The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation
Open accessAbstract
The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation. Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds. Donor corneas (C57BL/6) were transplanted into uninflamed or inflamed avascular, prehemvascularized only or prehemvascularized and prelymphvascularized recipient murine eyes (BALB/C). Selective inhibition of lymphangiogenesis was achieved using antivascular endothelial growth factor receptor 3 Abs and anti-integrin α5 small molecules. Grafts placed into only prehemvascularized recipient beds had a similarly good graft survival compared with grafts placed into completely avascular, normal recipients, whereas the pre-existence of lymphatic vessels significantly deteriorated corneal graft survival (p < 0.05). Lymphatic vessels seem to contribute significantly to graft rejection after (corneal) transplantation. That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cursiefen, C., Chen, L., Borges, L. P., Jackson, D. G., Cao, J., Radziejewski, C. H., D'Amore, P. A., Dana, M. R., Wiegand, S. J., & Streilein, J. W. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420465 · Cited by 1,059
Self-citationBlocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., et al. (2008) · Nature · doi:10.1038/nature07083 · Cited by 813
Maguire, M. G., Stark, W. J., Gottsch, J. D., Stulting, R. D., Sugar, A., Fink, N. E., & Schwartz, A. (1994) · Ophthalmology · doi:10.1016/s0161-6420(94)31138-9 · Cited by 466
Organ transplantation—how much of the promise has been realized?
Lechler, R. I., Sykes, M., Thomson, A. W., & Turka, L. A. (2005) · Nature Medicine · doi:10.1038/nm1251 · Cited by 390
Kerjaschki, D., Huttary, N., Raab, I., Regele, H., Bojarski-Nagy, K., Bartel, G., Kröber, S. M., Greinix, H., Rosenmaier, A., Karlhofer, F., et al. (2006) · Nature Medicine · doi:10.1038/nm1340 · Cited by 362
Cursiefen, C., Cao, J., Chen, L., Liu, Y., Maruyama, K., Jackson, D., Kruse, F. E., Wiegand, S. J., Dana, M. R., & Streilein, J. W. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-1380 · Cited by 329
Self-citationSONODA, Y., & STREILEIN, J. W. (1992) · Transplantation · doi:10.1097/00007890-199210000-00026 · Cited by 297
Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts
Sonoda, Y., & Streilein, J. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.5.1727 · Cited by 150
Lymphatic Neoangiogenesis in Human Renal Allografts: Results from Sequential Protocol Biopsies
Stuht, S., Gwinner, W., Franz, I., Schwarz, A., Jonigk, D. D., Kreipe, H. H., Kerjaschki, D., Haller, H. G., & Mengel, M. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01638.x · Cited by 114
Sano, Y., Ksander, B. R., & Streilein, J. W. (1995) · PubMed · Cited by 112
Cited by
The Pivotal Role of Vascularization in Tissue Engineering
Auger, F. A., Gibot, L., & Lacroix, D. (2013) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071812-152428 · Cited by 334
Hos, D., Matthaei, M., Bock, F., Maruyama, K., Notara, M., Clahsen, T., Hou, Y., Le, V. N. H., Salabarria, A.-C., Horstmann, J., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.001 · Cited by 303
Self-citationLymphatic function and immune regulation in health and disease
Liao, S., & Padera, T. P. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2013.0012 · Cited by 122
Metadata
- Authors
- Dietrich, T., Bock, F., Yuen, D., Hos, D., Bachmann, B. O., Zahn, G., Wiegand, S., Chen, L., & Cursiefen, C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-27
- Volume
- 184
- Issue
- 2
- Pages
- 535-539
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1518877530
- Cited by
- 292
- References
- 17
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation. https://app.cochat.ai/papers/10.4049/jimmunol.0903180
- The paper
- Dietrich, T., Bock, F., Yuen, D., Hos, D., Bachmann, B. O., Zahn, G., Wiegand, S., Chen, L., & Cursiefen, C. (2010). Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0903180
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
