Thyrotropin binding inhibiting antibody (TBIAb) in Graves' disease
Open accessAbstract
To determine the nature of TBIAb in Graves’ disease, TBIAb was measured and correlated to various clinical, thyroid functional indices and thyroid autoantibodies. The incidence of TBIAb in untreated Graves’ patients, patients in treatment and those in remission was 70.9%, 53.1% and 19.2%, respectively. With respect to clinical indices, there was no correlation between TBIAb and the presence of exophthalmos or periodic paralysis, onset age, diseage duration or sex, but goiter size on initial examination did show significant correlation (r=0.95). Regarding the indices of thyroid function, 20min 99m-Tc uptake (r=0.28), free T4 index (r=0.39) and free T3 index (r=0.40) were well correlated to TBIAb activity. Also Grave’s patients with strong antimicrosomal activity exhibited a high incidence of TBIAb positiveness.
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TSH receptor binding inhibitory immunoglobulin assay (TBIAb) has an incidence of 70.9% in untreated Graves' disease, 53.1% in currently treated Graves' disease, and 19.2% in remission from Graves' disease.
“However, we were able to obtain a TSH receptor binding inhibitory immunoglobulin assay (TBIAb) which has an incidence of 70.9% (untreated Graves’ disease), 53.1% (currently being treated for Graves’ disease), and 19.2% (in remission from Graves’ disease) [8].”
From Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study (2023) · cites this paper as [8]
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Cites
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Research works printed but not linked: 1
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Thyrotoxic Periodic Paralysis With Hypokalemia: A Case Study
Mebane, N. B., Khan, A., Bevinal, M., & Davis, E. (2023) · Cureus · doi:10.7759/cureus.40757 · Cited by 3 · see citing works
“2% (in remission from Graves’ disease) [8].”
- Authors
- Cho, W. Y., Choi, H. H., Chun, H. J., & Ahn, I. M.
- Affiliations
- Korea University (KR)
- Corresponding author
- Ahn, Il Min
- ORCID
- Cho, Won Yong
- Venue
- The Korean Journal of Internal Medicine
- Published
- 1988-01-31
- Volume
- 3
- Issue
- 1
- Pages
- 45-52
- ISSN
- 1226-3303 (ISSN-L)
- 2005-6648
- PMC
- PMC4532134
- OpenAlex
- W1132164187
- Cited by
- 1
- References
- 18
- Citations by year
- 2023: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- The Korean Journal of Internal Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Keywords
- Graves' disease, thyroid autoantibodies, thyroid function, thyroid autoimmunity
- MeSH terms
- Adolescent, Adult, Aged, Autoantibodies, Child, Female, Graves Disease, Humans, Male, Middle Aged, Thyroid Gland, Thyroiditis, Autoimmune, Immunoglobulins, Thyroid-Stimulating
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