Use of Highly Sensitive C-Reactive Protein for Followup of Wegener’s Granulomatosis
Open accessAbstract
Objective.: Since Wegener’s granulomatosis (WG) represents a relapsing disease, efforts have been made to reliably predict relapses using blood tests. Followup measures such as conventionally determined C-reactive protein (CRP), antineutrophil cytoplasmic antibody (C-ANCA) titer, and proteinase-3 (PR3) ELISA are applied. We evaluated whether during remission elevated highly sensitive CRP (hsCRP) precedes relapse as a marker of subclinical inflammation and thus might improve clinical assessment. Methods.: We investigated 227 sera of 57 patients with WG: 74 sera collected from patients in remission who subsequently relapsed (before relapse), 30 sera collected during relapse, and 123 sera from patients in remission without relapse. We also distinguished between major and minor relapse. hsCRP, conventionally determined CRP (CRP), C-ANCA, PR3-ELISA, and erythrocyte sedimentation rate (ESR) were measured using commercial kits, and levels were correlated to clinical status. Results.: Only hsCRP and ANCA titer, but not CRP levels, were higher in sera from patients who subsequently relapsed versus those who did not, indicating patients at risk. Levels of hsCRP, CRP, and ESR were higher in sera collected during relapse than in the sera before relapse. hsCRP, conventional CRP, and ESR were also higher in samples collected during major relapse than before major relapse. Looking at the levels just before relapse compared to previous levels during remission, none of these measures rose directly before the clinical manifestation of the relapse. Conclusion.: Our study provides evidence for an additional value of hsCRP in the clinical assessment of patients with WG.
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Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
van der Woude, F. J., Lobatto, S., Permin, H., van der Giessen, M., Rasmussen, N., Wiik, A. S., van Es, L. A., van der Hem, G. K., & THE, T. H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91147-x · Cited by 1,879 · see citing works
Novel Risk Factors for Systemic Atherosclerosis
Ridker, P. M., Stampfer, M. J., & Rifai, N. (2001) · JAMA · doi:10.1001/jama.285.19.2481 · Cited by 1,300 · see citing works
Macy, E. M., Hayes, T. E., & Tracy, R. P. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.1.52 · Cited by 797 · see citing works
Tracy, R. P., Psaty, B. M., Macy, E., Bovill, E. G., Cushman, M., Cornell, E. S., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.10.2167 · Cited by 539 · see citing works
Regulation of complement activation by C-reactive protein
Mold, C., Gewurz, H., & Du Clos, T. W. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00007-7 · Cited by 326 · see citing works
Kerr, G. S., Fleisher, T. A., Hallahan, C. W., Leavitt, R. Y., Fauci, A. S., & Hoffman, G. S. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360312 · Cited by 293 · see citing works
Finkielman, J. D., Merkel, P. A., Schroeder, D. R., Hoffman, G. S., Spiera, R., Clair, E. W. S., Davis, J. C., McCune, W. J., Lears, A., Ytterberg, S. R., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-9-200711060-00005 · Cited by 264 · see citing works
ANCA and predicting relapse in systemic vasculitis
Jayne, D. R. W., Gaskin, G., Pusey, C. D., & Lockwood, C. M. (1995) · QJM · doi:10.1093/oxfordjournals.qjmed.a069033 · Cited by 202 · see citing works
Cantini, F., Salvarani, C., Olivieri, I., Macchioni, L., Ranzi, A., Niccoli, L., Padula, A. A., & Boiardi, L. (2000) · Seminars in Arthritis and Rheumatism · doi:10.1053/sarh.2000.8366 · Cited by 186 · see citing works
Birck, R., Schmitt, W. H., Kaelsch, I. A., & van der Woude, F. J. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.09.022 · Cited by 128 · see citing works
Self-citationde Maat, M. P. M., de Bart, A. C. W., Hennis, B. C., Meijer, P., Havelaar, A. C., Mulder, P. G. H., & Kluft, C. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.9.1156 · Cited by 124 · see citing works
C‐Reactive Protein in Systemic Lupus Erythematosus
Honig, S., Gorevic, P. D., & Weissmann, G. (1977) · Arthritis & Rheumatism · doi:10.1002/art.1780200505 · Cited by 99 · see citing works
Woollard, K. J., PHILLIPS, D. C., & Griffiths, H. R. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01978.x · Cited by 98 · see citing works
High Sensitivity C-reactive Protein: An Emerging Role in Cardiovascular Risk Assessment
Benzaquen, L. R., Yu, H., & Rifai, N. (2002) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360290795556 · Cited by 69 · see citing works
C‐reactive protein as a regulator of autoimmunity and inflammation
Clos, T. W. D. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11025 · Cited by 68 · see citing works
Nowack, R., Grab, I., Flores‐Suarèz, L., Schnülle, P., Yard, B. A., & van der Woude, F. J. (2001) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/16.8.1631 · Cited by 67 · see citing works
Self-citationKoelewijn, C. L., Schwartz, M. P., Samsom, M., & Oldenburg, B. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.85 · Cited by 52 · see citing works
Hind, C. R. K., Winearls, C. G., Lockwood, C. M., Rees, A. J., & Pepys, M. B. (1984) · PubMed · Cited by 50 · see citing works
Merkel, P. A., Seo, P., Aries, P., Neogi, T., Villa‐Forte, A., Boers, M., Cuthbertson, D. D., Felson, D. T., Hellmich, B., Hoffman, G. S., et al. (2005) · PubMed · Cited by 41 · see citing works
Tervaert, J. W. C., Stegeman, C. A., & Kallenberg, C. (1996) · PubMed · Cited by 34 · see citing works
Atherosclerosis in ANCA‐Associated Vasculitides
Pagnoux, C., Chironi, G. N., Simon, A. C., & Guillevin, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.002 · Cited by 28 · see citing works
Biological markers in inflammatory rheumatic diseases.
Hilliquin, P. (1995) · PubMed · Cited by 27 · see citing works
Abdou, A. S., Magour, G. M., & Mahmoud, M. M. (2009) · British Journal of Biomedical Science · doi:10.1080/09674845.2009.11730261 · Cited by 20 · see citing works
Alpha-1-Antitrypsin, CRP and Interleukin-6 in ANCA-positive Vasculitis
Grönhagen‐Riska, C., Teppo, A., Honkanen, E. O., & Ikäheimo, R. (1993) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-9182-2_55 · Cited by 5 · see citing works
Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9
Flagged first, then by citations
1 of the 27 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Boomsma MM, Stegeman CA, van der Leij MJ, Oost W, Hermans J, Kallenberg CG, et al. Prediction of relapses in Wegener;s granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. Arthritis Rheum 2000;43:2025-33.
Cited by
Sorted by citations
Diagnosis and management of ANCA-associated vasculitis
Kronbichler, A., Bajema, I. M., Bruchfeld, A. N., Kirsztajn, G. M., & Stone, J. H. (2024) · The Lancet · doi:10.1016/s0140-6736(23)01736-1 · Cited by 203 · see citing works
Mouliou, D. S. (2023) · Diseases · doi:10.3390/diseases11040132 · Cited by 185 · see citing works
Monach, P. A., Warner, R. L., Tómasson, G., Specks, U., Stone, J. H., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. S., Iklé, D. N., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201981 · Cited by 139 · see citing works
Decreased CD5+ B Cells in Active ANCA Vasculitis and Relapse after Rituximab
Bunch, D. O., McGregor, J. G., Khandoobhai, N. B., Aybar, L. T., Burkart, M., Hu, Y., Hogan, S. L., Poulton, C. J., Berg, E. A., Falk, R. J., et al. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03950412 · Cited by 100 · see citing works
Monach, P. A. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000009 · Cited by 76 · see citing works
Monach, P. A., Tómasson, G., Specks, U., Stone, J. H., Cuthbertson, D. D., Krischer, J. P., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. S., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30615 · Cited by 66 · see citing works
Kronbichler, A., Kerschbaum, J., Gründlinger, G., Leierer, J., Mayer, G. J., & Rudnicki, M. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv336 · Cited by 63 · see citing works
Pelkmans, L. G., Aarnoudse, A. L. H. J., Hendriksz, T. R., & van Bommel, E. F. H. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr779 · Cited by 43 · see citing works
Xu, P., Lin, S., Yang, X., Gu, D.-M., Yan, T.-K., Wei, L., & Wang, B. (2015) · BMC Immunology · doi:10.1186/s12865-015-0077-0 · Cited by 37 · see citing works
Relation between Asymptomatic Proteinase 3 Antibodies and Future Granulomatosis with Polyangiitis
Olson, S. W., Owshalimpur, D., Yuan, C. M., Arbogast, C. B., Baker, T. P., Oliver, D. K., & Abbott, K. C. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10411012 · Cited by 32 · see citing works
Vodolazkaia, A., Bossuyt, X., Fassbender, A., Kyama, C. M., Meuleman, C., Peeraer, K., Tomassetti, C., & D'Hooghe, T. M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-113 · Cited by 28 · see citing works
“In the mentioned studies, hsCRP levels were more closely associated with disease activity than CRP levels [29,31].”
BackgroundResultChen, S., Wang, F., Li, Z., Yu, F., Chen, M., & Zhao, M. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.11.013 · Cited by 25 · see citing works
Disease assessment in systemic vasculitis
Luqmani, R. A. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv002 · Cited by 19 · see citing works
Wu, K., Liang, Q., Huang, B.-T., Ding, N., Li, B., & Hao, J. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02321-w · Cited by 17 · see citing works
Circulating Angiopoietin-2 as a Biomarker in ANCA-Associated Vasculitis
Monach, P. A., Kümpers, P., Lukasz, A. H., Tómasson, G., Specks, U., Stone, J. H., Cuthbertson, D. D., Krischer, J. P., Carette, S., Ding, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030197 · Cited by 17 · see citing works
Biomarkers in ANCA-Associated Vasculitis
Lally, L., & Spiera, R. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0363-x · Cited by 16 · see citing works
The pentraxin family in autoimmune disease
Li, Y., Zhang, S., Liu, J., Zhang, N., Zhang, N., Cheng, Q., Zhang, H., & Wu, X. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117592 · Cited by 15 · see citing works
Watanabe, H., Sada, K., Harigai, M., Amano, K., Dobashi, H., Takasaki, Y., Fujimoto, S., Atsumi, T., Yamagata, K., Homma, S. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84627-6 · Cited by 15 · see citing works
Monach, P. A., Warner, R. L., Lew, R., Tómasson, G., Specks, U., Stone, J. H., Fervenza, F. C., Hoffman, G. S., Kallenberg, C. G. M., Langford, C. A., et al. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11366 · Cited by 15 · see citing works
Myeloperoxidase influences the complement regulatory function of modified C-reactive protein
Xu, P., Li, Z., Yang, X.-W., Zhao, M., & Chen, M. (2013) · Innate Immunity · doi:10.1177/1753425913508164 · Cited by 15 · see citing works
Kling, L., Benck, U., Breedijk, A. J., Leikeim, L., Heitzmann, M., Porubský, Š., Krämer, B. K., Yard, B. A., & Kälsch, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12011-4 · Cited by 15 · see citing works
Self-citationInvestigations in systemic vasculitis. The role of the laboratory
Csernok, E., & Bossuyt, X. (2018) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2018.07.005 · Cited by 14 · see citing works
Self-citationA Case Series of Granulomatosis With Polyangiitis Primarily Diagnosed by Otological Manifestations
Sahyouni, R., Moshtaghi, O., Abouzari, M., Le, P., Birkenbeuel, J. L., Cheung, D., Lin, H. W., & Djalilian, H. R. (2018) · Annals of Otology Rhinology & Laryngology · doi:10.1177/0003489418815517 · Cited by 14 · see citing works
Diagnostik und Therapie der ANCA-assoziierten Vaskulitiden
Holle, J. U., Kubacki, T., Aries, P., Hellmich, B., Kernder, A. L., Kneitz, C., Lamprecht, P., Schirmer, J. H., Schreiber, A., Berlit, P., et al. (2025) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-024-01597-6 · Cited by 13 · see citing works
Mosakowska, M., Kania, D. B., Szamotulska, K., Rymarz, A., & Niemczyk, S. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02495-8 · Cited by 13 · see citing works
Biomarkers Predict Relapse in Granulomatosis with Polyangiitis
Hogan, P. C. P., O'Connell, R. M., Scollard, S., Browne, E., Hackett, E. E., & Feighery, C. (2014) · Journal of Biomarkers · doi:10.1155/2014/596503 · Cited by 12 · see citing works
Romand, X., Paclet, M. H., Nguyen, M. V. C., Gaudin, P., Pagnoux, C., Guillevin, L., Terrier, B., & Baillet, A. C. (2023) · RMD Open · doi:10.1136/rmdopen-2023-003477 · Cited by 11 · see citing works
Jeong, Y., Lee, B. J., Hur, W., Lee, M. J., & Han, S. (2024) · Metabolites · doi:10.3390/metabo14070371 · Cited by 8 · see citing works
New Insights on Biomarkers in Systemic Vasculitis
Pérez-Alamino, R., & Maldonado-Ficco, H. (2015) · Current Rheumatology Reports · doi:10.1007/s11926-015-0497-0 · Cited by 8 · see citing works
Utilidad de los anticuerpos anticitoplasma de neutrófilo en reumatología
Flores-Suárez, L. F. (2012) · Reumatología Clínica · doi:10.1016/j.reuma.2012.03.002 · Cited by 6 · see citing works
Valenzuela, L. M., Draibe, J. B., Quero, M., Fulladosa, X., Cruzado, J. M., Bestard, O., & Torrás, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235820 · Cited by 6 · see citing works
Xu, P., Hao, J., Yang, X.-W., Chang, D., Chen, M., & Zhao, M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.05.012 · Cited by 5 · see citing works
How We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy
Roccatello, D., Fenoglio, R., Simone, E. D., & Sciascia, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14010208 · Cited by 4 · see citing works
Antineutrophil Cytoplasm Autoantibodies: Usefulness in Rheumatology
Flores-Suárez, L. F. (2012) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2012.07.002 · Cited by 3 · see citing works
Serological testing in small vessel vasculitis
Segelmark, M. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez633 · Cited by 3 · see citing works
Towards a proteomic plasma biomarker panel for diagnosing vasculitis remission
Jerke, U., Kirchner, M., Bartolomaeus, T. U., Kling, L., Krátký, V., Hrušková, Z., Tesař, V., Eckardt, K., Schreiber, A., Forslund, S. K., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75755-6 · Cited by 2 · see citing works
Gancarczyk, U., Podolec, P. S., Przewłocki, T., Prochownik, P., & Komar, M. (2019) · Wiadomości Lekarskie · doi:10.36740/wlek201910137 · Cited by 1 · see citing works
Valenzuela, L. M., Pàmpols, P. A., Preciado, F. G., Fernandez-Juarez, G., Oliveras, X. F., Cruzado, J. M., Ambrós, J. T., & Draibe, J. B. (2025) · Nefrología · doi:10.1016/j.nefro.2025.501472 · Cited by 1 · see citing works
Monach, P. A., Warner, R. L., Tómasson, G., Specks, U., Stone, J. H., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. S., Iklé, D. N., et al. (2011) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1 · see citing works
Luqmani, R. A. (2019) · Rare diseases of the immune system · doi:10.1007/978-3-030-02239-6_5 · Cited by 1 · see citing works
Yamaguchi, M., Ito, M., Sugiyama, H., Iwagaitsu, S., Nobata, H., Kinashi, H., Katsuno, T., Ando, M., Kubo, Y., Banno, S., et al. (2022) · Modern Rheumatology · doi:10.1093/mr/roac146 · Cited by 1 · see citing works
Mosakowska, M., Brodowska-Kania, D. A., Szamotulska, K., Rymarz, A., & Niemczyk, S. (2021) · Research Square · doi:10.21203/rs.3.rs-308105/v1
Métricas nas vasculites sistêmicas
de Aguiar, M. F., Dantas, J. G. T., Bacchiega, A. B. S., & Sachetto, Z. (2022) · Revista Paulista de Reumatologia · doi:10.46833/reumatologiasp.2022.21.2.59-71
Valenzuela, L. M., Antón-Pàmpols, P., Preciado, F. G., Juarez, G. M. F., Fulladosa, X., Cruzado, J. M., Ambrós, J. T., & Draibe, J. B. (2026) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2026.501472
- Authors
- KÄLSCH, A.-I., CSERNOK, E., MÜNCH, D., BIRCK, R., YARD, B. A., GROSS, W., KÄLSCH, T., & SCHMITT, W. H.
- Affiliations
- Heidelberg University (DE)
- University Medical Centre Mannheim (DE)
- Venue
- The Journal of Rheumatology
- Publisher
- The Journal of Rheumatology
- Published
- 2010-08-17
- Volume
- 37
- Issue
- 11
- Pages
- 2319-2325
- ISSN
- 0315-162X (ISSN-L)
- 1499-2752
- OpenAlex
- W2057100519
- Cited by
- 44
- References
- 27
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 6
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Keywords
- granulomatosis with polyangiitis, high-sensitivity C-reactive protein, recurrence prediction, subclinical inflammation, ANCA titers, proteinase 3, erythrocyte sedimentation rate, disease activity monitoring, remission
- MeSH terms
- C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Recurrence, Granulomatosis with Polyangiitis, Biomarkers, Antibodies, Antineutrophil Cytoplasmic
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