Biomechanics of Synthetic Elastin: Insights from Magnetic Resonance Microimaging
Open accessAbstract
We used Magnetic Resonance microimaging (MRI) to study the compressive behaviour of synthetic elastin. Compression-induced changes in the elastin sample were quantified using longitudinal and transverse spin relaxation rates (R1 and R2, respectively). Spatially-resolved maps of each spin relaxation rate were obtained, allowing the heterogeneous texture of the sample to be observed with and without compression. Compression resulted in an increase of both the mean R1 and the mean R2, but most of this increase was due to sub-locations that exhibited relatively low R1 and R2 in the uncompressed state. This behaviour can be described by differential compression, where local domains in the hydrogel with a relatively low biopolymer content compress more than those with a relatively high biopolymer content.
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Elastic fibres are formed from soluble tropoelastin molecules via cross-linking, generating an amorphous, insoluble and stabilized polymeric structure that confers elasticity to the skin.
“In resume, elastic fibres are formed from several soluble tropoelastin molecules, an elastin precursor in its monomeric form via cross-linking, and generate an amorphous, insoluble and stabilized polymeric structure that confers elasticity to the skin [33, 35, 37, 45, 46].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [35]
The Introduction (page unavailable) says elastin consists of cross-linked networks built mainly from water-soluble tropoelastin and contributes to the elasticity of tissues including skin. Materials and Methods (page unavailable) also describes assembling tropoelastin into cross-linked elastin. Our copy does not establish the additional descriptions of the resulting structure as amorphous, insoluble, or stabilized. (LLM, conf=0.86)
Experimental — accuracy not yet measuredElastin is a protein present in several connective tissues and confers unique physiological elasticity.
“Similar to other molecular components of the extracellular matrix such as collagen, fibrillin, fibulin, fibrinogen, fibronectin, laminin, tenascin and thrombospondin, elastin is a protein that is present in several connective tissues and confers a unique physiological elasticity [33 -36].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [35]
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Elastin structure and its involvement in skin photoageing
Weihermann, A. C., Lorencini, M., Brohem, C. A., & de Carvalho, C. M. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12372 · Cited by 195 · see citing works
Kamaruzaman, N., & Yusop, S. M. (2021) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101519 · Cited by 33 · see citing works
Kamaruzaman, N., Fauzi, M. B., & Yusop, S. M. (2022) · Polymers · doi:10.3390/polym14050963 · Cited by 17 · see citing works
Sustainability and Zooceuticals: Cosmetic Ingredients Derived from Animals
Ijaz, M. U., Hayat, M. F., Ashraf, A., Mirza, S. S., Javed, S., & Arshad, M. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-86087-4_5 · Cited by 3 · see citing works
Le vieillissement dans les modèles de peau humaine reconstruite
Capallere, C. (2019) · theses.fr (ABES) · doi:10.70675/c369a08bz4786z44d5za233z3e25f161b119
- Authors
- Momot, K. I., Powell, S. K., Mithieux, S. M., & Weiss, A. S.
- Affiliations
- Queensland University of Technology (AU)
- The University of Sydney (AU)
- Venue
- Advanced Materials Research
- Publisher
- Trans Tech Publications, Ltd.
- Published
- 2013-05
- Volume
- 699
- Pages
- 457-463
- ISSN
- 1022-6680 (ISSN-L)
- 1662-8985
- OpenAlex
- W2046168774
- Cited by
- 5
- References
- 7
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2016: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.qut.edu.au
- Licence
- Locations
- Advanced materials research (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Science & Engineering Faculty
- Topics
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- hydrogels, compressive properties, spin relaxation rate, differential compression, tissue engineering scaffolds
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