The Immunologic Release of Constituents from Neutrophil Leukocytes
Abstract
The reaction of rabbit neutrophils with immune complexes induced release of constituents to the external medium. The release which accompanied adherence of neutrophils to immune complexes bound to a nonphagocytosable surface resulted from a direct extrusion of granules to the exterior of the cell. Alkaline phosphatase from the secondary granule was released before constituents of the primary granule and remained at the site of excretion, adherent to the external neutrophil membrane. In contrast, while phagocytosis of particulate complexes stimulated release of materials from the primary granules, alkaline phosphatase was released in only small amounts. A possible mechanism of enzyme release during phagocytosis of large particles was demonstrated to occur by two steps. Degranulation into the phagocytic vacuole was followed by opening of the vacuole during uptake of additional particles. Neutrophils were not lysed during either release process.
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In frustrated phagocytosis, macrophages and foreign body giant cells can release mediators of degradation such as reactive oxygen intermediates, degradative enzymes, and acid into the privileged zone between the cell membrane and biomaterial surface, delaying or reducing immediate buffering or inhibition of these mediators.
“In a process described by Henson as frustrated phagocytosis, macrophages and foreign body giant cells can release mediators of degradation such as reactive oxygen intermediates (ROIs, oxygen free radicals), degradative enzymes, and acid into this privileged zone between the cell membrane and biomaterial surface such that immediate buffering or inhibition of these mediators is delayed or reduced.[”
From Foreign body reaction to biomaterials (2008) · cites this paper as [82]
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- Authors
- Henson, P. M.
- Affiliations
- Scripps Clinic (US)
- Corresponding author
- Henson, Peter M
- ORCID
- Henson, Peter M
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-12-01
- Volume
- 107
- Issue
- 6
- Pages
- 1547-1557
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313307387
- Cited by
- 218
- References
- 0
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- neutrophils, immune complexes, degranulation, alkaline phosphatase, phagocytosis, granule extrusion, neutrophil adhesion, phagosome
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