The DOI matches its Crossref record.
Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis.
Abstract
Lymphocyte proliferative responses to mitogens and herpes virus antigens are diminished during cytomegalovirus (CMV) mononucleosis. We analyzed peripheral blood T lymphocytes from patients in the acute and convalescent phases of CMV mononucleosis using monoclonal antibodies directed against the T helper and the T cytotoxic-suppressor cell subsets. Acute CMV infection is associated with a reversal in the normal ratio of helper to suppressor T lymphocytes with relative and absolute decreases in T helper cells and corresponding increases in T suppressor cells. These alterations in T lymphocyte subsets are accompanied by diminished lymphocyte responses to the mitogen concanavalin A (Con A). During convalescence, helper T lymphocytes increase, suppressor T lymphocytes decrease, and Con A responses return to normal.
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Cited by
Gottlieb, M. S., Schroff, R., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,728
ACUTE AIDS RETROVIRUS INFECTION
Cooper, D., Maclean, P., Finlayson, R., Michelmore, H., Gold, J., Donovan, B., Barnes, T., Brooke, P., & Penny, R. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91205-x · Cited by 709
Herpesvirus Infections in the Acquired Immune Deficiency Syndrome
Quinnan, G. V. (1984) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1984.03350010038020 · Cited by 398
Opportunistic Infections and Immune Deficiency in Homosexual Men
MILDVAN, D., MATHUR, U., ENLOW, R. W., ROMAIN, P. L., WINCHESTER, R. J., COLP, C., SINGMAN, H., ADELSBERG, B. R., & SPIGLAND, I. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-6-700 · Cited by 377
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Durack, D. T. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052408 · Cited by 288
Metadata
- Authors
- Carney, W. P., Rubin, R. H., Hoffman, R. A., Hansen, W. P., Healey, K., & Hirsch, M. S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-06-01
- Volume
- 126
- Issue
- 6
- Pages
- 2114-2116
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1529201377
- Cited by
- 477
- References
- 0
- FWCI
- 64.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carney, W. P., Rubin, R. H., Hoffman, R. A., Hansen, W. P., Healey, K., & Hirsch, M. S. (1981). Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.126.6.2114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
