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The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

The Diagnosis and Treatment of Autoimmune Encephalitis

Open access
Lancaster, Eric·2016·Journal of Clinical Neurology

Abstract

Autoimmune encephalitis causes subacute deficits of memory and cognition, often followed by suppressed level of consciousness or coma.A careful history and examination may show early clues to particular autoimmune causes, such as neuromyotonia, hyperekplexia, psychosis, dystonia, or the presence of particular tumors.Ancillary testing with MRI and EEG may be helpful for excluding other causes, managing seizures, and, rarely, for identifying characteristic findings.Appropriate autoantibody testing can confirm specific diagnoses, although this is often done in parallel with exclusion of infectious and other causes.Autoimmune encephalitis may be divided into several groups of diseases: those with pathogenic antibodies to cell surface proteins, those with antibodies to intracellular synaptic proteins, T-cell diseases associated with antibodies to intracellular antigens, and those associated with other autoimmune disorders.Many forms of autoimmune encephalitis are paraneoplastic, and each of these conveys a distinct risk profile for various tumors.Tumor screening and, if necessary, treatment is essential to proper management.Most forms of autoimmune encephalitis respond to immune therapies, although powerful immune suppression for weeks or months may be needed in difficult cases.Autoimmune encephalitis may relapse, so follow-up care is important.Key Wordszz autoimmune, antibody, paraneoplastic, encephalitis, anti-NMDAR encephalitis. The Diagnosis and Treatment of Autoimmune EncephalitisAutoimmune encephalitis involves several types of diseases with different pathophysiology.Understanding the pathophysiology of these diseases is helpful in using diagnostic testing and choosing appropriate therapies.The first group includes the classic paraneoplastic disorders associated with antibodies to intracellular antigens, such as anti-Hu.These disorders are strongly cancer associated and involve T-cell responses targeting neu-

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Metadata

Authors
Lancaster, E.
Venue
Journal of Clinical Neurology
Publisher
XMLink
Published
2016
Volume
12
Issue
1
Pages
1
ISSN
  • 1738-6586 (ISSN-L)
  • 2005-5013
OpenAlex
W2225011328
Cited by
437
References
76
FWCI
33.04
Type
journal article
Language
en
Open access
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Lancaster, E. (2016). The Diagnosis and Treatment of Autoimmune Encephalitis. Journal of Clinical Neurology. https://doi.org/10.3988/jcn.2016.12.1.1

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