The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
IL-22 Induces an Acute-Phase Response
Open accessAbstract
IL-22 is made by a unique set of innate and adaptive immune cells, including the recently identified noncytolytic NK, lymphoid tissue-inducer, Th17, and Th22 cells. The direct effects of IL-22 are restricted to nonhematopoietic cells, its receptor expressed on the surface of only epithelial cells and some fibroblasts in various organs, including parenchymal tissue of the gut, lung, skin, and liver. Despite this cellular restriction on IL-22 activity, we demonstrate that IL-22 induces effects on systemic biochemical, cellular, and physiological parameters. By utilizing adenoviral-mediated delivery of IL-22 and systemic administration of IL-22 protein, we observed that IL-22 modulates factors involved in coagulation, including fibrinogen levels and platelet numbers, and cellular constituents of blood, such as neutrophil and RBC counts. Furthermore, we observed that IL-22 induces thymic atrophy, body weight loss, and renal proximal tubule metabolic activity. These cellular and physiological parameters are indicative of a systemic inflammatory state. We observed that IL-22 induces biochemical changes in the liver including induction of fibrinogen, CXCL1, and serum amyloid A that likely contribute to the reported cellular and physiological effects of IL-22. Based on these findings, we propose that downstream of its expression and impact in local tissue inflammation, circulating IL-22 can further induce changes in systemic physiology that is indicative of an acute-phase response.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
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Self-citationProduction of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079
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Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
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Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A
Cheng, N., He, R., Tian, J., Ye, P. P., & Ye, R. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.22 · Cited by 284
IL-22 is involved in liver regeneration after hepatectomy
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Cited by
Sonnenberg, G. F., Fouser, L. A., & Artis, D. (2011) · Nature Immunology · doi:10.1038/ni.2025 · Cited by 1,044
Self-citationHepatocytes: a key cell type for innate immunity
Zhou, Z., Xu, M.-J., & Gao, B. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.97 · Cited by 472
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 470
Cytokines IL-17 and IL-22 in the host response to infection
Valeri, M., & Raffatellu, M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw111 · Cited by 202
Acute-phase protein synthesis: a key feature of innate immune functions of the liver
Ehlting, C., Wolf, S. D., & Bode, J. G. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0209 · Cited by 115
Metadata
- Authors
- Liang, S. C., Nickerson-Nutter, C., Pittman, D. D., Carrier, Y., Goodwin, D. G., Shields, K. M., Lambert, A.-J., Schelling, S. H., Medley, Q. G., Ma, H.-L., Collins, M., Dunussi-Joannopoulos, K., & Fouser, L. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-01
- Volume
- 185
- Issue
- 9
- Pages
- 5531-5538
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2108270917
- Cited by
- 171
- References
- 8
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liang, S. C., Nickerson-Nutter, C., Pittman, D. D., Carrier, Y., Goodwin, D. G., Shields, K. M., Lambert, A.-J., Schelling, S. H., Medley, Q. G., Ma, H.-L., Collins, M., Dunussi-Joannopoulos, K., & Fouser, L. A. (2010). IL-22 Induces an Acute-Phase Response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0904091
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