The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Oral Health and Care in the Intensive Care Unit: State of the Science
Abstract
Oral health is influenced by oral microbial flora, which are concentrated in dental plaque. Dental plaque provides a microhabitat for organisms and an opportunity for adherence of the organisms to either the tooth surface or other microorganisms. In critically ill patients, potential pathogens can be cultured from the oral cavity. These microorganisms in the mouth can translocate and colonize the lung, resulting in ventilator-associated pneumonia. The importance of oral care in the intensive care unit has been noted in the literature, but little research is available on mechanical or pharmacological approaches to reducing oral microbial flora via oral care in critically ill adults. Most research in oral care has been directed toward patients' comfort; the microbiological and physiological effects of tooth brushing in the intensive care unit have not been reported. Although 2 studies indicated reductions in rates of ventilator-associated pneumonia in cardiac surgery patients who received chlorhexidine before intubation and postoperatively, the effects of chlorhexidine in reducing ventilator-associated pneumonia in other populations of critically ill patients or its effect when treatment with the agent initiated after intubation have not been reported. In addition, no evaluation of the effectiveness of pharmacological and mechanical interventions relative to each other or in combination has been published. Additional studies are needed to develop and test best practices for oral care in critically ill patients.
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“becomes overrun by potentially pathogenic bacteria, including prominent Proteobacteria, such as P aeruginosa and K pneumoniae.”
From The microbiome and critical illness (2016) · cites this paper as [81]
Citations
Cites
Cellular and Molecular Immunology
Abbas, A. K., Lichtman, A. H., & Pillai, S. S. (1994) · Cited by 3,571
Oral Health in America: A Report of the Surgeon General
(2000) · Journal of the California Dental Association · doi:10.1080/19424396.2000.12223118 · Cited by 2,484
Systemic Diseases Caused by Oral Infection
Li, X., Kolltveit, K. M., Tronstad, L., & Olsen, I. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.4.547 · Cited by 1,292
Role of Oral Bacteria in Respiratory Infection
Scannapieco, F. A. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.7.793 · Cited by 653
Guideline for Prevention of Nosocomial Pneumonia
Tablan, O. C., Anderson, L. J., Arden, N. H., Breiman, R. F., Butler, J. C., & McNeil, M. M. (1994) · Infection Control and Hospital Epidemiology · doi:10.1086/646989 · Cited by 578
Continuous Aspiration of Subglottic Secretions in Preventing Ventilator-Associated Pneumonia
Vallés, J., Artigas, A., Rello, J., Bonsoms, N., Fontanals, D., Blanch, L. L., Fernández, R., Baigorri, F., & Mestre, J. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-3-199502010-00004 · Cited by 546
DeRiso, A. J., Ladowski, J. S., Dillon, T. A., Justice, J. W., & Peterson, A. C. (1996) · CHEST Journal · doi:10.1378/chest.109.6.1556 · Cited by 492
Colonization of dental plaque by respiratory pathogens in medical intensive care patients
Scannapieco, F. A., Stewart, E., & Mylotte, J. M. (1992) · Critical Care Medicine · doi:10.1097/00003246-199206000-00007 · Cited by 384
Lactoferrin is a lipid A-binding protein
Appelmelk, B. J., An, Y. Q., Geerts, M., Thijs, B. G., de Boer, H. A., MacLaren, D. M., Graaff, J., & Nuijens, J. H. (1994) · Infection and Immunity · doi:10.1128/iai.62.6.2628-2632.1994 · Cited by 362
Scannapieco, F. A., & Ho, A. W. (2001) · Journal of Periodontology · doi:10.1902/jop.2001.72.1.50 · Cited by 296
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Research works printed but not linked: 4
- Kerr V . Bacteraemia. Br Dent J. 2000;188:355–356.
- Gipe B , Donnelly D, Harris S. A survey of dental health in patients with respiratory failure [abstract]. Am J Res Crit Care Med. 1995;151:A340.
- Munro CL , Grap MJ, Hummel R, Elswick RK, Sessler C. Oral health status: effect on VAP [abstract]. Am J Crit Care. 2002;11:280.
- Roitt I , Brostoff J, Male D. Immunology. 5th ed. St Louis, Mo: Mosby; 1998.
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Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2906 · Cited by 618
The microbiome and critical illness
Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460
Ventilator-Associated Pneumonia in Neonatal and Pediatric Intensive Care Unit Patients
Foglia, E. E., Meier, M. D., & Elward, A. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00041-06 · Cited by 314
Munro, C. L., Grap, M. J., Jones, D. J., McClish, D. K., & Sessler, C. N. (2009) · American Journal of Critical Care · doi:10.4037/ajcc2009792 · Cited by 246
Self-citationCason, C. L., Tyner, T. E., Saunders, S., & Broome, L. (2007) · American Journal of Critical Care · doi:10.4037/ajcc2007.16.1.28 · Cited by 181
Metadata
- Authors
- Munro, C. L., & Grap, M. J.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- American Journal of Critical Care
- Publisher
- AACN Publishing
- Published
- 2004-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 25-34
- ISSN
- 1062-3264 (ISSN-L)
- 1937-710X
- OpenAlex
- W2141434923
- Cited by
- 276
- References
- 85
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 16 · 2019: 8 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 17 · 2014: 20 · 2013: 14 · 2012: 12
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Critical Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Nursing Research (R01NR07652, R01NR007652)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Keywords
- oral care, intensive care unit, critically ill patients, oral microbiota, dental plaque, ventilator-associated pneumonia, chlorhexidine, toothbrushing, oral colonization, cardiac surgery patients
- MeSH terms
- Chlorhexidine, Critical Care, Dental Plaque, Disinfectants, Humans, Intensive Care Units, Mouth, Oral Health, Pneumonia, Respiration, Artificial, Toothbrushing
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