The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production
Abstract
Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. We hypothesized that chitin is a size-dependent regulator of innate immunity. To test this hypothesis, we characterized the effects of chitins of different sizes on murine bronchoalveolar or peritoneal macrophages. In these studies, large chitin fragments were inert, while both intermediate-sized chitin (40–70 μm) and small chitin (SC; <40 μm, largely 2–10 μm) stimulated TNF elaboration. In contrast, only SC induced IL-10 elaboration. The effects of intermediate-sized chitin were mediated by pathways that involve TLR2, dectin-1, and NF-κB. In contrast, the effects of SC were mediated by TLR2-dependent and -independent, dectin-1-dependent pathways that involved the mannose receptor and spleen tyrosine kinase. Chitin contains size-dependent pathogen-associated molecular patterns that stimulate TLR2, dectin-1, and the mannose receptor, differentially activate NF-κB and spleen tyrosine kinase, and stimulate the production of pro- and anti-inflammatory cytokines.
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Dectin-1: a signalling non-TLR pattern-recognition receptor
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Self-citationGENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
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Chitin induces accumulation in tissue of innate immune cells associated with allergy
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Gow, N. A. R., Latge, J.-P., & Munro, C. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0035-2016 · Cited by 1,423
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
Garcia-Rubio, R., de Oliveira, H. C., Rivera, J., & Trevijano-Contador, N. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02993 · Cited by 917
Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Lee, C. G., Da Silva, C. A., Dela Cruz, C. S., Ahangari, F., Ma, B., Kang, M.-J., He, C.-H., Takyar, S., & Elias, J. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142250 · Cited by 896
Self-citationBiomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Interactions of fungal pathogens with phagocytes
Erwig, L. P., & Gow, N. A. R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.21 · Cited by 626
Metadata
- Authors
- Da Silva, C. A., Chalouni, C., Williams, A., Hartl, D., Lee, C. G., & Elias, J. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 182
- Issue
- 6
- Pages
- 3573-3582
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1672848901
- Cited by
- 279
- References
- 33
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Da Silva, C. A., Chalouni, C., Williams, A., Hartl, D., Lee, C. G., & Elias, J. A. (2009). Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0802113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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