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Identification of an Autophagy Defect in Smokers’ Alveolar Macrophages

Monick, Martha M, Powers, Linda S, Walters, Katherine, Lovan, Nina, Zhang, Michael, Gerke, Alicia, Hansdottir, Sif, Hunninghake, Gary W·2010·The Journal of Immunology
DOI 10.4049/jimmunol.1001603PMC PMC3057181
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Abstract

Alveolar macrophages are essential for clearing bacteria from the alveolar surface and preventing microbe-induced infections. It is well documented that smokers have an increased incidence of infections, in particular lung infections. Alveolar macrophages accumulate in smokers’ lungs, but they have a functional immune deficit. In this study, we identify an autophagy defect in smokers’ alveolar macrophages. Smokers’ alveolar macrophages accumulate both autophagosomes and p62, a marker of autophagic flux. The decrease in the process of autophagy leads to impaired protein aggregate clearance, dysfunctional mitochondria, and defective delivery of bacteria to lysosomes. This study identifies the autophagy pathway as a potential target for interventions designed to decrease infection rates in smokers and possibly in individuals with high environmental particulate exposure.

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Metadata

Authors
Monick, M. M., Powers, L. S., Walters, K., Lovan, N., Zhang, M., Gerke, A., Hansdottir, S., & Hunninghake, G. W.
Affiliations
  • Department of Medicine, Carver College of Medicine , Iowa City, IA 52242
  • Office of the Vice President for Research, University of Iowa , Iowa City, IA 52242
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2010-11-01
Volume
185
Issue
9
Pages
5425-5435
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1001603
PMC
PMC3057181
Cited by
214
References
10
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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