The DOI matches its Crossref record; 63 of the 69 references it cites were found in a registry or an index.
Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials
Open accessAbstract
Background The effect of green tea catechins (GTCs) with or without caffeine on glycemic control is controversial.Objective We aimed to identify and quantify the effects of GTCs or GTC-caffeine mixtures on glucose metabolism in adults.Design A comprehensive literature search was conducted to identify relevant trials of GTCs with or without caffeine on markers of glycemic control [fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (Hb A1c), and homeostatic model assessment of insulin resistance (HOMA-IR)]. Weighted mean differences were calculated for net changes by using fixed-effects models. Prespecified subgroup analyses were performed to explore the influence of covariates on net changes in FBG and FBI concentrations.Results Twenty-two eligible randomized controlled trials with 1584 subjects were identified. Pooled analyses showed that FBG (-1.48 mg/dL; 95% CI: -2.57, -0.40 mg/dL) decreased significantly with GTCs with or without caffeine, whereas FBI (0.04 μU/mL; 95% CI: -0.36, 0.45 μU/mL), Hb A1c (-0.04%; 95% CI: -0.15, 0.08%), and HOMA-IR (-0.05; 95% CI: -0.37, 0.26) did not. Subgroup analyses indicated that the glucose-lowering effect was apparent when the duration of follow-up was over a median of 12 wk. Overall, no significant heterogeneity was detected for FBG, FBI, Hb A1c, or HOMA-IR.Conclusions The meta-analysis showed that the administration of GTCs with or without caffeine resulted in a significant reduction in FBG. The limited data available on GTCs did not support a positive effect on FBI, Hb A1c, or HOMA-IR. Thus, more large and well-designed trials are needed in the future. This trial was registered at http://www.crd.york.ac.uk/prospero as CRD42012002139.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”
From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560
Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., Willett, W. C., & Hu, F. B. (2010) · Diabetes Care · doi:10.2337/dc10-1079 · Cited by 2,116
The chemistry of tea flavonoids
Balentine, D. A., Wiseman, S. A., & Bouwens, L. C. M. (1997) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399709527797 · Cited by 1,130
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s106 · Cited by 1,037
Dulloo, A. G., Duret, C., Rohrer, D., Girardier, L., Mensi, N., Fathi, M., Chantre, P., & Vandermander, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1040 · Cited by 925
Goldstein, D. E., Little, R. R., Lorenz, R. A., Malone, J. I., Nathan, D., Peterson, C. M., & Sacks, D. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1761 · Cited by 625
Bonora, E., Formentini, G., Calcaterra, F., Lombardi, S., Marini, F., Zenari, L., Saggiani, F., Poli, M., Perbellini, S., Raffaelli, A., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1135 · Cited by 604
Research works printed but not linked: 4
- Mirzaei, 2009, Effect of green tea extract on bone turnover markers in type 2 diabetic patients; a double-blind, placebo-controlled clinical trial study, Daru, 17, 38
- Tsuchida, 2002, Reduction of body fat in humans by long-term ingestion of catechins, Prog Med, 22, 2189
- Mohammadi, 2010, The effects of green tea extract on serum adiponectin concentration and insulin resistance in patients with type 2 diabetes mellitus, J Zanjan University of Medical Sciences and Health Services, 18, 44
- Kozuma, 2005, Effect of intake of a beverage containing 540mg catechins on the body composition of obese women and men, Prog Med, 25, 1945
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
The effects of polyphenols and other bioactives on human health
Fraga, C. G., Croft, K. D., Kennedy, D. O., & Tomás-Barberán, F. A. (2019) · Food & Function · doi:10.1039/c8fo01997e · Cited by 1,200
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 794
Dietary factors affecting polyphenol bioavailability
Bohn, T. (2014) · Nutrition Reviews · doi:10.1111/nure.12114 · Cited by 601
Polyphenols and Glycemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2016) · Nutrients · doi:10.3390/nu8010017 · Cited by 583
Metadata
- Authors
- Zheng, X.-X., Xu, Y.-L., Li, S.-H., Hui, R., Wu, Y.-J., & Huang, X.-H.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- ORCID
- Hui, Rutai
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 97
- Issue
- 4
- Pages
- 750-762
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2137040425
- Cited by
- 146
- References
- 69
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 13 · 2018: 11 · 2017: 15 · 2016: 13 · 2015: 7 · 2014: 9 · 2013: 8
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- green tea catechins, caffeine, glycemic control, fasting blood glucose, fasting insulin, HbA1c, insulin resistance, glucose metabolism, type 2 diabetes
- MeSH terms
- Adult, Blood Glucose, Caffeine, Catechin, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Insulin Resistance, Phytotherapy, Metabolic Diseases, Plant Extracts, Camellia sinensis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
