Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724 · see citing works

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works

Caspase 8 inhibits programmed necrosis by processing CYLD

O’Donnell, M. A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D. R., & Ting, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2362 · Cited by 494 · see citing works

The origin and application of experimental autoimmune encephalomyelitis

Baxter, A. G. (2007) · Nature reviews. Immunology · doi:10.1038/nri2190 · Cited by 458 · see citing works

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

Coornaert, B., Baens, M., Heyninck, K., Bekaert, T., Haegman, M., Staal, J., Sun, L., Chen, Z. J., Marynen, P., & Beyaert, R. (2008) · Nature Immunology · doi:10.1038/ni1561 · Cited by 437 · see citing works

Differential Requirement for Malt1 in T and B Cell Antigen Receptor Signaling

Ruland, J., Duncan, G. S., Wakeham, A. C., & Mak, T. W. (2003) · Immunity · doi:10.1016/s1074-7613(03)00293-0 · Cited by 391 · see citing works

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

Ruefli-Brasse, A. A., French, D. M., & Dixit, V. M. (2003) · Science · doi:10.1126/science.1090769 · Cited by 381 · see citing works

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

Rebeaud, F., Hailfinger, S., Posevitz‐Fejfár, A., Tapernoux, M., Moser, R., Rueda, D., Gaide, O., Guzzardi, M., Iancu, E. M., Rufer, N., et al. (2008) · Nature Immunology · doi:10.1038/ni1568 · Cited by 313 · see citing works

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Matmati, M., Jacques, P., Maelfait, J., Verheugen, E., Kool, M., Sze, M., Geboes, L., Louagie, E., Guire, C. M., Vereecke, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.874 · Cited by 288 · see citing works

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

Vereecke, L., Sze, M., Guire, C. M., Rogiers, B., Chu, Y., Schmidt‐Supprian, M., Pasparakis, M., Beyaert, R., & Loo, G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092474 · Cited by 278 · see citing works

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

Tavares, R. M., Turer, E. E., Liu, C. L., Advincula, R., Scapini, P., Rhee, L., Barrera, J., Lowell, C. A., Utz, P. J., Malynn, B. A., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.017 · Cited by 271 · see citing works

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

Fontán, L., Yang, C., Kabaleeswaran, V., Volpon, L., Osborne, M. J., Beltrán, E., García, M. A. M., Cerchietti, L. C. A., Shaknovich, R., Yang, S. N., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.11.003 · Cited by 267 · see citing works

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

Kool, M., Loo, G., Waelput, W., Prijck, S. D., Muskens, F., Sze, M., Praet, J. T. V., Branco‐Madeira, F., Janssens, S., Reizis, B., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.013 · Cited by 257 · see citing works

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

Ruan, Q., Kameswaran, V., Zhang, Y., Zheng, S. J., Sun, J., Wang, J., DeVirgiliis, J., Liou, H., Beg, A. A., & Chen, Y. H. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110462 · Cited by 248 · see citing works

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

Hammer, G. E., Turer, E. E., Taylor, K. E., Fang, C. J., Advincula, R., Oshima, S., Barrera, J., Huang, E. J., Hou, B., Malynn, B. A., et al. (2011) · Nature Immunology · doi:10.1038/ni.2135 · Cited by 243 · see citing works

Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines

Hailfinger, S., Nogai, H., Pelzer, C., Jaworski, M., Cabalzar, K., Charton, J. E., Guzzardi, M., Décaillet, C., Grau, M., Dörken, B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105020108 · Cited by 241 · see citing works

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

Nagel, D., Spranger, S., Vincendeau, M., Grau, M., Raffegerst, S. H., Kloo, B., Hlahla, D., Neuenschwander, M., von Kries, J. P., Hadian, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.11.002 · Cited by 235 · see citing works

A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains

Düwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B. G., Ruland, J., Marynen, P., & Krappmann, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803313 · Cited by 233 · see citing works

T‐cell receptor‐induced JNK activation requires proteolytic inactivation of CYLD by MALT1

Staal, J., Driege, Y., Bekaert, T., Demeyer, A., Muyllaert, D., Damme, P. V., Gevaert, K., & Beyaert, R. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.85 · Cited by 221 · see citing works

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

Hilliard, B. A., Mason, N. J., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H., Hunter, C. A., & Chen, Y. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15254 · Cited by 201 · see citing works

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

Loo, G., Lorenzi, R. D., Schmidt, H., Huth, M., Mildner, A., Schmidt‐Supprian, M., Lassmann, H., Prinz, M., & Pasparakis, M. (2006) · Nature Immunology · doi:10.1038/ni1372 · Cited by 197 · see citing works

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

Chu, Y., Vahl, J. C., Kumar, D., Heger, K., Bertossi, A., Wojtowicz, E. E., Soberon, V., Schenten, D., Mack, B., Reutelshöfer, M., et al. (2010) · Blood · doi:10.1182/blood-2010-09-306019 · Cited by 191 · see citing works

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

Hilliard, B. A., Mason, N. J., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H., Hunter, C. A., & Chen, Y. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215254 · Cited by 181 · see citing works

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

O’Connor, R. A., & Anderton, S. M. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.11.016 · Cited by 173 · see citing works

Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells.

Hilliard, B. A., Samoilova, E. B., Liu, T. S., Rostami, A. M., & Chen, Y. (1999) · PubMed · Cited by 160 · see citing works

Experimental Autoimmune Encephalomyelitis in NF-κB- Deficient Mice: Roles of NF-κB in the Activation and Differentiation of Autoreactive T Cells

Hilliard, B. A., Samoilova, E. B., Liu, T.-S. T., Rostami, A. M., & Chen, Y. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2937 · Cited by 142 · see citing works

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

Brüstle, A., Brenner, D., Knobbe-Thomsen, C. B., Lang, P. A., Virtanen, C., Hershenfield, B. M., Reardon, C., Lacher, S. M., Ruland, J., Ohashi, P. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63528 · Cited by 115 · see citing works

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

Staal, J., Bekaert, T., & Beyaert, R. (2010) · Cell Research · doi:10.1038/cr.2010.168 · Cited by 108 · see citing works

Mechanism and specificity of the human paracaspase MALT1

Hachmann, J., Snipas, S. J., van Raam, B. J., Cancino, E. M., Houlihan, E. J., Poręba, M., Kasperkiewicz, P., Drąg, M., & Salvesen, G. S. (2012) · Biochemical Journal · doi:10.1042/bj20120035 · Cited by 93 · see citing works

The NF-κB Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

Chen, G., Hardy, K., Pagler, E., Ma, L., Lee, S., Gerondakis, S., Daley, S. R., & Shannon, M. F. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101757 · Cited by 93 · see citing works

Proteasome inhibitors impair RANKL‐induced NF‐κB activity in osteoclast‐like cells via disruption of p62, TRAF6, CYLD, and IκBα signaling cascades

Ang, E. S. M., Pavlos, N. J., Rea, S. L., Qi, M., Chai, T., Walsh, J. P., Ratajczak, T., Zheng, M., & Xu, J. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21787 · Cited by 69 · see citing works

Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

Dann, A., Poeck, H., Croxford, A. L., Gaupp, S., Kierdorf, K., Knust, M., Pfeifer, D., Maihöfer, C., Endres, S., Kalinke, U., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2964 · Cited by 64 · see citing works

IκB Kinase 2/β Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis

Greve, B., Weissert, R., Hamdi, N., Bettelli, E., Sobel, R. A., Coyle, A. J., Kuchroo, V. K., Rajewsky, K., & Schmidt‐Supprian, M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.179 · Cited by 50 · see citing works

Loss of Braking Signals During Inflammation

Gilli, F. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.32 · Cited by 46 · see citing works

Genome-wide association studies in multiple sclerosis: lessons and future prospects

Kemppinen, A., Sawcer, S. J., & Compston, A. (2011) · Briefings in Functional Genomics · doi:10.1093/bfgp/elr004 · Cited by 26 · see citing works

Neutral protease activity in lymphocytes of lewis rats with acute experimental allergic encephalomyelitis

Smith, M. E. (1979) · Neurochemical Research · doi:10.1007/bf00964466 · Cited by 24 · see citing works

NF-κB signaling in inflammation

Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works

Prospects for combining targeted and conventional cancer therapy with immunotherapy

Gotwals, P. J., Cameron, S. B., Cipolletta, D., Cremasco, V., Crystal, A., Hewes, B., Mueller, B., Quaratino, S., Sabatos-Peyton, C. A., Petruzzelli, L., et al. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.17 · Cited by 948 · see citing works

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.030 · Cited by 329 · see citing works

Sjögren Syndrome‐associated lymphomas: an update on pathogenesis and management

Nocturne, G., & Xavier Mariette, A. (2014) · British Journal of Haematology · doi:10.1111/bjh.13192 · Cited by 296 · see citing works

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

Jeltsch, K. M., Hu, D., Brenner, S., Zöller, J., Heinz, G. A., Nagel, D., Vogel, K. U., Rehage, N., Warth, S. C., Edelmann, S. L., et al. (2014) · Nature Immunology · doi:10.1038/ni.3008 · Cited by 274 · see citing works

CARD–BCL-10–MALT1 signalling in protective and pathological immunity

Ruland, J., & Hartjes, L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0087-2 · Cited by 196 · see citing works

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Guire, C. M., Prinz, M., Beyaert, R., & Loo, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.001 · Cited by 154 · see citing works

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

Jaworski, M., Marsland, B. J., Gehrig, J., Held, W., Favre, S., Luther, S. A., Perroud, M., Golshayan, D., Gaide, O., & Thome, M. (2014) · The EMBO Journal · doi:10.15252/embj.201488987 · Cited by 148 · see citing works

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

Bornancin, F., Renner, F., Touil, R., Sic, H., Kolb, Y., Touil, I., Rush, J. S., Smith, P. A., Bigaud, M., Junker, U., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402254 · Cited by 132 · see citing works

GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis

Xia, X., Cao, G., Sun, G., Zhu, L., Tian, Y., Song, Y., Guo, C., Wang, X., Zhong, J., Zhou, W., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129269 · Cited by 120 · see citing works

The paracaspase MALT1: biological function and potential for therapeutic inhibition

Jaworski, M., & Thome, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2059-z · Cited by 109 · see citing works

NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?

Roberti, A., Chaffey, L., & Greaves, D. R. (2022) · Biology · doi:10.3390/biology11030372 · Cited by 103 · see citing works

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

Yu, J. W., Hoffman, S., Beal, A. M., Dykon, A., Ringenberg, M. A., Hughes, A. C., Dare, L. C., Anderson, A. D., Finger, J. N., Kasparcova, V., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127083 · Cited by 93 · see citing works

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation

Cho, J. J., Xu, Z., Parthasarathy, U., Drashansky, T. T., Helm, E. Y., Zuniga, A. N., Lorentsen, K. J., Mansouri, S., Cho, J. Y., Edelmann, M. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08605-3 · Cited by 91 · see citing works

Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling

Juilland, M., & Thome, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01927 · Cited by 88 · see citing works

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

Schlauderer, F., Lammens, K., Nagel, D., Vincendeau, M., Eitelhuber, A. C., Verhelst, S. H. L., Kling, D., Chruściel, A., Ruland, J., Krappmann, D., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201304290 · Cited by 87 · see citing works

MALT 1 – a universal soldier: multiple strategies to ensure NF ‐κB activation and target gene expression

Afonina, I. S., Elton, L., Carpentier, I., & Beyaert, R. (2015) · FEBS Journal · doi:10.1111/febs.13325 · Cited by 82 · see citing works

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Guire, C. M., Elton, L., Wieghofer, P., Staal, J., Voet, S., Demeyer, A., Nagel, D., Krappmann, D., Prinz, M., Beyaert, R., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-124 · Cited by 82 · see citing works

Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome

Meininger, I., & Krappmann, D. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0216 · Cited by 76 · see citing works

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

Demeyer, A., Staal, J., & Beyaert, R. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.12.004 · Cited by 72 · see citing works

MALT 1 cleaves the E3 ubiquitin ligase HOIL ‐1 in activated T cells, generating a dominant negative inhibitor of LUBAC ‐induced NF ‐κB signaling

Elton, L., Carpentier, I., Staal, J., Driege, Y., Haegman, M., & Beyaert, R. (2015) · FEBS Journal · doi:10.1111/febs.13597 · Cited by 69 · see citing works

MALT1 is an intrinsic regulator of regulatory T cells

Brüstle, A., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., Lang, P. A., Lang, K. S., & Mak, T. W. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.104 · Cited by 61 · see citing works

The role of the ubiquitin-editing enzyme A20 in diseases of the central nervous system and other pathological processes

Abbasi, A., Forsberg, K., & Bischof, F. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00021 · Cited by 51 · see citing works

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology

Martin, K., Junker, U., Tritto, E., Sutter, E., Rubic-Schneider, T., Morgan, H., Niwa, S., Li, J., Schlapbach, A., Walker, D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00745 · Cited by 45 · see citing works

Activity-Based Probes for Detection of Active MALT1 Paracaspase in Immune Cells and Lymphomas

Eitelhuber, A. C., Vosyka, O., Nagel, D., Bognar, M., Lenze, D., Lammens, K., Schlauderer, F., Hlahla, D., Hopfner, K., Lenz, G., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.10.021 · Cited by 44 · see citing works

The Paracaspase MALT1

Hachmann, J., & Salvesen, G. S. (2015) · Biochimie · doi:10.1016/j.biochi.2015.09.018 · Cited by 42 · see citing works

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner

Demeyer, A., Skordos, I., Driege, Y., Kreike, M., Hochepied, T., Baens, M., Staal, J., & Beyaert, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01898 · Cited by 42 · see citing works

Recent Advances in Activity-Based Protein Profiling of Proteases

Chakrabarty, S., Kahler, J. P., van de Plassche, M. A. T., Vanhoutte, R., & Verhelst, S. H. L. (2018) · Current topics in microbiology and immunology · doi:10.1007/82_2018_138 · Cited by 40 · see citing works

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells.

Lork, M., Staal, J., & Beyaert, R. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2018.11.001 · Cited by 39 · see citing works

Regulation of T cell signaling and autoimmunity by RNA-binding proteins

Jeltsch, K. M., & Heissmeyer, V. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.011 · Cited by 39 · see citing works

MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies

Liang, X., Cao, Y.-C., Li, C., Yu, H., Yang, C., & Liu, H. S. (2021) · Medicinal Research Reviews · doi:10.1002/med.21799 · Cited by 34 · see citing works

Post‐transcriptional control of immune responses and its potential application

Yoshinaga, M., & Takeuchi, O. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1063 · Cited by 31 · see citing works

MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging

Demeyer, A., Nuffel, E. V., Baudelet, G., Driege, Y., Kreike, M., Muyllaert, D., Staal, J., & Beyaert, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02330 · Cited by 28 · see citing works

Molecular Pathways: Targeting MALT1 Paracaspase Activity in Lymphoma

Fontán, L., & Melnick, A. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3869 · Cited by 27 · see citing works

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity

Schlapbach, A., Révész, L., Pissot‐Soldermann, C., Zoller, T., Régnier, C. H., Bornancin, F., Radimerski, T., Blank, J., Schuffenhauer, A., Renatus, M., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.05.017 · Cited by 25 · see citing works

Development of new Malt1 inhibitors and probes

Xin, B., Schimmack, G., Du, Y. L., Florea, B. I., van der Marel, G. A., Driessen, C., Krappmann, D., & Overkleeft, H. S. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.03.035 · Cited by 24 · see citing works

Regulation of T cell differentiation and function by ubiquitin-specific proteases

Wang, A., Zhu, F., Liang, R., Li, D., & Li, B. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103922 · Cited by 23 · see citing works

A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis

Dumont, C., Sivars, U., Andreasson, T., Odqvist, L., Mattsson, J., DeMicco, A., Pardali, K., Johansson, G., Yrlid, L., Cox, R. J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0222548 · Cited by 22 · see citing works

In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression

Montero‐Calle, A., López‐Janeiro, Á., Mendes, M. L., Pérez-Hernández, D., Echevarría, I., Ruz‐Caracuel, I., Heredia-Soto, V., Mendiola, M., Hardisson, D., Argüeso, P., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00778-w · Cited by 22 · see citing works

The deubiquitinase A20 in immunopathology of autoimmune diseases

Majumdar, I., & Paul, J. (2014) · Autoimmunity · doi:10.3109/08916934.2014.900756 · Cited by 20 · see citing works

Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells

Biswas, S., Chalishazar, A., Helou, Y. A., DiSpirito, J. R., DeChristopher, B. A., Chatterjee, D., Merselis, L. C., Vincent, B. G., Monroe, J. G., Rabah, D., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.875320 · Cited by 19 · see citing works

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain

Kip, E., Staal, J., Verstrepen, L., Tima, H. G., Terryn, S., Romano, M., Lemeire, K., Suin, V., Hamouda, A., Kalai, M., et al. (2018) · Journal of Virology · doi:10.1128/jvi.02029-17 · Cited by 19 · see citing works

Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase

Hailfinger, S., Lenz, G., & Thome, M. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.09.025 · Cited by 18 · see citing works

CARD11 signaling in regulatory T cell development and function

Carter, N. M., & Pomerantz, J. L. (2022) · Advances in Biological Regulation · doi:10.1016/j.jbior.2022.100890 · Cited by 17 · see citing works

Deletion of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis

Gilis, E., Gaublomme, D., Staal, J., Venken, K., Dhaenens, M., Lambrecht, S., Coudenys, J., Decruy, T., Schryvers, N., Driege, Y., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41029 · Cited by 16 · see citing works

Malt1 blocks IL-1β production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo

Monajemi, M., Pang, Y. C. F., Bjornson, S., Menzies, S. C., van Rooijen, N., & Sly, L. M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3vma0118-019r · Cited by 14 · see citing works

Inhibition of MALT1 Decreases Neuroinflammation and Pathogenicity of Virulent Rabies Virus in Mice

Kip, E., Staal, J., Tima, H. G., Verstrepen, L., Romano, M., Lemeire, K., Suin, V., Hamouda, A., Baens, M., Libert, C., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00720-18 · Cited by 13 · see citing works

Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency

Monajemi, M., Fisk, S., Pang, Y. C. F., Leung, J., Menzies, S. C., Ben-Othman, R., Cai, B., Kollmann, T. R., Rozmus, J., & Sly, L. M. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.5vma0219-054r · Cited by 12 · see citing works

Preserving immune homeostasis with A20

Razani, B., Malynn, B. A., & Ma, A. I. (2020) · Advances in immunology · doi:10.1016/bs.ai.2020.10.001 · Cited by 9 · see citing works

RelB regulates Th17 differentiation in a cell-intrinsic manner

Koliesnik, I. O., Andreas, N., Romanov, V. S., Sreekantapuram, S., Krljanac, B., Haenold, R., & Weih, F. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.10.026 · Cited by 10 · see citing works

MALT1 protease: equilibrating immunity versus tolerance

Bertossi, A., & Krappmann, D. (2014) · The EMBO Journal · doi:10.15252/embj.201490217 · Cited by 8 · see citing works

Translational utility of experimental autoimmune encephalomyelitis: recent developments

Jagodic, M., Guerreiro‐Cacais, A. O., Lindahl, H., Flytzani, S., N’diaye, M., & Olsson, T. P. (2015) · Journal of Inflammation Research · doi:10.2147/jir.s76707 · Cited by 6 · see citing works

Immune Regulation by Ubiquitin Tagging as Checkpoint Code

Zeng, P., Ma, J., Yang, R., & Liu, Y. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_64 · Cited by 6 · see citing works

Targeting paracaspase1 (MALT1) for cancer therapy: Updated progress and study on structure-activity relationships (SARs)

Li, Y., Hong, Y., Zhang, J., & Xu, S. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118372 · Cited by 5 · see citing works

Cardiac output quantification by Doppler echocardiography in intensive care--limitations and validation.

Martins, S. R., Soares, R. M., Abreu, J., Branco, L., Salomão, S. L., & Antunes, A. M. (2000) · PubMed · Cited by 5 · see citing works

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibition alleviates intestinal impairment induced by chronic heat stress in finisher broilers

Zhang, H., Pertiwi, H., Majdeddin, M., & Michiels, J. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103252 · Cited by 4 · see citing works

Chemical Probes for Profiling of MALT1 Protease Activity

Verhelst, S. H. L., & Prothiwa, M. (2023) · ChemBioChem · doi:10.1002/cbic.202300444 · Cited by 4 · see citing works

Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts

Govender, L., Mikulic, J., Wyss, J.-C., Gaide, O., Thome, M., & Golshayan, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576651 · Cited by 3 · see citing works

Germinating MALT1

Cain, C. (2014) · Science-Business eXchange · doi:10.1038/scibx.2014.133 · Cited by 2 · see citing works

Detection of Recombinant and Cellular MALT1 Paracaspase Activity

Nagel, D., & Krappmann, D. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2422-6_13 · Cited by 2 · see citing works

Strukturelle Analyse von Phenothiazin‐Derivaten als allosterische Inhibitoren der MALT1‐Paracaspase

Schlauderer, F., Lammens, K., Nagel, D., Vincendeau, M., Eitelhuber, A. C., Verhelst, S. H. L., Kling, D., Chruściel, A., Ruland, J., Krappmann, D., et al. (2013) · Angewandte Chemie · doi:10.1002/ange.201304290

Effector T and B Cell Responses Leading to Results in Unbalanced Regulatory and Deficiency of MALT1 Paracaspase Activity

Patel, D. D., Calzascia, T., Régnier, C. H., Mak, T. W., Ohashi, P. S., Zamurovic, N., McCoy, K. D., Rolink, A. G., Brenner, D., Brüstle, A., et al. (2015)

The mandible's connected to the temporal bone, the temporal bone's connected to the....

Db, J. (1991) · PubMed

MALT1 Deficiency

Nelson, R. P. (2020) · Springer eBooks · doi:10.1007/978-1-4614-9209-2_105-1

MALT1 Deficiency

Nelson, R. P. (2020) · Springer eBooks · doi:10.1007/978-1-4614-8678-7_105

Étude moléculaire de l'inflammation chronique dans la maladie de Parkinson

Compagnion, A. (2019) · theses.fr (ABES) · doi:10.70675/04ca138dz3131z4e24z884czbba2f7954a99

Elucidating the Vulnerability of Glioblastoma Stem-like Cells to Lysosomal Dysfunctions

Maghe, C. (2023) · doi:10.70675/cb5da8bdzc225z4cf1z80a7zeb24afa442f9

BindingDB Entry 50001242: N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

BindingDB (2020) · UC San Diego · doi:10.7270/q2g73h89

BindingDB Entry 50047593: Development of new Malt1 inhibitors and probes.

BindingDB (2017) · UC San Diego · doi:10.7270/q21g0p58

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Guire, C. M., Elton, L., Wieghofer, P., Staal, J., Voet, S., Demeyer, A., Nagel, D., Krappmann, D., Prinz, M., Beyaert, R., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-124 · Cited by 82 · see citing works

Deficiency in MALT1 paracaspase activity promotes multi-organ inflammation

Bornancin, F., Renner, F., Touil, R., Kolb, Y., Touil, I., Rush, J. S., Smith, P., Bigaud, M., Zamurovic, N., Walker, U. J., et al. (2015)

Caspase-1 Regulates the Inflammatory Process Leading to Autoimmune Demyelination

Furlan, R., Martino, G., Galbiati, F., Poliani, P. L., Smiroldo, S., Bergami, A., Desina, G., Comı, G., Flavell, R. A., Su, M. S. S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2403 · Cited by 194 · see citing works

Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity

Skordos, I., Gilis, E., Callewaert, C., Aidarova, A., Haegman, M., Driege, Y., Kreike, M., Afonina, I. S., Staal, J., Demeyer, A., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00814-4

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

Bornancin, F., Renner, F., Touil, R., Sic, H., Kolb, Y., Touil, I., Rush, J. S., Smith, P. A., Bigaud, M., Junker, U., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402254 · Cited by 132 · see citing works