The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Iron Supplementation Benefits Physical Performance in Women of Reproductive Age: A Systematic Review and Meta-Analysis
Open accessAbstract
Animal and human observational studies suggest that iron deficiency impairs physical exercise performance, but findings from randomized trials on the effects of iron are equivocal. Iron deficiency and anemia are especially common in women of reproductive age (WRA). Clear evidence of benefit from iron supplementation would inform clinical and public health guidelines. Therefore, we performed a systematic review and meta-analysis to determine the effect of iron supplementation compared with control on exercise performance in WRA. We searched the Cochrane Central Register of Clinical Trials, MEDLINE, Scopus (comprising Embase and MEDLINE), WHO regional databases, and other sources in July 2013. Randomized controlled trials that measured exercise outcomes in WRA randomized to daily oral iron supplementation vs. control were eligible. Random-effects meta-analysis was used to calculate mean differences (MDs) and standardized MDs (SMDs). Risk of bias was assessed using the Cochrane risk-of-bias tool. Of 6757 titles screened, 24 eligible studies were identified, 22 of which contained extractable data. Only 3 studies were at overall low risk of bias. Iron supplementation improved both maximal exercise performance, demonstrated by an increase in maximal oxygen consumption (VO2 max) [for relative VO2 max, MD: 2.35 mL/(kg ⋅ min); 95% CI: 0.82, 3.88; P = 0.003, 18 studies; for absolute VO2 max, MD: 0.11 L/min; 95% CI: 0.03, 0.20; P = 0.01, 9 studies; for overall VO2 max, SMD: 0.37; 95% CI: 0.11, 0.62; P = 0.005, 20 studies], and submaximal exercise performance, demonstrated by a lower heart rate (MD: -4.05 beats per minute; 95% CI: -7.25, -0.85; P = 0.01, 6 studies) and proportion of VO2 max (MD: -2.68%; 95% CI: -4.94, -0.41; P = 0.02, 6 studies) required to achieve defined workloads. Daily iron supplementation significantly improves maximal and submaximal exercise performance in WRA, providing a rationale to prevent and treat iron deficiency in this group. This trial was registered with PROSPERO (http://www.crd.york.ac.uk/PROSPERO/prospero.asp) as CRD42013005166.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, a meta-analysis gathering data from 15 studies carried out in endurance athletes found a moderate but significant favorable effect on VO2max of iron intervention (oral iron in most studies, with dosages varying from 10 to 300 mg/day and for durations ranging from 14 to 84 days).”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [132]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
Cochrane Handbook for Systematic Reviews of Interventions
Tarsilla, M. (2010) · Journal of MultiDisciplinary Evaluation · doi:10.56645/jmde.v6i14.284 · Cited by 5,232
Assessing Risk of Bias in Included Studies
Higgins, J. P., & Altman, D. G. (2008) · Cochrane Handbook for Systematic Reviews of Interventions · doi:10.1002/9780470712184.ch8 · Cited by 3,396
Stevens, G. A., Finucane, M. M., De‐Regil, L. M., Paciorek, C., Flaxman, S. R., Branca, F., Peña‐Rosas, J. P., Bhutta, Z. A., & Ezzati, M. (2013) · The Lancet Global Health · doi:10.1016/s2214-109x(13)70001-9 · Cited by 1,977
Self-citationHaas, J. D., & Brownlie, T. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.676s · Cited by 1,186
Nutrition and Athletic Performance
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31890eb86 · Cited by 1,084 · cited 2×
“hemolysis, and increased iron losses in sweat, urine, and feces (44).”
BackgroundGuidelines for the management of iron deficiency anaemia
Goddard, A. F., James, M. W., McIntyre, A. S., & SCOTT, B. B. (2011) · Gut · doi:10.1136/gut.2010.228874 · Cited by 968
The maximally attainable V̇ o 2during exercise in humans: the peak vs. maximum issue
Day, J. R., Rossiter, H. B., Coats, E. M., Skasick, A., & Whipp, B. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00024.2003 · Cited by 482
Ljungqvist, A., Jenoure, P., Engebretsen, L., Alonso, J. M., Bahr, R., Clough, A., de Bondt, G., Dvořák, J., Maloley, R., Matheson, G. O., et al. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.064394 · Cited by 444
Research works printed but not linked: 4
- Pasricha, 2013, Effects of daily iron supplementation on physical exercise performance in women of reproductive age: systematic review and meta-analysis.
- Donoso, 1984, Effect of therapy in physical work capacity of iron deficient female athletes: a double blind, randomized, controlled study., Fed Proc., 43
- Walsh, 1989, Effect of iron supplementation on iron status of young female swimmers during the pre-phase of competition., J Swimming Research., 5, 13
- Walsh, 1989, Serum iron levels in young female swimmers during pre-season phase of competition and the effects of iron supplementation upon them., J Hum Mov Stud., 17, 229
Cited by
Sorted by citations
Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678
Biomarkers of Nutrition for Development—Folate Review
Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,170
Pasricha, S.-R., Tye-Din, J., Muckenthaler, M. U., & Swinkels, D. W. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32594-0 · Cited by 1,069
Self-citationDaily oral iron supplementation during pregnancy
Peña‐Rosas, J. P., De‐Regil, L. M., Dowswell, T., & Viteri, F. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004736.pub4 · Cited by 614
Self-citationDaily oral iron supplementation during pregnancy
Peña-Rosas, J. P., De-Regil, L. M., Garcia-Casal, M. N., & Dowswell, T. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004736.pub5 · Cited by 565
Self-citation
Metadata
- Authors
- Pasricha, S.-R., Low, M., Thompson, J., Farrell, A., & De-Regil, L.-M.
- Affiliations
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- The University of Adelaide (AU)
- Monash Health (AU)
- Corresponding author
- Pasricha, Sant-Rayn
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 144
- Issue
- 6
- Pages
- 906-914
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2127091926
- Cited by
- 158
- References
- 60
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 14 · 2023: 21 · 2022: 10 · 2021: 17 · 2020: 10 · 2019: 11 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 5
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Vifor Pharma
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- iron supplementation, iron deficiency, women of reproductive age, exercise performance, VO2max, submaximal exercise, heart rate, anemia, iron deficiency prevention, oral iron, physical fitness, pregnancy and lactation, iron deficiency screening
- MeSH terms
- Female, Humans, Oxygen Consumption, Reproduction, Exercise, Randomized Controlled Trials as Topic, Anemia, Iron-Deficiency, Iron, Dietary, Dietary Supplements, Observational Studies as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
