Cited by 101Immune Response and InflammationImmune responses and vaccinationsInflammasome and immune disorders

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Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production

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Mielke, Lisa A, Elkins, Karen L, Wei, Lai, Starr, Robyn, Tsichlis, Philip N, O'Shea, John J, Watford, Wendy T·2009·The Journal of Immunology

DOI 10.4049/jimmunol.0901336PMC PMC2946069

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Abstract

Tumor progression locus 2 (Tpl2, also known as Map3k8 and Cot) is a serine-threonine kinase critical in innate immunity, linking toll-like receptors (TLRs) to TNF production through its activation of ERK. Tpl2−/− macrophages have abrogated TNF production but overproduce IL-12 in response to TLR ligands. Despite enhanced IL-12 production, Tpl2−/− T cells have impaired IFN-γ production. Therefore, the role of Tpl2 in a bona fide bacterial infection where all of these cytokines are important in host defense is unclear. To address this issue, we infected Tpl2−/− mice with the model pathogen Listeria monocytogenes. We found that Tpl2−/− mice infected i.v. with L. monocytogenes had increased pathogen burdens compared with wild-type mice and rapidly succumbed to infection. Enhanced susceptibility correlated with impaired signaling through TLR2 and nucleotide-binding oligomerization domain 2, two receptors previously shown to mediate Listeria recognition. Surprisingly, TNF production in response to infection was not significantly impaired, even though Tpl2 has been implicated in the regulation of TNF. We found that the role of Tpl2 has cell-type specific effects in regulating TNF and transduces signals from some, but not all, pattern recognition receptors (PRR). In contrast to the cell-type- and receptor-specific regulation of TNF, we found that Tpl2 is essential for IL-1β production from both macrophages and dendritic cells. These studies implicate Tpl2 as an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns to induce TNF and IL-1β production and optimal host defense.

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Authors: Mielke, L. A., Elkins, K. L., Wei, L., Starr, R., Tsichlis, P. N., O'Shea, J. J., & Watford, W. T.
Affiliations: National Institutes of Health (US)
Center for Biologics Evaluation and Research (US)
St Vincents Institute of Medical Research (AU)
Tufts Medical Center (US)
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda , MD 20892
Corresponding author: Wei, Lai
ORCID: Mielke, Lisa A
Elkins, Karen L
Wei, Lai
Tsichlis, Philip N
Watford, Wendy T
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2009-12
Volume: 183
Issue: 12
Pages: 7984-7993
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.0901336
PMC: PMC2946069
OpenAlex: W2130201289
Cited by: 98
References: 62
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 13 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 7 · 2012: 8
FWCI: 2.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Office of Science
National Cancer Institute (R01CA095431)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (#1 K22 AR53953-01, Z01AR041132, ZIAAR041161, Z01AR041159, K22AR053953, Z01AR041160, ZIAAR041167, ZIAAR041106, Z01AR041106, Z01AR041167, ZIAAR041159)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: TPL2, MAP3K8, Listeria monocytogenes, IL-1β, TNF production, TLR2, NOD2, pattern recognition receptors, innate immunity, macrophages, dendritic cells, interferon-gamma, bacterial infection susceptibility, damage-associated molecular patterns
MeSH terms: Animals, Cells, Cultured, Female, Gene Expression Regulation, Immunity, Innate, Listeriosis, Listeria monocytogenes, Male, Mice, Inbred C57BL, Proto-Oncogene Proteins, Transduction, Genetic, Signal Transduction, Mice, Knockout, MAP Kinase Kinase Kinases, Mice, Interleukin-1beta

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Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1β Production

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