TGF-β1 Limits the Onset of Innate Lung Inflammation by Promoting Mast Cell–Derived IL-6

Ganeshan, Kirthana; Johnston, Laura K; Bryce, Paul J

doi:10.4049/jimmunol.1203362

TGF-β1 Limits the Onset of Innate Lung Inflammation by Promoting Mast Cell–Derived IL-6

TGF-β1 is an important suppressive mediator of inflammation, but it can also drive fibrosis and remodeling in the lung. In response to intratracheal LPS, neutrophils migrate into the lung, and TGF-β1 was suggested to protect against the ensuing injury. However, the mechanisms for this protective …