The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Bisphosphonate-related atypical femoral fracture: Managing a rare but serious complication
Open accessAbstract
Atypical femoral fracture is a rare but serious complication of long-term bisphosphonate therapy. Although the benefit of preventing osteoporotic fractures greatly outweighs the risk of atypical fracture in bisphosphonate users, concern about atypical fracture risk has led to a decrease in bisphosphonate use. What are the risks, and how do we treat atypical femoral fracture?
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Prolonged use of these substances alters the balance between bone resorption and bone formation, favoring bone formation at first but then shifting over time to favor bone resorption.
“The prolonged use of these substances alters the balance between bone resorption and bone formation, favoring bone formation at first but then shifting over time to favor bone resorption.”
From Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics (2023) · cites this paper as [95]
The ‘What Is the Underlying Pathophysiology?’ section describes bisphosphonates as antiresorptive drugs that suppress bone turnover. It says prolonged use could suppress turnover too much, not that it shifts the balance toward bone resorption. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredAtypical femoral shaft fractures occur from the prolonged use of resorptive agents, including bisphosphonates, denosumab, and some SERMs.
“Atypical femoral shaft fractures occur from the prolonged use of resorptive agents, some of which have been mentioned above (bisphosphonates, denosumab, and some SERMs) [95].”
From Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics (2023) · cites this paper as [95]
The “Absolute risk is low but increases with longer use” section (page unavailable) reports that atypical femoral fracture risk rises with the duration of bisphosphonate use. The “Medications” section (page unavailable) also associates denosumab with these fractures, but does not establish a prolonged-use relationship for it. The cited passages do not identify SERMs as associated drugs, and describe increased risk or association rather than fractures invariably resulting from treatment. (LLM, conf=0.88)
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Metadata
- Authors
- Silverman, S., Kupperman, E., & Bukata, S.
- Affiliations
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Venue
- Cleveland Clinic Journal of Medicine
- Publisher
- Cleveland Clinic Journal of Medicine
- Published
- 2018-11
- Volume
- 85
- Issue
- 11
- Pages
- 885-893
- ISSN
- 0891-1150 (ISSN-L)
- 1939-2869
- OpenAlex
- W2899542159
- Cited by
- 34
- References
- 52
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 4
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cleveland Clinic Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Keywords
- atypical femoral fractures, bisphosphonates, osteoporotic fracture prevention, fracture risk, bisphosphonate discontinuation, fracture treatment
- MeSH terms
- Aged, Diphosphonates, Female, Femoral Fractures, Humans, Male, Osteoporosis, Time Factors, Bone Density Conservation Agents, Osteoporotic Fractures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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