The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation
Open accessAbstract
Interleukin 6 (IL6) plays key roles in hematopoiesis, immune, and acute phase responses. Dysregulated IL6 expression is implicated in diseases such as atherosclerosis and arthritis. We have examined the functional effect of four polymorphisms in the IL6 promoter (-597G-->A, -572G-->C, -373A(n)T(n), -174G-->C) by identifying the naturally occurring haplotypes and comparing their effects on reporter gene expression. The results indicate different transcriptional regulation in the ECV304 cell line compared with the HeLa cell line, suggesting cell type-specific regulation of IL6 expression. The haplotypes showed functional differences in the ECV304 cell line; transcription was higher from the GG9/11G haplotype and lower from the AG8/12G allele. The differences suggest that more than one of the polymorphic sites is functional; the base differences at distinct polymorphic sites do not act independently of one another, and one polymorphism influences the functional effect of variation at other polymorphic sites. These results show that genetic polymorphisms in the promoter influence IL6 transcription not by a simple additive mechanism but rather through complex interactions determined by the haplotype.
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Cited by
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Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
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Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
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IL-6 in autoimmune disease and chronic inflammatory proliferative disease
Ishihara, K., & Hirano, T. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00027-8 · Cited by 807
Liuzzi, J. P., Lichten, L. A., Rivera, S., Blanchard, R. K., Aydemir, T. B., Knutson, M. D., Ganz, T., & Cousins, R. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502257102 · Cited by 594
Metadata
- Authors
- Terry, C. F., Loukaci, V., & Green, F. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 275
- Issue
- 24
- Pages
- 18138-18144
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2003165120
- Cited by
- 800
- References
- 38
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Terry, C. F., Loukaci, V., & Green, F. R. (2000). Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m000379200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
