Probiotic Mixture KF Attenuates Age-Dependent Memory Deficit and Lipidemia in Fischer 344 Rats
Abstract
To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 10(11) CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 10(10) CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.
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Lactobacillus strains restore spatial memory impairments induced by diet in immunodeficient mice, age, hyperammonemia, and gut microbiota depletion after chronic antibiotic treatment.
“These strains also proved effective in restoring spatial memory impairments induced by diet in immunodeficient mice (Ohland et al., 2013), age (Jeong et al., 2015), hyperammonemia (Luo et al., 2014), and by gut microbiota depletion after chronic antibiotic treatment (Wang et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Jeong et al., 2015
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- Authors
- Jeong, J.-J., Kim, K.-A., Ahn, Y.-T., Sim, J.-H., Woo, J.-Y., Huh, C.-S., & Kim, D.-H.
- Affiliations
- Kyung Hee University (KR)
- Korea Yakult (South Korea) (KR)
- Seoul National University (KR)
- Corresponding author
- Kim, Dong-Hyun
- Venue
- Journal of Microbiology and Biotechnology
- Published
- 2015-09-28
- Volume
- 25
- Issue
- 9
- Pages
- 1532-1536
- ISSN
- 1017-7825 (ISSN-L)
- 1738-8872
- OpenAlex
- W2303977262
- Cited by
- 33
- References
- 0
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- lactic acid bacteria, Lactobacillus plantarum, Lactobacillus curvatus, lipidemia, triglycerides, HDL cholesterol, spontaneous alternation, doublecortin, brain-derived neurotrophic factor, NF-κB activation, hippocampus, aging, F344 rats
- MeSH terms
- Doublecortin Protein, Administration, Oral, Animals, Hippocampus, Hyperlipidemias, Lactobacillus, Cholesterol, HDL, Memory Disorders, Rats, Inbred F344, Triglycerides, Probiotics
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