The DOI matches its Crossref record.
In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors.
Abstract
A method has been developed for isolating and growing lymphoid cells infiltrating murine solid tumors. When tumor cell suspensions are placed in T cell growth factor (TCGF) lymphoid cells and not tumor cells proliferate. By 7 to 9 days lymphoid cells free of tumor can be harvested and grown continuously in TCGF. The growth of these cells is dependent on the presence of TCGF but not on the presence of concanavalin-A. Tumor cell suspensions that have been freed of T lymphoid cells by treatment with anti-Thy-1.2 serum and complement or by fractionation on Ficoll gradients exhibit no cell out-growth in TCGF. The lymphoid cells growing in TCGF exhibit significant cytotoxicity for syngeneic tumor cells and normal fibroblasts grown in culture but do no lyse normal lymphoid cells.
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Cited by
Rosenberg, S. A., Packard, B. S., Aebersold, P. M., Solomon, D., Topalian, S. L., Toy, S. T., Simon, P., Lotze, M. T., Yang, J. C., Seipp, C. A., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812223192527 · Cited by 2,389
Self-citationMulé, J. J., Shu, S., Schwarz, S. L., & Rosenberg, S. A. (1984) · Science · doi:10.1126/science.6332379 · Cited by 688
Self-citationA history of exploring cancer in context
Maman, S., & Witz, I. P. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0006-7 · Cited by 502
Mazumder, A., & Rosenberg, S. A. (1984) · The Journal of experimental medicine · doi:10.1084/jem.159.2.495 · Cited by 369
Self-citationLymphokine-activated killer cells: A new approach to immunotherapy of cancer
(1985) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/75.4.595 · Cited by 308
Metadata
- Authors
- Yron, I., Wood, T. A., Spiess, P. J., & Rosenberg, S. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-07-01
- Volume
- 125
- Issue
- 1
- Pages
- 238-245
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2102251060
- Cited by
- 264
- References
- 0
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors. https://app.cochat.ai/papers/10.4049/jimmunol.125.1.238
- The paper
- Yron, I., Wood, T. A., Spiess, P. J., & Rosenberg, S. A. (1980). In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors. The Journal of Immunology. https://doi.org/10.4049/jimmunol.125.1.238
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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