The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection
Open accessAbstract
BACKGROUND/AIM: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection. MATERIALS AND METHODS: Forty patients with hernia disc-originated acute lumbar discogenic pain were evaluated. All patients received a single dose of steroid and local anesthesia mixture epidurally via the lumbar approach. In both groups, Group T (tramadol, n = 20) and Group TG (tramadol + gabapentin, n = 20), the injection dose was adjusted to 4 mL of triamcinolone acetonide and 0.25% bupivacaine mixture. Orally, 75 mg/day tramadol or 75 mg/day tramadol + 900 mg/day gabapentin were added to the treatment. Leukocyte, erythrocyte sedimentation rate, C-reactive protein, and urine serotonin levels were measured prior to and after treatment. The effectiveness of the treatment was evaluated byvisual analog scale (VAS), Oswestry Disability Index (ODI), and straight leg elevation test (SLET). RESULTS: Similar improvements in VAS, ODI, and SLET values were observed in both groups in the second week. The inflammation markers were not different after treatment, neither within the groups nor between the groups. CONCLUSION: This study revealed that tramadol + gabapentin treatment was not superior to tramadol treatment.
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In one study, gabapentin compared with placebo produced a statistically significant difference in leg pain at 2 weeks (MD −0.80; 95% CI −1.53 to −0.07).
“There was a statistically significant difference in leg pain between gabapentin and placebo at 2 weeks (MD −0.80; CI 95% −1.53 to −0.07) in one study.30”
From A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain (2022) · cites this paper as [30]
One gabapentin trial compared gabapentin with placebo, one with no matched intervention, and one compared tramadol with gabapentin plus tramadol.
“Regarding gabapentin trials, one study compared this gabapentinoid with placebo,20 one with no matched intervention,31 and one compared tramadol versus gabapentin plus tramadol.30”
From A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain (2022) · cites this paper as [30]
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- Authors
- PİRBUDAK, L., ÇİÇEK, H., IŞIK, M., & ZER, Y.
- Venue
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2015
- Volume
- 45
- Issue
- 6
- Pages
- 1214-1219
- ISSN
- 1300-0144 (ISSN-L)
- 1303-6165
- OpenAlex
- W2291237144
- Cited by
- 5
- References
- 26
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- TURKISH JOURNAL OF MEDICAL SCIENCES (publishedVersion)
- PubMed (publishedVersion)
- DergiPark (Istanbul University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spine and Intervertebral Disc Pathology
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Keywords
- lumbar disc herniation, epidural steroid injection, tramadol, gabapentin, analgesic combination, acute low back pain, triamcinolone acetonide, bupivacaine, inflammatory markers, urinary serotonin, Oswestry Disability Index, visual analogue scale
- MeSH terms
- Gabapentin, Administration, Oral, Adult, Amines, Analgesics, Anesthetics, Local, Bupivacaine, Cyclohexanecarboxylic Acids, Disability Evaluation, Drug Therapy, Combination, Female, gamma-Aminobutyric Acid, Glucocorticoids, Humans, Injections, Epidural, Intervertebral Disc Displacement, Lumbar Vertebrae, Male, Middle Aged, Prospective Studies, Tramadol, Triamcinolone Acetonide, Single-Blind Method, Low Back Pain, Visual Analog Scale
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