CoChat
Sign Up
Cited by 427Antioxidant Activity and Oxidative StressRedox biology and oxidative stressNeurological Disorders and Treatments

ROS and Brain Diseases: The Good, the Bad, and the Ugly

Open access
Popa-Wagner, Aurel, Mitran, Smaranda, Sivanesan, Senthilkumar, Chang, Edwin, Buga, Ana-Maria·2013·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2013/963520PMC PMC3871919
Open this paper in CoChat — free accountOpen PDF

Abstract

The brain is a major metabolizer of oxygen and yet has relatively feeble protective antioxidant mechanisms. This paper reviews the Janus-faced properties of reactive oxygen species. It will describe the positive aspects of moderately induced ROS but it will also outline recent research findings concerning the impact of oxidative and nitrooxidative stress on neuronal structure and function in neuropsychiatric diseases, including major depression. A common denominator of all neuropsychiatric diseases including schizophrenia and ADHD is an increased inflammatory response of the brain caused either by an exposure to proinflammatory agents during development or an accumulation of degenerated neurons, oxidized proteins, glycated products, or lipid peroxidation in the adult brain. Therefore, modulation of the prooxidant-antioxidant balance provides a therapeutic option which can be used to improve neuroprotection in response to oxidative stress. We also discuss the neuroprotective role of the nuclear factor erythroid 2-related factor (Nrf2) in the aged brain in response to oxidative stressors and nanoparticle-mediated delivery of ROS-scavenging drugs. The antioxidant therapy is a novel therapeutic strategy. However, the available drugs have pleiotropic actions and are not fully characterized in the clinic. Additional clinical trials are needed to assess the risks and benefits of antioxidant therapies for neuropsychiatric disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2013/963520

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Damages caused by oxidative stress in the mitochondria are associated or responsible for diseases such as schizophrenia, autism, depression, and anxiety.

    “It has been found that damages caused by oxidative stress in the mitochondria are associated or responsible for diseases, such as schizophrenia, autism, depression, and anxiety99.”

    From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [99]

    Section 4, “Brain Mitochondrion and Oxidative Stress” (page not provided), links oxidative stress and mitochondrial abnormalities to neuropsychiatric disorders, identifies oxidative-stress markers in schizophrenia and anxiety-related disorders, and reports mitochondrial dysfunction in autism and schizophrenia. Section 6.2 links oxidative stress to depression, but the cited passages do not establish that mitochondrial oxidative damage is responsible for all four conditions. The causal wording is stronger than the review’s largely associative account. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 162

  1. [1]Dole M The natural history of oxygen The Journal of General Physiology 1965 49 1 5 27 2-s2.0-0013802107 PMC2195461 5859927
  2. [2]Campbell NA Reece JB Biology 2005 7th edition Pearson-Benjamin Cummings
  3. [3]Rich PR The molecular machinery of Keilin’s respiratory chain Biochemical Society Transactions 2003 31 6 1095 1105 2-s2.0-0347419305 14641005
  4. [4]Guglielmotto M Tamagno E Danni O Oxidative stress and hypoxia contribute to Alzheimer’s disease pathogenesis: two sides of the same coin TheScientificWorldJournal 2009 9 1 781 791 2-s2.0-70350767274 PMC5823176 19705038
  5. [5]Chen S-D Yang D-I Lin T-K Shaw F-Z Liou C-W Chuang Y-C Roles of oxidative stress, apoptosis, PGC-1 and mitochondrial biogenesis in cerebral ischemia International Journal of Molecular Sciences 2011 12 10 7199 7215 2-s2.0-80055029604 22072942 PMC3211033
  6. [6]Valko M Leibfritz D Moncol J Cronin MTD Mazur M Telser J Free radicals and antioxidants in normal physiological functions and human disease International Journal of Biochemistry and Cell Biology 2007 39 1 44 84 2-s2.0-33749986298 16978905
  7. [8]Wang X Zhao X Contribution of oxidative damage to antimicrobial lethality Antimicrobial Agents and Chemotherapy 2009 53 4 1395 1402 2-s2.0-65649104513 19223646 PMC2663088
  8. [9]Dröge W Free radicals in the physiological control of cell function Physiological Reviews 2002 82 1 47 95 2-s2.0-0036086130 11773609
  9. [10]Lu S-P Lin Feng M-H Huang H-L Huang Y-C Tsou W-I Lai M-Z Reactive oxygen species promote raft formation in T lymphocytes Free Radical Biology & Medicine 2007 42 7 936 944 2-s2.0-33847684721 17349922
  10. [11]Atkins CM Sweatt JD Reactive oxygen species mediate activity-dependent neuron-glia signaling in output fibers of the hippocampus The Journal of Neuroscience 1999 19 17 7241 7248 2-s2.0-0033198188 10460230 PMC6782520
  11. [12]Hu D Serrano F Oury TD Klann E Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase The Journal of Neuroscience 2006 26 15 3933 3941 2-s2.0-33646101468 16611809 PMC6673899
  12. [13]Mehta SL Kumari S Mendelev N Li PA Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia BMC Neuroscience 2012 13, article 79 PMC3411431 22776356
  13. [14]Badjatia N Seres D Carpenter A Free fatty acids and delayed cerebral ischemia after subarachnoid hemorrhage Stroke 2012 43 3 691 696 2-s2.0-84857654580 22282893 PMC4198386
  14. [15]Chen G Jing CH Liu PP Ruan D Wang L Induction of autophagic cell death in the rat brain caused by iron The American Journal of the Medical Sciences 2013 345 5 369 374 23187302
  15. [16]McCracken E Valeriani V Simpson C Jover T McCulloch J Dewar D The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes Journal of Cerebral Blood Flow and Metabolism 2000 20 11 1529 1536 2-s2.0-0033756824 11083227
  16. [17]Cui J Holmes EH Greene TG Liu PK Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain FASEB Journal 2000 14 7 955 967 2-s2.0-0034014316 10783150 PMC2709847
  17. [19]Hansson MJ Månsson R Morota S Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition Free Radical Biology & Medicine 2008 45 3 284 294 2-s2.0-46449116985 18466779
  18. [20]Opii WO Nukala VN Sultana R Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury Journal of Neurotrauma 2007 24 5 772 789 2-s2.0-34249096439 17518533
  19. [21]Lemasters JJ Theruvath TP Zhong Z Nieminen A-L Mitochondrial calcium and the permeability transition in cell death Biochimica et Biophysica Acta 2009 1787 11 1395 1401 2-s2.0-68649095201 19576166 PMC2730424
  20. [22]Rasola A Sciacovelli M Pantic B Bernardi P Signal transduction to the permeability transition pore FEBS Letters 2010 584 10 1989 1996 2-s2.0-77952671613 20153328 PMC2866765
  21. [24]Tobe EH Mitochondrial dysfunction, oxidative stress, and major depressive disorder Neuropsychiatric Disease and Treatment 2013 9 567 573 23650447 PMC3640606
  22. [25]Tsaluchidu S Cocchi M Tonello L Puri BK Fatty acids and oxidative stress in psychiatric disorders BMC Psychiatry 2008 8 supplement 1, article S5 2-s2.0-46949102135 PMC2330073 18433515
  23. [26]Masood A Nadeem A Mustafa SJ O’Donnell JM Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice Journal of Pharmacology and Experimental Therapeutics 2008 326 2 369 379 2-s2.0-47949118698 18456873 PMC2913601
  24. [27]Arranz MJ de Leon J Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research Molecular Psychiatry 2007 12 8 707 747 2-s2.0-34547469943 17549063
  25. [28]Bouayed J Rammal H Younos C Soulimani R Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice European Journal of Pharmacology 2007 564 1–3 146 149 2-s2.0-34250787612 17395178
  26. [30]Marazziti D Baroni S Picchetti M Psychiatric disorders and mitochondrial dysfunctions European Review for Medical and Pharmacological Sciences 2012 16 2 270 275 2-s2.0-84859482117 22428481
  27. [33]Auerbach BD Osterweil EK Bear MF Mutations causing syndromic autism define an axis of synaptic pathophysiology Nature 2011 480 7375 63 68 2-s2.0-82555196668 22113615 PMC3228874
  28. [35]Dagda RK Cherra SJ III Kulich SM Tandon A Park D Chu CT Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission The Journal of Biological Chemistry 2009 284 20 13843 13855 2-s2.0-67649399288 19279012 PMC2679485
  29. [36]Boess FG Hendrix M van der Staay F-J Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance Neuropharmacology 2004 47 7 1081 1092 2-s2.0-8844220521 15555642
  30. [37]Werner C Raivich G Cowen M Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol European Journal of Neuroscience 2004 20 12 3498 3506 2-s2.0-10944220561 15610182
  31. [39]Rossignol DA Frye RE A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures Molecular Psychiatry 2012 17 4 389 401 2-s2.0-84859005372 22143005 PMC3317062
  32. [40]Gu F Chauhan V Kaur K Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism Translational Psychiatry 2013 3, article e299 PMC3784762 24002085
  33. [42]Kano S Colantuoni C Han F Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia Molecular Psychiatry 2012 18 7 740 742 22925834 PMC3582810
  34. [43]Kubera M Grygier B Wrona D Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice Journal of Neuroimmunology 2011 240-241 34 44 2-s2.0-83555176364 22030244
  35. [45]Wang X Lo EH Triggers and mediators of hemorrhagic transformation in cerebral ischemia Molecular Neurobiology 2003 28 3 229 244 2-s2.0-0742321910 14709787
  36. [46]Godínez-Rubí M Rojas-Mayorquín AE Ortuño-Sahagún D Nitric oxide donors as neuroprotective agents after an ischemic stroke-related inflammatory reaction Oxidative Medicine and Cellular Longevity 2013 2013 16 pages 297357 PMC3649699 23691263
  37. [47]Love S Oxidative stress in brain ischemia Brain Pathology 1999 9 1 119 131 2-s2.0-0032924640 9989455 PMC8098220
  38. [48]Lakhan SE Kirchgessner A Hofer M Inflammatory mechanisms in ischemic stroke: therapeutic approaches Journal of Translational Medicine 2009 7, article 97 2-s2.0-71049180369 PMC2780998 19919699
  39. [49]del Zoppo GJ Hallenbeck JM Advances in the vascular pathophysiology of ischemic stroke Thrombosis Research 2000 98 3 V73 V81 2-s2.0-0034192486 10812160
  40. [50]Harari OA Liao JK NF-κB and innate immunity in ischemic stroke Annals of the New York Academy of Sciences 2010 1207 32 40 2-s2.0-78149259667 20955423 PMC3807097
  41. [51]Nichols TC NF-κB and reperfusion injury Drug News & Perspectives 2004 17 2 99 104 2-s2.0-2342519916 15098063
  42. [52]Wei Z Chigurupati S Arumugam TV Jo D-G Li H Chan SL Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia Stroke 2011 42 9 2589 2594 2-s2.0-80052424570 21737799
  43. [53]Pradillo JM Fernández-López D García-Yébenes I Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning Journal of Neurochemistry 2009 109 1 287 294 2-s2.0-61849108779 19200341
  44. [54]Caso JR Pradillo JM Hurtado O Lorenzo P Moro MA Lizasoain I Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke Circulation 2007 115 12 1599 1608 2-s2.0-34247545017 17372179
  45. [55]Caso JR Pradillo JM Hurtado O Leza JC Moro MA Lizasoain I Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke Stroke 2008 39 4 1314 1320 2-s2.0-41149112041 18309167
  46. [57]Suzuki Y Hattori K Hamanaka J Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia Surface Science Reports 2012 2, article 896 PMC3508453 23193438
  47. [58]Jenner P Olanow CW The pathogenesis of cell death in Parkinson’s disease Neurology 2006 66 10, supplement 4 S24 S36 2-s2.0-33744977254 16717250
  48. [59]Hirsch EC Hunot S Neuroinflammation in Parkinson’s disease: a target for neuroprotection? The Lancet Neurology 2009 8 4 382 397 2-s2.0-62549133546 19296921
  49. [60]Gallagher DA Schapira AHV Etiopathogenesis and treatment of Parkinson’s disease Current Topics in Medicinal Chemistry 2009 9 10 860 868 2-s2.0-74249119940 19754402
  50. [61]Wu D-C Teismann P Tieu K NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 10 6145 6150 2-s2.0-0037947448 12721370 PMC156340
  51. [62]Blum-Degena D Müller T Kuhn W Gerlach M Przuntek H Riederer P Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients Neuroscience Letters 1995 202 1-2 17 20 2-s2.0-0029417080 8787820
  52. [65]Joglar B Rodriguez-Pallares J Rodriguez-Perez AI Rey P Guerra MJ Labandeira-Garcia JL The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease Journal of Neurochemistry 2009 109 2 656 669 2-s2.0-62649089147 19245663
  53. [66]Reynolds AD Stone DK Mosley RL Gendelman HE Nitrated α-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets Journal of Immunology 2009 182 7 4137 4149 2-s2.0-64249169415 PMC2659470 19299711
  54. [67]Markesbery WR Carney JM Oxidative alterations in Alzheimer’s disease Brain Pathology 1999 9 1 133 146 2-s2.0-0032902974 9989456 PMC8098393
  55. [68]Verri M Pastoris O Dossena M Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer’s disease International Journal of Immunopathology and Pharmacology 2012 25 2 345 353 22697066
  56. [69]Leuner K Müller WE Reichert AS From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease Molecular Neurobiology 2012 46 1 186 193 22833458
  57. [70]Younessi P Yoonessi A Advanced glycation end-products and their receptor-mediated roles: inflammation and oxidative stress Iranian Journal of Medical Sciences 2011 36 3 154 166 2-s2.0-80955135583 23358382 PMC3556769
  58. [71]Kalaria RN Harshbarger-Kelly M Cohen DL Premkumar DRD Molecular aspects of inflammatory and immune responses in Alzheimer’s disease Neurobiology of Aging 1996 17 5 687 693 2-s2.0-0030250614 8892341
  59. [72]Bornemann KD Wiederhold K-H Pauli C Aβ-induced inflammatory processes in microglia cells of APP23 transgenic mice American Journal of Pathology 2001 158 1 63 73 2-s2.0-0034746387 11141480 PMC1850262
  60. [73]Kitazawa M Yamasaki TR LaFerla FM Microglia as a potential bridge between the amyloid β-peptide and tau Annals of the New York Academy of Sciences 2004 1035 85 103 2-s2.0-14944367845 15681802
  61. [75]Zhang W Wang L-Z Yu J-T Chi Z-F Tan L Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer’s disease Journal of the Neurological Sciences 2012 315 1-2 67 71 2-s2.0-84858001196 22166855
  62. [76]Jin J-J Kim H-D Maxwell JA Li L Fukuchi K-I Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer’s disease Journal of Neuroinflammation 2008 5, article 23 2-s2.0-45849105153 PMC2430555 18510752
  63. [77]Tang S-C Lathia JD Selvaraj PK Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal Experimental Neurology 2008 213 1 114 121 2-s2.0-49349097868 18586243 PMC2597513
  64. [78]Balistreri CR Colonna-Romano G Lio D Candore G Caruso C TLR4 polymorphisms and ageing: Implications for the pathophysiology of age-related diseases Journal of Clinical Immunology 2009 29 4 406 415 2-s2.0-67651213832 19459036
  65. [79]Drechsel DA Estévez AG Barbeito L Beckman JS Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS Neurotoxicity Research 2012 22 4 251 264 2-s2.0-84859415239 22488161 PMC4145402
  66. [80]Gonsette RE Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity Journal of the Neurological Sciences 2008 274 1-2 48 53 2-s2.0-53049093018 18684473
  67. [81]Zeis T Probst A Steck AJ Stadelmann C Brück W Schaeren-Wiemers N Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis: molecular changes in MS periplaque white matter Brain Pathology 2009 19 3 459 466 2-s2.0-66949152122 19016740 PMC8094783
  68. [82]Fischer MT Sharma R Lim JL NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury Brain 2012 135 3 886 899 2-s2.0-84857538385 22366799 PMC3286337
  69. [83]Ratanayake U Quinn T Walker DW Dickinson H Cytokines and the neurodevelopmental basis of mental illness Frontiers in Neuroscience 2013 17 7, article 180 PMC3797953 24146637
  70. [84]Meyer U Nyffeler M Engler A The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology The Journal of Neuroscience 2006 26 18 4752 4762 2-s2.0-33646926705 16672647 PMC6674174
  71. [85]Gilmore JH Jarskog LF Vadlamudi S Lauder JM Prenatal infection and risk for schizophrenia: IL-1β, IL-6, and TNFα inhibit cortical neuron dendrite development Neuropsychopharmacology 2004 29 7 1221 1229 2-s2.0-2942683385 15085088
  72. [87]Potvin S Stip E Sepehry AA Gendron A Bah R Kouassi E Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review Biological Psychiatry 2008 63 8 801 808 2-s2.0-40949107708 18005941
  73. [88]Ashwood P Krakowiak P Hertz-Picciotto I Hansen R Pessah I Van de Water J Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome Brain, Behavior, and Immunity 2011 25 1 40 45 2-s2.0-78649322790 PMC2991432 20705131
  74. [90]Bennet L Gunn A Wintour-Coghlan M Owens J The fetal origins of adult mental illness Early Life Origins of Health and Disease (Advances in Experimental Medicine and Biology) 2006 New York, NY, USA Springer 204 211
  75. [91]Morgan JT Chana G Pardo CA Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism Biological Psychiatry 2010 68 4 368 376 2-s2.0-77955684004 20674603
  76. [92]Fredericks CA Drabant EM Edge MD Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions Brain, Behavior, and Immunity 2010 24 3 350 357 2-s2.0-77951622489 PMC2826575 19883751
  77. [93]Macchi F Homberg JR Calabrese F Altered inflammatory responsiveness in serotonin transporter mutant rats Journal of Neuroinflammation 2013 10, article 116 PMC3848577 24050835
  78. [94]Monji A Kato TA Mizoguchi Y Neuroinflammation in schizophrenia especially focused on the role of microglia Progress in Neuro-Psychopharmacology & Biological Psychiatry 2013 42 115 121 2-s2.0-84855590675 22192886
  79. [95]Liaury K Miyaoka T Tsumori T Morphological features of microglial cells in the hippocampal dentate gyrus of Gunn rat: a possible schizophrenia animal model Journal of Neuroinflammation 2012 9, article 56 2-s2.0-84858260810 PMC3334707 22424389
  80. [96]Post RM Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena Neuroscience and Biobehavioral Reviews 2007 31 6 858 873 2-s2.0-34548016732 17555817
  81. [97]Berk M Kapczinski F Andreazza AC Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors Neuroscience and Biobehavioral Reviews 2011 35 3 804 817 2-s2.0-78649938042 20934453
  82. [98]Iyengar RL Gandhi S Aneja A NSAIDs are associated with lower depression scores in patients with osteoarthritis American Journal of Medicine 2013 126 11 1017.e11 1017.e18 23993259
  83. [99]Harris JL Yeh HW Choi IY Altered neurochemical profile after traumatic brain injury: 1H-MRS biomarkers of pathological mechanisms Journal of Cerebral Blood Flow & Metabolism 2012 32 12 2122 2134 22892723 PMC3519407
  84. [100]Rossignol DA Frye RE A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures Molecular Psychiatry 2012 17 4 389 401 2-s2.0-84859005372 22143005 PMC3317062
  85. [101]Ming X Brimacombe M Chaaban J Zimmerman-Bier B Wagner GC Autism spectrum disorders: concurrent clinical disorders Journal of Child Neurology 2008 23 1 6 13 2-s2.0-37449005152 18056691
  86. [102]Frye RE Delatorre R Taylor H Redox metabolism abnormalities in autistic children associated with mitochondrial disease Translational Psychiatry 2013 3, article e273 PMC3693408 23778583
  87. [105]Jorgensen A Krogh J Miskowiak K Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy Journal of Affective Disorders 2013 149 1–3 355 362 23497793
  88. [106]Durand T De Felice C Signorini C F(2)-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome Biochimie 2013 95 86 90 23009927
  89. [107]Flatow J Buckley P Miller BJ Meta-analysis of oxidative stress in schizophrenia Biological Psychiatry 2013 74 6 400 409 23683390 PMC4018767
  90. [108]Bulut M Selek S Gergerlioglu HS Malondialdehyde levels in adult attention-deficit hyperactivity disorder Journal of Psychiatry and Neuroscience 2007 32 6 435 438 2-s2.0-37049037510 18043768 PMC2077350
  91. [109]Dwivedi Y Rizavi HS Conley RR Roberts RC Tamminga CA Pandey GN Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects Archives of General Psychiatry 2003 60 8 804 815 2-s2.0-0042154427 12912764
  92. [110]Sklar P Gabriel SB McInnis MG Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus Molecular Psychiatry 2002 7 6 579 593 2-s2.0-0036347948 12140781
  93. [111]Sen S Nesse RM Stoltenberg SF A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression Neuropsychopharmacology 2003 28 2 397 401 2-s2.0-0037310231 12589394
  94. [112]Kaufman J Yang B-Z Douglas-Palumberi H Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children Biological Psychiatry 2006 59 8 673 680 2-s2.0-33645337891 16458264
  95. [113]Chen Z-Y Jing D Bath KG Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior Science 2006 314 5796 140 143 2-s2.0-33749649795 17023662 PMC1880880
  96. [114]Sen S Duman R Sanacora G Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications Biological Psychiatry 2008 64 6 527 532 2-s2.0-49749101642 18571629 PMC2597158
  97. [115]Versace A Andreazza AC Young LT Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder Molecular Psychiatry 2013 PMC3640681 23358158
  98. [116]Najjar S Pearlman DM Hirsch S Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report Biological Psychiatry 2013 24075735
  99. [117]Kosenko EA Aliev G Tikhonova LA Li Y Poghosyan AC Kaminsky YG Antioxidant status and energy state of erythrocytes in Alzheimer dementia: probing for markers CNS & Neurological Disorders Drug Targets 2012 11 7 926 932 22998137
  100. [119]Bosetti F Brizzi F Barogi S Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer’s disease Neurobiology of Aging 2002 23 3 371 376 2-s2.0-0036231792 11959398
  101. [120]Mancuso M Filosto M Bosetti F Decreased platelet cytochrome c oxidase activity is accompanied by increased blood lactate concentration during exercise in patients with Alzheimer disease Experimental Neurology 2003 182 2 421 426 2-s2.0-0043166643 12895452
  102. [121]Leuner K Schulz K Schütt T Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes Molecular Neurobiology 2012 46 1 194 204 22821186
  103. [122]Puertas MC Martínez-Martos JM Cobo MP Carrera MP Mayas MD Ramírez-Expósito MJ Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia Experimental Gerontology 2012 47 8 625 630 22664577
  104. [123]Okun E Arumugam TV Tang S-C The organotellurium compound ammonium trichloro(dioxoethylene-0,0′) tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice Journal of Neurochemistry 2007 102 4 1232 1241 2-s2.0-34547404713 17542809
  105. [124]Nagotani S Hayashi T Sato K Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress Stroke 2005 36 3 670 672 2-s2.0-14844328997 15692108
  106. [125]Lee WC Wong HY Chai YY Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker? Biochemical and Biophysical Research Communications 2012 425 4 842 847 22898049
  107. [126]Selley ML (E)-4-Hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson’s disease Free Radical Biology & Medicine 1998 25 2 169 174 2-s2.0-0032527641 9667492
  108. [127]Ilic TV Jovanovic M Jovicic A Tomovic M Oxidative stress indicators are elevated in de novo Parkinson’s disease patients Functional Neurology 1999 14 3 141 147 2-s2.0-0032786731 10568214
  109. [128]Bulut M Selek S Bez Y Lipid peroxidation markers in adult attention deficit hyperactivity disorder: new findings for oxidative stress Psychiatry Research 2013 209 3 638 642 23680468
  110. [129]Akyol Ö Herken H Uz E The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients: the possible role of oxidant/antioxidant imbalance Progress in Neuro-Psychopharmacology & Biological Psychiatry 2002 26 5 995 1005 2-s2.0-0036592438 12369276
  111. [130]Ceylan M Sener S Bayraktar AC Kavutcu M Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010 34 8 1491 1494 2-s2.0-78649523256 20732373
  112. [131]Sanders LH Timothy Greenamyre J Oxidative damage to macromolecules in human Parkinson disease and the rotenone model Free Radical Biology & Medicine 2013 62 111 120 23328732 PMC3677955
  113. [132]Gulec M Ozkol H Selvi Y Oxidative stress in patients with primary insomnia Progress in Neuro-Psychopharmacology & Biological Psychiatry 2012 37 2 247 251 2-s2.0-84859591503 22401887
  114. [133]Kalra J Rajput AH Mantha SV Chaudhary AK Prasad K Oxygen free radical producing activity of polymorphonuclear leukocytes in patients with Parkinson’s disease Molecular and Cellular Biochemistry 1992 112 2 181 186 2-s2.0-0026728880 1322491
  115. [134]Cristalli DO Arnal N Marra FA de Alaniz MJT Marra CA Peripheral markers in neurodegenerative patients and their first-degree relatives Journal of the Neurological Sciences 2012 314 1-2 48 56 2-s2.0-84857037658 22113180
  116. [135]Kouti L Noroozian M Akhondzadeh S Nitric oxide and peroxynitrite serum levels in Parkinson's disease: correlation of oxidative stress and the severity of the disease European Review for Medical and Pharmacological Sciences 2013 17 7 964 970 23640445
  117. [137]Qin L Liu Y Hong JS Crews FT NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration Glia 2013 61 6 855 868 23536230 PMC3631289
  118. [138]Milani P Ambrosi G Gammoh O Blandini F Cereda C SOD1 and DJ-1 converge at Nrf2 pathway: a clue for antioxidant therapeutic potential in neurodegeneration Oxidative Medicine and Cellular Longevity 2013 2013 12 pages 836760 PMC3745953 23983902
  119. [139]Cheng MY Lee I-P Jin M An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy Translational Stroke Research 2011 2 1 92 100 2-s2.0-79951517175 21603078 PMC3097421
  120. [140]Li Y Paonessa JD Zhang Y Mechanism of chemical activation of Nrf2 PLoS One 2012 7 4 e35122 PMC3338841 22558124
  121. [141]Gan L Vargas MR Johnson DA Johnson JA Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model The Journal of Neuroscience 2012 32 49 17775 17787 23223297 PMC3539799
  122. [142]Son TG Kawamoto EM Yu QS Greig NH Mattson MP Camandola S Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway Biochemical and Biophysical Research Communications 2013 433 4 602 606 23537652 PMC3652233
  123. [143]Dinkova-Kostova AT Holtzclaw WD Cole RN Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proceedings of the National Academy of Sciences of the United States of America 2002 99 18 11908 11913 2-s2.0-0037015035 12193649 PMC129367
  124. [144]Hong F Freeman ML Liebler DC Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane Chemical Research in Toxicology 2005 18 12 1917 1926 2-s2.0-29644443964 16359182
  125. [145]Jiang H Tian X Guo Y Duan W Bu H Li C Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity Biological and Pharmaceutical Bulletin 2011 34 8 1194 1197 2-s2.0-80051500260 21804205
  126. [146]Kaidery NA Banerjee R Yang L Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease Antioxidants & Redox Signaling 2013 18 2 139 157 22746536 PMC3514006
  127. [147]L’Episcopo F Tirolo C Testa N Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in Parkinsonian mice via PI3K-Wnt/β-Catenin dysregulation The Journal of Neuroscience 2013 33 4 1462 1485 23345222 PMC3564519
  128. [148]Pérez-de-Puig I Martín A Gorina R de la Rosa X Martinez E Planas AM Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice Neuroscience 2013 243 22 32 23562577
  129. [149]Buga AM Scholz CJ Kumar S Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke PLoS One 2012 7 e50985 PMC3521001 23251410
  130. [150]Bousquet M Calon F Cicchetti F Impact of omega-3 fatty acids in Parkinson’s disease Ageing Research Reviews 2011 10 4 453 463 2-s2.0-80052340822 21414422
  131. [151]Joshi K Lad S Kale M Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD) Prostaglandins Leukotrienes and Essential Fatty Acids 2006 74 1 17 21 2-s2.0-28844450287 16314082
  132. [152]Richardson AJ Montgomery P The Oxford-Durham Study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder Pediatrics 2005 115 5 1360 1366 2-s2.0-20744445534 15867048
  133. [153]Kamat CD Gadal S Mhatre M Williamson KS Pye QN Hensley K Antioxidants in central nervous system diseases: preclinical promise and translational challenges Journal of Alzheimer’s Disease 2008 15 3 473 493 2-s2.0-57349180534 PMC2669703 18997301
  134. [155]Høyer-Hansen M Nordbrandt SPS Jäättelä M Autophagy as a basis for the health-promoting effects of vitamin D Trends in Molecular Medicine 2010 16 7 295 302 20488750
  135. [156]Tuohimaa P Keisala T Minasyan A Cachat J Kalueff A Vitamin D, nervous system and aging Psychoneuroendocrinology 2009 34 1 S278 S286 2-s2.0-71249144773 19660871
  136. [157]Kaundal RK Sharma SS Peroxisome proliferator-activated receptor γ agonists as neuroprotective agents Drug News & Perspectives 2010 23 4 241 256 2-s2.0-77954589341 20520853
  137. [158]Polvani S Tarocchi M Galli A PPAR and oxidative stress: Con(β) catenating NRF2 and FOXO PPAR Research 2012 2012 15 pages 2-s2.0-84859762514 641087 PMC3317010 22481913
  138. [159]Haraguchi T Iwasaki K Takasaki K Telmisartan, a partial agonist of peroxisome proliferator-activated receptor γ, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia Brain Research 2010 1353 1 125 132 2-s2.0-77956393248 20637184
  139. [160]Washida K Ihara M Nishio K Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion Stroke 2010 41 8 1798 1806 2-s2.0-77955171963 20595663
  140. [161]Kishi T Hirooka Y Sunagawa K Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats Journal of Cardiology 2012 60 6 489 494 22948091
  141. [162]Xu F Li J Ni W Shen YW Zhang XP Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury PLoS One 2013 8 1 e55080 PMC3555818 23372817
  142. [163]Tureyen K Kapadia R Bowen KK Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents Journal of Neurochemistry 2007 101 1 41 56 2-s2.0-33947204503 17394460
  143. [164]Park S-W Yi J-H Miranpuri G Thiazolidinedione class of peroxisome proliferator-activated receptor γ agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats Journal of Pharmacology and Experimental Therapeutics 2007 320 3 1002 1012 2-s2.0-33847093475 17167171
  144. [165]Pereira MP Hurtado O Cárdenas A The nonthiazolidinedione PPARγ agonist L-796,449 is neuroprotective in experimental stroke Journal of Neuropathology and Experimental Neurology 2005 64 9 797 805 2-s2.0-24644503529 16141790
  145. [166]Chungpaibulpatana J Sumpatanarax T Thadakul N Chantharatreerat C Konkaew M Aroonlimsawas M Hyperbaric oxygen therapy in Thai autistic children Journal of the Medical Association of Thailand 2008 91 8 1232 1238 2-s2.0-50949097997 18788696
  146. [167]Rossignol DA Rossignol LW Hyperbaric oxygen therapy may improve symptoms in autistic children Medical Hypotheses 2006 67 2 216 228 2-s2.0-33744739160 16554123
  147. [168]Joseph C Buga AM Vintilescu R Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia Journal of Cerebral Blood Flow & Metabolism 2012 32 8 1632 1642 22617647 PMC3421103
  148. [169]Ji Q Hui K Zhang L Sun X Li W Duan M The effect of hydrogen-rich saline on the brain of rats with transient ischemia Journal of Surgical Research 2011 168 1 e95 e101 2-s2.0-79955607676 21435662
  149. [170]Li J Dong Y Chen H Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines Brain Research 2012 1486 1 103 111 23010312
  150. [171]Khairova R Pawar R Salvadore G Effects of lithium on oxidative stress parameters in healthy subjects Molecular Medicine Reports 2012 5 3 680 682 2-s2.0-84856243953 22200861 PMC3289682
  151. [172]Chuang DM Wang Z Chiu CT GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke Frontiers in Molecular Neuroscience 2011 4, article 15 PMC3152742 21886605
  152. [173]Pignitter M Gorren ACF Nedeianu S Schmidt K Mayer B Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling Free Radical Biology & Medicine 2006 41 3 455 463 2-s2.0-33745907851 16843826
  153. [174]Talarowska M Gałecki P Maes M Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder Neuroscience Letters 2012 510 2 127 131 2-s2.0-84856772767 22273980
  154. [175]Yoshitomi T Hirayama A Nagasaki Y The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles Biomaterials 2011 32 31 8021 8028 2-s2.0-80051815640 21816462
  155. [176]Michel TM Sheldrick AJ Camara S Grnblatt E Schneider F Riederer P Alteration of the pro-oxidant xanthine oxidase (XO) in the thalamus and occipital cortex of patients with schizophrenia World Journal of Biological Psychiatry 2011 12 8 588 597 2-s2.0-82955246786 21073395
  156. [177]Hu X Zhou H Zhang D Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation Journal of NeuroImmune Pharmacology 2012 7 1 187 201 21870076 PMC3633602
  157. [178]Pandya CD Howell KR Pillai A Antioxidants as potential therapeutics for neuropsychiatric disorders Progress in Neuropsychopharmacology & Biological Psychiatry 2013 46 214 223 PMC3615047 23123357
  158. [179]Dodd S Maes M Anderson G Dean OM Moylan S Berk M Putative neuroprotective agents in neuropsychiatric disorders Progress in Neuro-Psychopharmacology & Biological Psychiatry 2013 42 135 145 23178231
  159. [180]Grillo RW Ottoni GL Leke R Souza DO Portela LV Lara DR Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics Journal of Psychiatric Research 2007 41 1-2 31 35 2-s2.0-33750735357 16546213
  160. [181]Pedrini M Chendo I Grande I Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlation Neuroscience Letters 2011 491 3 207 210 2-s2.0-79951773515 21256922
  161. [182]Lim C-M Kim S-W Park J-Y Kim C Yoon SH Lee J-K Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect Journal of Neuroscience Research 2009 87 4 1037 1045 2-s2.0-63849303038 18855941
  162. [183]Wehner NG Skov M Shopp G Rocca MS Clarke J Effects of natalizumab, an α4 integrin inhibitor, on fertility in male and female guinea pigs Birth Defects Research B 2009 86 2 108 116 2-s2.0-65549091168 19283862

Cited by

Sorted by citations

Authors
Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M.
Affiliations
  • Department of Psychiatry, Rostock University Medical School, Gehlsheimer Straße 20, 18147 Rostock, Germany
  • University of Medicine and Pharmacy of Craiova (RO)
  • Iowa State University (US)
  • Stanford Medicine (US)
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-14
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2013/963520
PMC
PMC3871919
OpenAlex
W2171555296
Cited by
427
References
21
Citations by year
2026: 16 · 2025: 30 · 2024: 52 · 2023: 38 · 2022: 48 · 2021: 57 · 2020: 48 · 2019: 30 · 2018: 26 · 2017: 26 · 2016: 26 · 2015: 16 · 2014: 11
FWCI
1.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (80)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords
reactive oxygen species, oxidative stress, neuropsychiatric disorders, major depressive disorder, schizophrenia, attention deficit hyperactivity disorder, neuroinflammation, neuroprotection, Nrf2, antioxidant therapy, lipid peroxidation, nanoparticle drug delivery, brain aging, antioxidant drugs
MeSH terms
Animals, Brain Diseases, Humans, Mitochondria, Biomarkers, Reactive Oxygen Species, Oxidative Stress, PPAR gamma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review