The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes
Open accessAbstract
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular bulk degradation pathway that plays critical roles in eliminating intracellular pathogens, presenting endogenous Ags, and regulating T lymphocyte survival and proliferation. In this study, we have investigated the role of autophagy in regulating the endoplasmic reticulum (ER) compartment in T lymphocytes. We found that ER content is expanded in mature autophagy-related protein (Atg) 7-deficient T lymphocytes. Atg7-deficient T cells stimulated through the TCR display impaired influx, but not efflux, of calcium, and ER calcium stores are increased in Atg7-deficient T cells. Treatment with the ER sarco/ER Ca2+-ATPase pump inhibitor thapsigargin rescues the calcium influx defect in Atg7-deficient T lymphocytes, suggesting that this impairment is caused by an intrinsic defect in ER. Furthermore, we found that the stimulation-induced redistribution of stromal interaction molecule-1, a critical event for the store-operated Ca2+ release-activated Ca2+ channel opening, is impaired in Atg7-deficient T cells. Together, these findings indicate that the expanded ER compartment in Atg7-deficient T cells contains increased calcium stores, and the inability of these stores to be depleted causes defective calcium influx in these cells. Our results demonstrate that autophagy plays an important role in maintaining ER and calcium homeostasis in T lymphocytes.
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Cites
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy fights disease through cellular self-digestion
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Induction of autophagy and inhibition of tumorigenesis by beclin 1
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Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
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Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240 · cited 1×
“Atg proteins direct autophagosome formation through two ubiquitin-like pathways (1, 3, 5).”
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A critical role for the autophagy gene Atg5 in T cell survival and proliferation
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“Our previous studies have demonstrated that autophagosome forms in mouse primary T lymphocytes and TCR stimulation promotes autophagy processing (25).”
BackgroundResultInfluentialSelf-citationIn vivo requirement for Atg5 in antigen presentation by dendritic cells
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Cited by
Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
Castillo, E. F., Dekonenko, A., Arko-Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., Delgado-Vargas, M., Timmins, G. S., Bhattacharya, D., Yang, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210500109 · Cited by 454
Autophagy and cellular immune responses
Ma, Y., Galluzzi, L., Zitvogel, L., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.017 · Cited by 447
Smith, M. D., Harley, M. E., Kemp, A. J., Wills, J., Lee, M., Arends, M., von Kriegsheim, A., Behrends, C., & Wilkinson, S. (2018) · Developmental Cell · doi:10.1016/j.devcel.2017.11.024 · Cited by 444
Metadata
- Authors
- Jia, W., Pua, H. H., Li, Q.-J., & He, Y.-W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-01
- Volume
- 186
- Issue
- 3
- Pages
- 1564-1574
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1622766158
- Cited by
- 219
- References
- 9
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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