Bone mineral density and growth in children with coeliac disease on a gluten free-diet
Open accessAbstract
BACKGROUND/AIM: To evaluate changes in growth and bone metabolism during consumption of a gluten-free diet (GFD) in children with coeliac disease (CD). MATERIALS AND METHODS: Thirty-seven children with CD (mean age of 8.8 ± 4.6 years, 21 girls) were enrolled. Anthropometric measurements, bone mineral density (BMD) in lumbar 2-4 vertebrae, and serum alkaline phosphatase, calcium, and phosphorus levels at diagnosis and at follow-up were recorded. RESULTS: The mean follow-up period was 3.5 ± 2.3 years. The BMD of patients was significantly lower than that of control subjects at the time of diagnosis but not after 1 year of the GFD. Incidence of low BMD with respect to z-scores for chronological age (CA) was significantly higher than z-scores for height age (HA) (P = 0.006). At the first year of GFD, BMD, BMD z-score, height-for-age z-scores, and weight-for-age z-scores were significantly increased compared with the baseline, but not after 1 year of the GFD. CONCLUSION: In CD, the first year of GFD is important in weight gain, linear growth, and improvement of BMD. A considerable relation of low BMD in children with CD, with respect to z-scores for CA, may be a result of misinterpretation of low BMD due to short stature.
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In children, bone disease is mostly asymptomatic and associated with decreased growth and bone quality.
“and in children bone disease is mostly asymptomatic and associated with decreased growth and bone quality (29).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [29]
The Results (page not supplied) report low bone density in children with coeliac disease, including 2 of 4 with silent disease. The Discussion links low BMD measurements with short stature, but cautions that smaller bone size can make BMD appear low. The paper does not establish that bone disease is mostly asymptomatic or assess bone quality separately from BMD. (LLM, conf=0.84)
Experimental — accuracy not yet measuredNegative TGA is associated with rapid weight recovery but does not seem to have the same long-term effect on catch-up of height.
“Negative TGA is associated with a rapid weight recovery but does not seem to have the same long-term effect on catch-up of height (29, 59, 60).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [29]
The Results and Discussion report that children with low weight reached normal weight ranges on a gluten-free diet, while 3 of 14 initially short children remained short after three years. That supports the contrast in weight and height recovery, but the paper does not link it to negative tissue transglutaminase antibody (TGA) status. The Results also report no difference in weight- or height-for-age scores between children who strictly adhered to the diet and those with occasional gluten intake. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA reduced bone mineral density (BMD) may be present at coeliac disease diagnosis in children and adolescents.
“A reduced bone mineral density (BMD) may be present at CD diagnosis in children and adolescents (29, 32).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [29]
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Research works printed but not linked: 25
- Krupa-Kozak U. Pathologic bone alterations in celiac disease: etiology, epidemiology, and treatment. Nutrition 2014; 30: 16- 24. · DOI
- Larussa T, Suraci E, Nazionale I, Abenavoli L, Imeneo M, Luzza F. Bone mineralization in celiac disease. Gastroenterol Res Pract 2012; 2012: 198025.
- Lucendo AJ, Garcia-Manzanares A. Bone mineral density in adult coeliac disease: an updated review. Rev Esp Enferm Dig 2013; 105: 154-162. · DOI
- Kalayci AG, Kansu A, Girgin N, Kucuk O, Aras G. Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics 2001; 108: E89. · DOI
- Tau C, Mautalen C, De Rosa S, Roca A, Valenzuela X. Bone mineral density in children with celiac disease. Effect of a gluten-free diet. Eur J Clin Nutr 2006; 60: 358-363. · DOI
- Turner J, Pellerin G, Mager D. Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis. J Pediatr Gastroenterol Nutr 2009; 49: 589-593. · DOI
- Sdepanian VL, de Miranda Carvalho CN, de Morais MB, Colugnati FA, Fagundes-Neto U. Bone mineral density of the lumbar spine in children and adolescents with celiac disease on a gluten-free diet in Sao Paulo, Brazil. J Pediatr Gastroenterol Nutr 2003; 37: 571-576. · DOI
- Kemppainen T, Kroger H, Janatuinen E, Arnala I, Lamberg- Allardt C, Karkkainen M, Kosma VM, Julkunen R, Jurvelin J, Alhava E et al. Bone recovery after a gluten-free diet: a 5-year follow-up study. Bone 1999; 25: 355-360. · DOI
- Barera G, Beccio S, Proverbio MC, Mora S. Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten- free diet. Am J Clin Nutr 2004; 79: 148-154.
- Jatla M, Zemel BS, Bierly P, Verma R. Bone mineral content deficits of the spine and whole body in children at time of diagnosis with celiac disease. J Pediatr Gastroenterol Nutr 2009; 48: 175-180. · DOI
- Szathmari M, Tulassay T, Arato A, Bodanszky H, Szabo A, Tulassay Z. Bone mineral content and density in asymptomatic children with coeliac disease on a gluten-free diet. Eur J Gastroenterol Hepatol 2001; 13: 419-424. · DOI
- Gafni RI, Baron J. Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy x-ray absorptiometry (DEXA). J Pediatr 2004; 144: 253-257. · DOI
- Rauch F, Schoenau E. Changes in bone density during childhood and adolescence: an approach based on bone's biological organization. J Bone Miner Res 2001; 16: 597-604. · DOI
- Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-160. · DOI · Paper page
- Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006; 95: 1635-1641. · DOI
- Gokcay G, Furman A, Neyzi O. Updated growth curves for Turkish children aged 15 days to 60 months. Child Care Health Dev 2008; 34: 454-463. · DOI
- Margoni D, Chouliaras G, Duscas G, Voskaki I, Voutsas N, Papadopoulou A, Panayiotou J, Roma E. Bone health in children with celiac disease assessed by dual x-ray absorptiometry: effect of gluten-free diet and predictive value of serum biochemical indices. J Pediatr Gastroenterol Nutr 2012; 54: 680-684. · DOI
- Motta ME, Faria ME, Silva GA. Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment. Sao Paulo Med J 2009; 127: 278-282. · DOI
- Mora S, Barera G, Beccio S, Proverbio MC, Weber G, Bianchi C, Chiumello G. Bone density and bone metabolism are normal after long-term gluten-free diet in young celiac patients. Am J Gastroenterol 1999; 94: 398-403. · DOI
- Kavak US, Yuce A, Kocak N, Demir H, Saltik IN, Gurakan F, Ozen H. Bone mineral density in children with untreated and treated celiac disease. J Pediatr Gastroenterol Nutr 2003, 37: 434-436. · DOI
- Scotta MS, Salvatore S, Salvatoni A, De Amici M, Ghiringhelli D, Broggini M, Nespoli L. Bone mineralization and body composition in young patients with celiac disease. Am J Gastroenterol 1997; 92: 1331-1334.
- Mora S, Barera G, Ricotti A, Weber G, Bianchi C, Chiumello G. Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease. Am J Clin Nutr 1998; 67: 477-481.
- Ciacci C, Maurelli L, Klain M, Savino G, Salvatore M, Mazzacca G, Cirillo M. Effects of dietary treatment on bone mineral density in adults with celiac disease: factors predicting response. Am J Gastroenterol 1997; 92: 992-996.
- Gemme G, Vignolo M, Naselli A, Garzia P. Linear growth and skeletal maturation in subjects with treated celiac disease. J Pediatr Gastroenterol Nutr 1999; 29: 339-342. · DOI
- Patwari AK, Kapur G, Satyanarayana L, Anand VK, Jain A, Gangil A, Balani B. Catch-up growth in children with late- diagnosed coeliac disease. Br J Nutr 2005; 94: 437-442. · DOI
Cited by
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
- Authors
- TUNA KIRSAÇLIOĞLU, C., KULOĞLU, Z., TANCA, A., KÜÇÜK, N. Ö., AYCAN, Z., ÖCAL, G., ENSARİ, A., KALAYCI, A. G., & GİRGİN, N.
- Affiliations
- Ankara University (TR)
- Venue
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2016
- Volume
- 46
- Issue
- 6
- Pages
- 1816-1821
- ISSN
- 1300-0144 (ISSN-L)
- 1303-6165
- OpenAlex
- W2564241554
- Cited by
- 13
- References
- 0
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- TURKISH JOURNAL OF MEDICAL SCIENCES (publishedVersion)
- PubMed (publishedVersion)
- DergiPark (Istanbul University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- celiac disease, gluten-free diet, bone mineral density, child growth, bone metabolism, short stature, height-for-age z-score, weight-for-age z-score, alkaline phosphatase, serum calcium and phosphorus, linear growth
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Female, Glutens, Humans, Male, Absorptiometry, Photon, Bone Density, Diet, Gluten-Free
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