SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells

Brooks, Robert, Fuhler, Gwenny M, Iyer, Sonia, Smith, Michelle J, Park, Mi-Young, Paraiso, Kim H T, Engelman, Robert W, Kerr, William G·2010·The Journal of Immunology
DOI 10.4049/jimmunol.0902844

Cited by (142)

Items 101–142 of 142

  1. AS1949490, an inhibitor of 5′-lipid phosphatase SHIP2, promotes protein kinase C-dependent stabilization of brain-derived neurotrophic factor mRNA in cultured cortical neurons
    Hiroshi Tsuneki, Hitomi Yoshida, Kentaro Okamoto, Misako Yamaguchi, Kosuke Endo, Ayumi Nakano, Masaaki Tsuda, Naoki Toyooka, Tsutomu Wada, Toshiyasu Sasaoka · 2019 · European Journal of Pharmacology
  2. Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival
    Simar Pal Singh, Marjolein J. W. de Bruijn, Catarina Gago de Graça, Odilia B. J. Corneth, Jasper Rip, Ralph Stadhouders, Ruud W. J. Meijers, Stéphane Schurmans, William Garrow Kerr, Johanna ter Burg et al. · 2019 · The Journal of Immunology
  3. Nuclear phosphoinositide signaling in cell biology and disease
    Yanan Sun, Fengting Liu, Chunbo Chen, Jichao Sun, Mo Chen · 2026 · Developmental Cell
  4. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases
    Patrick A. H. Ehm, Michael Linnebacher, Andreas Block, Christoph Rehbach, Manfred Jücker · 2023 · Cellular Signalling
  5. Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells
    Pernille Rasmussen, Edzard Spillner, Hans Jürgen Hoffmann · 2019 · Immunology Letters
  6. N1-Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents
    Sandra Fernandes, Shea T. Meyer, Jigisha P. Shah, Arijit A. Adhikari, William Garrow Kerr, John D. Chisholm · 2022 · Molecules
  7. SHIP1 Controls Internal Platelet Contraction and αIIbβ3 Integrin Dynamics in Early Platelet Activation
    Sonia Séverin, Alessandra Consonni, Gaëtan Chicanne, Sophie Allart, Bernard Payrastre, Marie‐Pierre Gratacap · 2023 · International Journal of Molecular Sciences
  8. INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia
    Terzioglu, Gizem, Karp, Emma S., Heuer, Sarah E., Chadarevian, Jean Paul, Ahsan, Fasih M., Haage, Verena C., Davtyan, Hayk, Fogo, Garrett M., Curle, Annabel J., Ashour, Nancy et al. · 2025
  9. Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway
    Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen M. Rennert, Boxian Huang, Hoi‐Hung Cheung · 2025 · Cell & Bioscience
  10. Discovery and Characterization of a Selective Inhibitor of Synaptojanin1 5-Phosphatase Activity
    Ella Martin, Danaë Giakoumakis, Jone Paesmans, Nicolò Bisi, Andrzej Drozdzecki, Dominique Audenaert, Jurgen Haustraete, Patrik Verstreken, Christian Galicia, Steven Ballet et al. · 2025 · ACS Pharmacology & Translational Science
  11. Two SHIP s passing in the middle of the immune system
    Seth Joel Corey, Hrishikesh Mehta, Paul L. Stein · 2012 · European Journal of Immunology
  12. Synthetic studies on the indane SHIP1 agonist AQX-1125
    Otto M. Dungan, Shawn Dormann, Sandra Fernandes, Brian C. Duffy, Daniel Effiong, William Garrow Kerr, John D. Chisholm · 2022 · Organic & Biomolecular Chemistry
  13. Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes
    Jamil Mahmud, Brittany W. Geiler, Juthi Biswas, Michael J. Miller, Julia E. Myers, Stephen M. Matthews, Amanda B. Wass, Christine M. O’Connor, Gary C. T. Chan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  14. SHIP‐1 Differentially Regulates IgE‐Induced IL‐10 and Antiviral Responses in Human Monocytes
    Siva Kumar Solleti, Bailey E. Matthews, Jingyi Wu, Regina K. Rowe · 2024 · European Journal of Immunology
  15. Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer’s Disease Models
    Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach, Daniel E. Beck, Isaac Caballero-Floran, Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N. Faulkner et al. · 2026 · Journal of Medicinal Chemistry
  16. SHIP blocks (MDP + LPS)-induced synergy in macrophages independent of catalytic activity
    Yvonne C. F. Pang, Susan C. Menzies, Laura M. Sly · 2026 · Journal of Leukocyte Biology
  17. Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)
    Angela Pacherille, Dennis R. Viernes, Chiara Pedicone, Sandra Fernandes, Otto M. Dungan, Shawn Dormann, Daniel R. Wallach, Raki Sudan, Robbie Brooks, Christopher M. Russo et al. · 2025 · ChemMedChem
  18. Chemical Inhibitors of Phosphatidylinositol Transfer Proteins Enable Highly Selective Interference With Specific Pathways of Phosphoinositide Signaling in Cells
    Aaron H. Nile · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  19. Nanotechnology for Diagnosis, Imaging, and Treatment of Head and Neck Cancer
    Mehdi Ebrahimi · 2021 · Springer eBooks
  20. Myeloid Specific Ablation of SHIP1 Boosts ex vivo Expansion and Regulatory Function of Myeloid-Derived Suppressor Cells in Inflammatory Arthritis
    Eui Young So, Moon Jung Choi, Young Eun Lee, Bedia Akosman, Euy-Myoung Jeong, Anthony M. Reginato, Olin D. Liang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  21. The Role of Tumor Suppressors, SHIP and Rb, in Immune Suppressive Cells
    C González Ruiz, Michelle Marie · 2012
  22. Yet another case of haemochromatosis?
    Andrew J. Fowell, Adrian Calvin Bateman, W.J.H. Griffiths, Kathryn L. Nash · 2010 · Gut
  23. A Novel Therapeutic Approach in Breast and Hematopoietic Cancers: Inhibition of SH2-Domain Containing Inositol 5' Phosphatase (SHIP)
    Amamda Balch · 2013 · Syracuse University Libraries (Syracuse University)
  24. Role of SHIP-1 phosphatase in trained immunity modulation
    Paula Sanz-Leal · 2018
  25. Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegeneration
    Ana Maria Silva, Anna Cederbalk, Daniel V. Ebner, Elena Di Daniel · 2020 · Royal Society of Chemistry eBooks
  26. SHIP
    Matthew D. Blunt, Stephen Geoffrey Ward · 2017 · Springer eBooks
  27. SH2 Domain-containing Inositol Phosphatase-1 (SHIP)
    Matthew D. Blunt, Stephen Geoffrey Ward · 2014 · Springer eBooks
  28. SHIP
    Matthew D. Blunt, Stephen Geoffrey Ward · 2012 · Springer eBooks
  29. Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1
    Grace L. Waddell, Emma E. Drew, Henry P. Rupp, Scott D. Hansen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Untersuchung der Rolle von BRD7 und DOT1L im Prä-B-Zellrezeptor-Signalweg
    Jessica Lena Peter · 2023
  31. Primeira etapa da disseminação hematogênica de células de câncer de colorretal
    Alessandra Valéria de Sousa Faria · 2020
  32. ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease
    Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  33. SHIPi improves hematologic recovery after chemotherapy
    Sandra Fernandes, Chiara Pedicone, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Carlos del Fresno, David Sancho, Bonnie B. Toms, Brian Walker et al. · 2025 · Molecular Medicine
  34. An overview of small molecule approaches in cancer immunotherapy
    John D. Chisholm, William Garrow Kerr · 2025 · Elsevier eBooks
  35. SHIP-1 Modulation in Experimental Allergic Conjunctivitis: Impact on CD4 + T Cell Migration
    Fangli Fan, Yifeng Wu, Danyan Tang, Jun Zuo, Yujie Shu, Zhen Deng, Kaijun Wang · 2026 · Current Eye Research
  36. Insulin-Regulated Amino Peptidase (IRAP) controls FcR-mediated signaling and inflammatory responses
    Manuela Bratti · 2021
  37. Epigenetic regulation of INPP5D and its downstream molecular network in autoimmune pancreatitis
    Takeshi Uehara, Mai Iwaya, Shiho Asaka, Tomoyuki Nakajima, Shotaro Komamura, Hiroshi Sawaguchi, Shunsuke Imamura, Akira Nakamura, Shinsuke Sugenoya, Akira Shimizu et al. · 2026 · BMC Gastroenterology
  38. Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis
    Nelson V. Simwela, Luana Johnston, Christopher M. Sassetti, David G. Russell · 2026 · PLoS Pathogens
  39. SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC ‐derived model
    Kim St. Martin, Juliane Obst, Shania Ibarra, Emma J. Murphy, Katerina Gospodinova, Emma Mead · 2026 · FEBS Journal
  40. Decoding PIP signaling: structure and catalytic mechanisms of the human phosphoinositide 5-phosphatases
    Ella Martin, Wim Versées · 2026 · Critical Reviews in Biochemistry and Molecular Biology
  41. BindingDB Entry 50018630: If small molecules immunotherapy comes, can the prime be far behind?
    BindingDB · 2024 · UC San Diego
  42. BindingDB Entry 50015413: Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.
    BindingDB · 2023 · UC San Diego