Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine-Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-��B Activation
Abstract
CJLJ103 (LJ) could alleviate cholinergic memory impairment in mice. Oral administration of LJ alleviated scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-α expression and NF-κB activation. LJ also increased BDNF expression in corticosterone-stimulated SH-SY5Y cells and inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. However, LJ did not inhibit acetylcholinesterase activity. These findings suggest that LJ, a member of human gut microbiota, may mitigate cholinergic memory impairment by increasing BDNF expression and inhibiting NF-κB activation.
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From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [96]
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- Authors
- Lee, H.-J., Lim, S.-M., & Kim, D.-H.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Kim, Dong-Hyun
- Venue
- Journal of Microbiology and Biotechnology
- Published
- 2018-09-28
- Volume
- 28
- Issue
- 9
- Pages
- 1443-1446
- ISSN
- 1017-7825 (ISSN-L)
- 1738-8872
- OpenAlex
- W2979121980
- Cited by
- 32
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- scopolamine-induced amnesia, brain-derived neurotrophic factor, NF-κB activation, CREB phosphorylation, hippocampus, gut microbiota, TNF-α, microglia, acetylcholinesterase, passive avoidance, Y-maze
- MeSH terms
- Lactobacillus johnsonii, Animals, Cell Line, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Humans, Male, Memory Disorders, Mice, Inbred ICR, Phosphorylation, Scopolamine, Tumor Necrosis Factor-alpha, NF-kappa B, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Probiotics, Mice
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