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Cited by 546Body Composition Measurement TechniquesClinical Nutrition and GastroenterologyAdipose Tissue and Metabolism

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure

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Wang, ZiMian, Ying, Zhiliang, Bosy-Westphal, Anja, Zhang, Junyi, Schautz, Britta, Later, Wiebke, Heymsfield, Steven B, Müller, Manfred J·2010·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.2010.29885PMC PMC2980962
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Abstract

Background The specific resting metabolic rates (K(i); in kcal · kg(-1 )· d(-1)) of major organs and tissues in adults were suggested by Elia (in Energy metabolism: tissue determinants and cellular corollaries. New York, NY: Raven Press, 1992) to be as follows: 200 for liver, 240 for brain, 440 for heart and kidneys, 13 for skeletal muscle, 4.5 for adipose tissue, and 12 for residual organs and tissues. However, Elia's K(i) values have never been fully evaluated.Objectives The objectives of the present study were to evaluate the applicability of Elia's K(i) values across adulthood and to explore the potential influence of age on the K(i) values.Design A new approach was developed to evaluate the K(i) values of major organs and tissues on the basis of a mechanistic model: REE = Σ(K(i) × T(i)), where REE is whole-body resting energy expenditure measured by indirect calorimetry, and T(i) is the mass of individual organs and tissues measured by magnetic resonance imaging. With measured REE and T(i), marginal 95% CIs for K(i) values were calculated by stepwise univariate regression analysis. An existing database of nonobese, healthy adults [n = 131; body mass index (in kg/m²) <30] was divided into 3 age groups: 21-30 y (young, n = 43), 31-50 y (middle-age, n = 51), and > 50 y (n = 37).Results Elia's K(i) values were within the range of 95% CIs in the young and middle-age groups. However, Elia's K(i) values were outside the right boundaries of 95% CIs in the >50-y group, which indicated that Elia's study overestimated K(i) values by 3% in this group. Age-adjusted K(i) values for adults aged >50 y were 194 for liver, 233 for brain, 426 for heart and kidneys, 12.6 for skeletal muscle, 4.4 for adipose tissue, and 11.6 for residuals.Conclusion The general applicability of Elia's K(i) values was validated across adulthood, although age adjustment is appropriate for specific applications.

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  1. Terroine, 1925, La respiration des tissue. I. Production calorique des Homeothermas et intensite de la respiration in vitro des homologues. [Tissue respiration. I. Caloric expenditure of Homeotherms and intensity of the in vitro respiration of homologues.], Arch Int Physiol, 24, 356

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Metadata

Authors
Wang, Z., Ying, Z., Bosy-Westphal, A., Zhang, J., Schautz, B., Later, W., Heymsfield, S. B., & Müller, M. J.
Affiliations
  • St. Luke's-Roosevelt Hospital Center (US)
  • Pennington Biomedical Research Center (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2010-12
Volume
92
Issue
6
Pages
1369-1377
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.2010.29885
PMC
PMC2980962
OpenAlex
W2123746079
Cited by
546
References
33
Citations by year
2026: 55 · 2025: 61 · 2024: 52 · 2023: 60 · 2022: 48 · 2021: 56 · 2020: 56 · 2019: 41 · 2018: 38 · 2017: 25 · 2016: 10 · 2015: 14 · 2014: 7 · 2013: 11 · 2012: 6
FWCI
4.76
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK081633, DK081633)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
resting energy expenditure, specific metabolic rate, hepatic metabolism, brain metabolism, skeletal muscle, adipose tissue, healthy adults, indirect calorimetry
MeSH terms
Adipose Tissue, Adult, Age Factors, Basal Metabolism, Brain, Energy Metabolism, Female, Heart, Humans, Kidney, Liver, Male, Middle Aged, Models, Biological, Reference Values, Regression Analysis, Muscle, Skeletal, Young Adult

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