The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response
Abstract
Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses of the clinical and immunological parameters throughout the disease course were analyzed in either the “recovered” or the “chronic” groups to identify prognostic markers of arthritis-like pathology after CHIKV disease. We found that the chronic group consisted mainly of more elderly patients (>60 y) and with much higher viral loads (up to 1010 viruses per milliliter of blood) during the acute phase. Remarkably, a rapid innate immune antiviral response was demonstrated by robust dendritic/NK/CD4/CD8 cell activation and accompanied by a rather weak Th1/Th2 cytokine response in both groups. Interestingly, the antiviral immune response witnessed by high levels of IFN-α mRNA in PBMCs and circulating IL-12 persisted for months only in the chronic group. CHIKV (RNA and proteins) was found in perivascular synovial macrophages in one chronic patient 18 mo postinfection surrounded by infiltrating NK and T cells (CD4++ but rare cytotoxic CD8). Fibroblast hyperplasia, strong angiogenesis, tissue lesions given the high levels of matrix metalloproteinase 2, and acute cell death [high cleaved poly(ADP-ribose) polymerase staining] were observed in the injured synovial tissue. These observed cellular and molecular events may contribute to chronic arthralgia/arthritis targeted by methotrexate used empirically for effective treatment but with immunosuppressive function in a context of viral persistence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Blacklow, N. R., Gorbach, S. L., & Bartlett, J. G. (1992) · Cited by 2,753
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C., & Haslett, C. (2002) · Nature Reviews Immunology · doi:10.1038/nri957 · Cited by 1,574
Infection with chikungunya virus in Italy: an outbreak in a temperate region
Rezza, G., Nicoletti, L., Angelini, R., Romi, R., Finarelli, A., Panning, M., Cordioli, P., Fortuna, C., Boros, S., Magurano, F., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61779-6 · Cited by 1,527
Chikungunya, an epidemic arbovirosis
Pialoux, G., Gaüzère, B.-A., Jauréguiberry, S., & Strobel, M. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70107-x · Cited by 1,129
Viral evasion and subversion of pattern-recognition receptor signalling
Bowie, A. G., & Unterholzner, L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2436 · Cited by 746
Couderc, T., Chrétien, F., Schilte, C., Disson, O., Brigitte, M., Guivel-Benhassine, F., Touret, Y., Barau, G., Cayet, N., Schuffenecker, I., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040029 · Cited by 620
ECONOMOPOULOU, A., DOMINGUEZ, M., HELYNCK, B., SISSOKO, D., WICHMANN, O., QUENEL, P., GERMONNEAU, P., & QUATRESOUS, I. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808001167 · Cited by 570
Borgherini, G., Poubeau, P., Staikowsky, F., Lory, M., Moullec, N. L., Becquart, J. P., Wengling, C., Michault, A., & Paganin, F. (2007) · Clinical Infectious Diseases · doi:10.1086/517537 · Cited by 522
Gérardin, P., Barau, G., Michault, A., Bintner, M., Randrianaivo, H., Choker, G., Lenglet, Y., Touret, Y., Bouveret, A., Grivard, P., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050060 · Cited by 521
Ross River Virus Transmission, Infection, and Disease: a Cross-Disciplinary Review
Harley, D., Sleigh, A., & Ritchie, S. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.909-932.2001 · Cited by 468
Cited by
A Mouse Model of Chikungunya Virus–Induced Musculoskeletal Inflammatory Disease
Morrison, T. E., Oko, L., Montgomery, S. A., Whitmore, A. C., Lotstein, A. R., Gunn, B. M., Elmore, S. A., & Heise, M. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.018 · Cited by 290
A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development
de Lima Cavalcanti, T. Y. V., Pereira, M. R., de Paula, S. O., & Franca, R. F. D. O. (2022) · Viruses · doi:10.3390/v14050969 · Cited by 259
Chang, L.-J., Dowd, K. A., Mendoza, F. H., Saunders, J. G., Sitar, S., Plummer, S. H., Yamshchikov, G., Sarwar, U. N., Hu, Z., Enama, M. E., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61185-5 · Cited by 257
Assay optimization for molecular detection of Zika virus
Corman, V., Rasche, A., Baronti, C., Aldabbagh, S., Cadar, D., Reusken, C., Pas, S., Goorhuis, A., Schinkel, J., Molenkamp, R., et al. (2016) · Bulletin of the World Health Organization · doi:10.2471/blt.16.175950 · Cited by 166
Persistent Joint Pain Following Arthropod Virus Infections
Suchowiecki, K., Reid, S. P., Simon, G. L., Firestein, G. S., & Chang, A. (2021) · Current Rheumatology Reports · doi:10.1007/s11926-021-00987-y · Cited by 37
Metadata
- Authors
- Hoarau, J.-J., Jaffar Bandjee, M.-C., Krejbich Trotot, P., Das, T., Li-Pat-Yuen, G., Dassa, B., Denizot, M., Guichard, E., Ribera, A., Henni, T., Tallet, F., Moiton, M. P., Gauzère, B. A., Bruniquet, S., Jaffar Bandjee, Z., Morbidelli, P., Martigny, G., Jolivet, M., Gay, F., Grandadam, M., Tolou, H., Vieillard, V., Debré, P., Autran, B., & Gasque, P.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05
- Volume
- 184
- Issue
- 10
- Pages
- 5914-5927
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2136631930
- Cited by
- 640
- References
- 42
- FWCI
- 25.94
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response. https://app.cochat.ai/papers/10.4049/jimmunol.0900255
- The paper
- Hoarau, J.-J., Jaffar Bandjee, M.-C., Krejbich Trotot, P., Das, T., Li-Pat-Yuen, G., Dassa, B., Denizot, M., Guichard, E., Ribera, A., Henni, T., Tallet, F., Moiton, M. P., Gauzère, B. A., Bruniquet, S., Jaffar Bandjee, Z., Morbidelli, P., Martigny, G., Jolivet, M., Gay, F., . . . Gasque, P. (2010). Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0900255
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
