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A monoclonal antibody reactive with human peripheral blood monocytes.
Abstract
A monoclonal antibody directed at a determinant on human peripheral blood monocytes was produced and characterized. This hybridoma antibody, termed OKM1, was reactive by indirect immunofluorescence and complement- (C) mediated lysis with adherent mononuclear cells. OKM1 was unreactive with lymphocytes, thymocytes, lymphoblastoid cell lines, and tumor cells of the T or B cell lineage. In contrast, acute myelomonocytic leukemia cells and granulocytes were reactive with the antibody. Pretreatment of peripheral blood mononuclear cells with OKM1 and C before culture with soluble antigens totally abolished their antigen-induced proliferative response. This function was restored by addition of 1% adherent cells. These findings provided additional support for the notion that OKM1 was reactive with monocytes. In addition, OKM1 appeared to define two distinct populations of monocytes; an adherent population of large cells bearing surface Ia determinants and a nonadherent population of small, Ia-negative cells. These OKM1+ Ia- cells were found to be a contaminant of most fractionated mononuclear cell subsets including the E-SIg-Null cell population.
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Citations
Cited by
Biology of Natural Killer Cells
Trinchieri, G. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60664-1 · Cited by 2,902
Sanchez-Madrid, F., Nagy, J. A., Robbins, E., Simon, P., & Springer, T. A. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.6.1785 · Cited by 873
Sutherland, R., Delia, D., Schneider, C., Newman, R., Kemshead, J., & Greaves, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4515 · Cited by 685
A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b/CD18
Moyle, M., Foster, D. L., McGrath, D. E., Brown, S. M., Laroche, Y., De Meutter, J., Stanssens, P., Bogowitz, C. A., Fried, V. A., & Ely, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36982-x · Cited by 253
Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.
Backé, E., Schwarting, R., Gerdes, J., Ernst, M., & Stein, H. (1991) · Journal of Clinical Pathology · doi:10.1136/jcp.44.11.936 · Cited by 92
Metadata
- Authors
- Breard, J., Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-04-01
- Volume
- 124
- Issue
- 4
- Pages
- 1943-1948
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1924778996
- Cited by
- 829
- References
- 0
- FWCI
- 137.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A monoclonal antibody reactive with human peripheral blood monocytes. https://app.cochat.ai/papers/10.4049/jimmunol.124.4.1943
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- Breard, J., Reinherz, E. L., Kung, P. C., Goldstein, G., & Schlossman, S. F. (1980). A monoclonal antibody reactive with human peripheral blood monocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.124.4.1943
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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