Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Abstract
Interleukin 22 (IL-22) is a cytokine produced by the T(H)-17 lineage of helper T cells and NK-22 subset of natural killer cells that acts on epithelial cells and keratinocytes and has been linked to skin homeostasis and inflammation. Here we characterize a population of human skin-homing memory CD4(+) T cells that expressed the chemokine receptors CCR10, CCR6 and CCR4 and produced IL-22 but neither IL-17 nor interferon-gamma (IFN-gamma). Clones isolated from this population produced IL-22 only and had low or undetectable expression of the T(H)-17 and T helper type 1 (T(H)1) transcription factors RORgammat and T-bet. The differentiation of T cells producing only IL-22 was efficiently induced in naive T cells by plasmacytoid dendritic cells in an IL-6- and tumor necrosis factor-dependent way. Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology.
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Th17 and Th22 subsets are pivotal to tackle extracellular pathogens, such as extracellular bacteria and fungi, and they both lack CXCR3 and express CCR6 and CCR4.
“Th17 and Th22 subsets are pivotal to tackle extracellular pathogens, such as extracellular bacteria and fungi, and they both lack CXCR3 and express CCR6 and CCR4 [152-154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
Th17 can be distinguished by expression of killer-cell lectin-like receptor CD161 (KLRB1), while Th22 expresses the skin-homing receptor CCR10.
“However, Th17 can be distinguished by the expression of the killer-cell lectin-like receptor CD161 (KLRB1) [155,156], while Th22 expresses the skin-homing receptor CCR10 [154].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [154]
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- Authors
- Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F.
- Affiliations
- Institute for Research in Biomedicine (CH)
- Corresponding author
- Sallusto, Federica
- Venue
- Nature Immunology
- Published
- 2009-07-05
- Volume
- 10
- Issue
- 8
- Pages
- 857-863
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2082450021
- Cited by
- 1,079
- References
- 53
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 29 · 2023: 48 · 2022: 38 · 2021: 53 · 2020: 64 · 2019: 45 · 2018: 66 · 2017: 68 · 2016: 76 · 2015: 79 · 2014: 111 · 2013: 96 · 2012: 95
- FWCI
- 39.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- IL-22, IL-17, CD4+ T cells, CCR10, CCR6, CCR4, RORγ, T-bet, plasmacytoid dendritic cells, interleukin-6, TNF-α, T cell differentiation, skin inflammation, keratinocytes
- MeSH terms
- Interleukin-22, T-bet Transcription Factor, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Interleukins, Receptors, Thyroid Hormone, Skin, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Retinoic Acid, Interleukin-17, T-Box Domain Proteins, Receptors, CCR4, Receptors, CCR6, Receptors, CCR10, Nuclear Receptor Subfamily 1, Group F, Member 3, In Vitro Techniques
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