The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.
Open accessAbstract
Granulocyte-macrophage colony-stimulating activity (GM-CSA) can be produced by a variety of normal cell types including mononuclear phagocytes, activated T lymphocytes, endothelial cells, and fibroblasts. Recent evidence shows that a major role of the monocyte-macrophage is the recruitment of environmental cells, i.e., fibroblasts, to produce GM-CSA. In this study we have identified interleukin 1 (IL-1) as a monokine that stimulates fibroblasts to produce and release GM-CSA and prostaglandin E2 (PGE2). Both purified human monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 production. Both forms of IL-1 stimulate fibroblasts to produce GM-CSA and PGE2 in a dose-dependent fashion. The fibroblast-stimulating activity found in monocyte-conditioned medium was completely blocked by anti-IL-1. We conclude that monocytes produce IL-1, and that monocyte-derived IL-1 induces fibroblasts to produce GM-CSA and PGE2.
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Cites
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Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
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Role of tumor microenvironment in tumorigenesis
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Metadata
- Authors
- Zucali, J. R., Dinarello, C. A., Oblon, D. J., Gross, M. A., Anderson, L., & Weiner, R. S.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-06-01
- Volume
- 77
- Issue
- 6
- Pages
- 1857-1863
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2156183673
- Cited by
- 441
- References
- 19
- FWCI
- 27.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. https://app.cochat.ai/papers/10.1172/jci112512
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- Zucali, J. R., Dinarello, C. A., Oblon, D. J., Gross, M. A., Anderson, L., & Weiner, R. S. (1986). Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. Journal of Clinical Investigation. https://doi.org/10.1172/jci112512
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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