The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Sugar and Fat Bingeing Have Notable Differences in Addictive-like Behavior
Open accessAbstract
Ingestion of different nutrients, such as fats and sugars, normally produces different effects on physiology, the brain, and behavior. However, they do share certain neural pathways for reinforcement of behavior, including the mesolimbic dopamine (DA) system. When these nutrients are consumed in the form of binges, this can release excessive DA, which causes compensatory changes that are comparable to the effects of drugs of abuse. In this article, we review data obtained with animal models of fat and sugar bingeing. The concept of "food addiction" is described and reviewed from both clinical and laboratory animal perspectives. Behavioral manifestations of addictive-like behavior and concomitant alterations in DA and opioid systems are compared for sugar and fat bingeing. Finally, in relation to eating disorders and obesity, we discuss how fat may be the macronutrient that results in excess body weight, and sweet taste in the absence of fat may be largely responsible for producing addictive-like behaviors that include a withdrawal syndrome.
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“certain foods, particularly those rich in sugars and fat, are potently rewarding (13) and can trigger addictive-like behaviours in laboratory animals (14,15).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [15]
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“Such highly palatable and processed foods and their related associations or ‘cues’ stimulate the brain reward and motivation pathways just as reinforcing drugs of abuse and via learning/conditioning mechanisms increase the likelihood of HP food seeking and consumption”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Avena, Rada, & Hoebel, 2009
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633
Well-being : the foundations of hedonic psychology
Kahneman, D. J., Diener, E. F., & Schwarz, N. (1999) · Cited by 7,472
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358
Self-citationOverlapping neuronal circuits in addiction and obesity: evidence of systems pathology
Volkow, N. D., Wang, G.-J., Fowler, J. S., & Telang, F. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0107 · Cited by 809
Images of desire: food-craving activation during fMRI
Pelchat, M. L., Johnson, A., Chan, R., Valdez, J., & Ragland, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.023 · Cited by 667
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Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800
Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load
LaFata, E. M., Avena, N. M., & Gearhardt, A. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117959 · Cited by 712
Self-citationHomeostatic and hedonic signals interact in the regulation of food intake
Lutter, M., & Nestler, E. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.097618 · Cited by 614
Stress as a Common Risk Factor for Obesity and Addiction
Sinha, R., & Jastreboff, A. M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.032 · Cited by 611
Long, C. G., Blundell, J. E., & Finlayson, G. (2015) · Obesity Facts · doi:10.1159/000442403 · Cited by 510
Metadata
- Authors
- Avena, N. M., Rada, P., & Hoebel, B. G.
- Affiliations
- Princeton University (US)
- Corresponding author
- Hoebel, Bartley G.
- ORCID
- Avena, Nicole M.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 139
- Issue
- 3
- Pages
- 623-628
- ISSN
- 0022-3166 (ISSN-L)
- PMC
- PMC2714381
- OpenAlex
- W2138737041
- Cited by
- 388
- References
- 73
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 14 · 2021: 24 · 2020: 62 · 2019: 19 · 2018: 25 · 2017: 21 · 2016: 25 · 2015: 28 · 2014: 22 · 2013: 23 · 2012: 38
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (AA12882)
- National Institute on Alcohol Abuse and Alcoholism (AA12882, R01AA012882)
- National Institute on Drug Abuse
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-79793, F32DK079793)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- food addiction, mesolimbic dopamine system, opioid system, eating disorders, obesity, sweet taste, withdrawal syndrome, macronutrients
- MeSH terms
- Animals, Bulimia, Dietary Carbohydrates, Dietary Fats, Humans, Rats
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