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Cited by 443

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Cerebral Amyloid Angiopathy: A Systematic Review

Open access
Biffi, Alessandro, Greenberg, Steven M.·2011·Journal of Clinical Neurology

Abstract

Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system. CAA occurs mostly as a sporadic condition in the elderly, its incidence associating with advancing age. All sporadic CAA cases are due to deposition of amyloid-β, originating from proteolytic cleavage of the Amyloid Precursor Protein. Hereditary forms of CAA are generally familial (and therefore rare in the general population), more severe and earlier in onset. CAA-related lobar intracerebral hemorrhage is the most well-studied clinical condition associated with brain amyloid deposition. Despite ever increasing understanding of CAA pathogenesis and availability of reliable clinical and diagnostic tools, preventive and therapeutic options remain very limited. Further research efforts are required in order to identify biological targets for novel CAA treatment strategies. We present a systematic review of existing evidence regarding the epidemiology, genetics, pathogenesis, diagnosis and clinical management of CAA.

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Metadata

Authors
Biffi, A., & Greenberg, S. M.
Venue
Journal of Clinical Neurology
Publisher
XMLink
Published
2011
Volume
7
Issue
1
Pages
1
ISSN
1738-6586 (ISSN-L)
OpenAlex
W2144913309
Cited by
443
References
90
FWCI
2.52
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Cerebral Amyloid Angiopathy: A Systematic Review. https://app.cochat.ai/papers/10.3988/jcn.2011.7.1.1
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Biffi, A., & Greenberg, S. M. (2011). Cerebral Amyloid Angiopathy: A Systematic Review. Journal of Clinical Neurology. https://doi.org/10.3988/jcn.2011.7.1.1

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.