Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

Neher, Jonas J, Neniskyte, Urte, Zhao, Jing-Wei, Bal-Price, Anna, Tolkovsky, Aviva M, Brown, Guy C·2011·The Journal of Immunology

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  15. Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration
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    Jung‐Hee Ryu, Zhi Wang, Dan Fan, Sung‐Hee Han, Sang-Hwan Do, Zhiyi Zuo · 2016 · Neuroreport
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  27. Neuroimmune and Systemic Manifestations of Neuroinflammation in the Temporomandibular Joint and Related Disorders
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  29. Developmental Neuronal Elimination
    José L. Marín‐Teva, Julio Navascués, Ana Sierra, Michel Mallat · 2014 · Springer eBooks
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  39. Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo)
    J Emmrich, Jonas J. Neher, Philipp Boehm‐Sturm, Matthias Endres, Ulrich Dirnagl, Christoph Harms · 2017 · F1000Research
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  41. Characteristics of jaundice and cholestasis in a Finnish population.
    P. Pasanen, Kaarina P. L. Partanen, P. H. Pikkarainen, E. M. ALHAVA · 1992 · PubMed
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  44. Microgliawererecentlyshowntoplayunexpectedrolesinnormalbraindevelopmentandadultphysiology.Thishasbeguntodramati- cally change our view of these resident "immune" cells. Here, we briefly review topics covered in our 2011 Society for Neuroscience minisymposium "The Role of Microglia in the Healthy Brain." This summary is not meant to be a comprehensive review of microglia physiology,butrathertosharenewresultsandstimulatefurtherresearchintothecellularandmolecularmechanismsbywhichmicroglia …
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  47. Review Article Microglia and ischemic stroke: a double-edged sword
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  48. Studies on caspase signaling in microglia
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    D. Kata · 2017
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    Isabele Fattori Moretti · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  52. Environmental toxicant exposure and Parkinson’s disease: LRRK2 and inflammatory processes
    Zachary Dwyer · 2019
  53. Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
    Debia Wakhloo · 2019
  54. Microglia, TREM2, and Therapeutic Methods of Alzheimer’s Disease
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    智久 鈴木, 悦子 落合, 長利 峯岸, 光夫 古口 · 1996 · 園芸学会雑誌. 別冊, 園芸学会大会研究発表
  56. Single cell genomics for cellular phenotyping: applications in brain disorder
    Aurora Arghir · 2020 · Journal of Cell Identity
  57. A role for LRRK2 and Neuroinflammatory Processes in Multi-Hit Toxicant Models of Parkinson’s Disease
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  58. Therapeutic and immunomodulatory functions of the translocator protein in Alzheimer's disease
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  59. Effect of oxidative stress on microglial activation and iron accumulation
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  60. Serum NOXs and Iron Metabolism Biomarkers in RRMS Patients
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  61. The Impact of Juvenile Microglia Transcriptomics on the Adult Brain Regeneration after Cerebral Ischemia.
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  62. Development of an AAV Vector System for Highly Specific and Efficient Gene Expression in Microglia
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  64. Pathogenic role of CD169+ macrophages in neuronal loss and motor decline in NMO mice
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  65. Additional file 1 of Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases
    Li, Chun Yu, Yang, Tian Mi, Ou, Ru Wei, Wei, Qian Qian, Shang, Hui Fang · 2021 · Figshare
  66. Additional file 2 of Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases
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  67. Microglia at the Forefront: New Insights From the Glial Club South Cone Meeting 2025
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