treatment with LDA and therapeutic dose heparin was associated with live births in 79% of pregnancies on average.52 61–64”

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Authors
Bramham, K., Hunt, B., Germain, S., Calatayud, I., Khamashta, M., Bewley, S., & Nelson-Piercy, C.
Affiliations
  • Guy's Hospital (GB)
  • Department of Maternal Medicine, Women's services directorate and Lupus Unit, Guy's & St Thomas' NHS Foundation Trust, London, UK
  • Department of Maternal Medicine, Women's services directorate and Lupus Unit, Guy's & St Thomas' NHS Foundation Trust, London, UK,
Venue
Lupus
Published
2009-11-06
Volume
19
Issue
1
Pages
58-64
ISSN
  • 0961-2033 (ISSN-L)
  • 1477-0962
OpenAlex
W2043383287
Cited by
185
References
40
Citations by year
2026: 5 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 15 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 15
FWCI
9.64
Type
journal article
Language
en
Open access
closed
Locations
  • Lupus (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
National Institute for Health and Care Research (DRF-2009-02-18)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
antiphospholipid syndrome, pregnancy outcomes, clinical phenotype, thrombotic antiphospholipid syndrome, obstetric antiphospholipid syndrome, recurrent pregnancy loss, placental insufficiency, preterm birth, small for gestational age, aspirin, low molecular weight heparin
MeSH terms
Adult, Aspirin, Female, Heparin, Low-Molecular-Weight, Humans, Infant, Newborn, Infant, Small for Gestational Age, Obstetric Labor, Premature, Phenotype, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Retrospective Studies, Antiphospholipid Syndrome

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