The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nitrated α-Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets
Open accessAbstract
Microglial inflammatory neuroregulatory activities affect the tempo of nigrostriatal degeneration during Parkinson’s disease (PD). Such activities are induced, in part, by misfolded, nitrated α-synuclein (N-α-syn) within Lewy bodies released from dying or dead dopaminergic neurons. Such pathobiological events initiate innate and adaptive immune responses affecting neurodegeneration. We posit that the neurobiological activities of activated microglia are affected by cell-protein and cell-cell contacts, in that microglial interactions with N-α-syn and CD4+ T cells substantively alter the microglial proteome. This leads to alterations in cell homeostatic functions and disease. CD4+CD25+ regulatory T cells suppress N-α-syn microglial-induced reactive oxygen species and NF-κB activation by modulating redox-active enzymes, cell migration, phagocytosis, and bioenergetic protein expression and cell function. In contrast, CD4+CD25− effector T cells exacerbate microglial inflammation and induce putative neurotoxic responses. These data support the importance of adaptive immunity in the regulation of Parkinson’s disease-associated microglial inflammation.
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Alterations of T-lymphocyte populations in Parkinson disease
Baba, Y., Kuroiwa, A., Uitti, R. J., Wszolek, Z. K., & Yamada, T. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.07.005 · Cited by 336
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Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia
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The effects of aging, injury and disease on microglial function: a case for cellular senescence
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Cited by
Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045
Neuroinflammation in Parkinson's disease
Hirsch, E. C., Vyas, S., & Hunot, S. (2012) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70065-7 · Cited by 657
ROS and Brain Diseases: The Good, the Bad, and the Ugly
Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963520 · Cited by 427
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Neuroinflammation: Microglia and T Cells Get Ready to Tango
Schetters, S. T. T., Gomez-Nicola, D., Garcia-Vallejo, J. J., & Van Kooyk, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01905 · Cited by 382
Metadata
- Authors
- Reynolds, A. D., Stone, D. K., Mosley, R. L., & Gendelman, H. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-01
- Volume
- 182
- Issue
- 7
- Pages
- 4137-4149
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2160733114
- Cited by
- 197
- References
- 8
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Reynolds, A. D., Stone, D. K., Mosley, R. L., & Gendelman, H. E. (2009). Nitrated α-Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0803982
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