Cited by 67Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations

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Salami, Mahmoud·2021·Frontiers in Neuroscience

Abstract

The human gastrointestinal tract hosts trillions of microorganisms that is called "gut microbiota." The gut microbiota is involved in a wide variety of physiological features and functions of the body. Thus, it is not surprising that any damage to the gut microbiota is associated with disorders in different body systems. Probiotics, defined as living microorganisms with health benefits for the host, can support or restore the composition of the gut microbiota. Numerous investigations have proved a relationship between the gut microbiota with normal brain function as well as many brain diseases, in which cognitive dysfunction is a common clinical problem. On the other hand, increasing evidence suggests that the existence of a healthy gut microbiota is crucial for normal cognitive processing. In this regard, interplay of the gut microbiota and cognition has been under focus of recent researches. In the present paper, I review findings of the studies considering beneficial effects of either gut microbiota or probiotic bacteria on the brain cognitive function in the healthy and disease statuses.

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  1. Iversen S. Dunnett S. Bjorklund A. (2010). Dopamine Handbook. Oxford: Oxford University Press.

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Authors
Salami, M.
Affiliations
Kashan University of Medical Sciences (IR)
Corresponding author
Salami, Mahmoud
Venue
Frontiers in Neuroscience
Published
2021-02-11
Volume
15
Pages
613120-613120
ISSN
1662-453X (ISSN-L)
OpenAlex
W3128788375
Cited by
67
References
390
Citations by year
2026: 5 · 2025: 16 · 2024: 9 · 2023: 12 · 2022: 19 · 2021: 4 · 2017: 1
FWCI
1.15
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, probiotics, cognitive function, gut-brain axis, central nervous system, cognitive impairment, brain disorders, beneficial bacteria

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