The DOI matches its Crossref record.
Production of Colony-Stimulating Factor in Mitogen-Stimulated Lymphocyte Cultures
Abstract
The addition of phytohemagglutinin, pokeweed mitogen, concanavalin A or bacterial lipopolysaccharide to mouse spleen cultures strongly stimulated production of colony-stimulating factor (CSF), the humoral regulator of granulopoiesis and macrophage formation. Column-filtered spleen cells depleted of macrophages exhibited similar responses. Cultures of macrophage monolayers failed to produce elevated levels of CSF when stimulated by PHA or PWM. The results suggest that activated T- and B-lymphocytes can both produce significant amounts of CSF, providing a possible mechanism for stimulating macrophage formation in chronic immunologic or inflammatory responses.
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Citations
Cited by
The nature and action of granulocyte-macrophage colony stimulating factors
Burgess, A., & Metcalf, D. (1980) · Blood · doi:10.1182/blood.v56.6.947.947 · Cited by 559
Self-citationZucali, J. R., Dinarello, C. A., Oblon, D. J., Gross, M. A., Anderson, L., & Weiner, R. S. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112512 · Cited by 441
Metcalf, D., Johnson, G., & Burgess, A. (1980) · Blood · doi:10.1182/blood.v55.1.138.138 · Cited by 176
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Metadata
- Authors
- Parker, J. W., & Metcalf, D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-02-01
- Volume
- 112
- Issue
- 2
- Pages
- 502-510
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1524801043
- Cited by
- 206
- References
- 0
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Production of Colony-Stimulating Factor in Mitogen-Stimulated Lymphocyte Cultures. https://app.cochat.ai/papers/10.4049/jimmunol.112.2.502
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- Parker, J. W., & Metcalf, D. (1974). Production of Colony-Stimulating Factor in Mitogen-Stimulated Lymphocyte Cultures. The Journal of Immunology. https://doi.org/10.4049/jimmunol.112.2.502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
