The DOI matches its Crossref record.
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.
Abstract
Mice of 12 inbred strains infected i.v. with Mycobacterium bovis (BCG) exhibited 2 distinct patterns of response as determined by the degree of BCG burden in the spleens of animals at 3 wk after infection with 10(4) viable bacilli: susceptible (C57BL/6J and related sublines, BALB/c and DBA/1J) and resistant (A/J, C3H/HeCr, DBA/2J, CBA/J, C57Br, AKR). Mendelian analysis of this trait on segregating backcross and F2 populations derived from the mating of resistant and susceptible progenitors was compatible with the hypothesis that resistance to BCG is controlled by a single, dominant, autosomal gene, which is being given the designation Bcg. The product of the Bcg gene was found to influence the early phase of host response resulting in the genetic advantage of the resistant host being demonstrable as early as 24 hr after infection.
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Citations
Cited by
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104
Self-citationVidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
Self-citationGruenheid, S., Pinner, E., Desjardins, M., & Gros, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.717 · Cited by 428
Self-citationIdentification and characterization of a second mouse Nramp gene
Gruenheid, S., Cellier, M., Vidal, S., & Gros, P. (1995) · Genomics · doi:10.1016/0888-7543(95)80053-o · Cited by 287
Self-citationvan der Laan, L. J. W., Döpp, E. A., Haworth, R., Pikkarainen, T., Kangas, M., Elomaa, O., Dijkstra, C. D., Gordon, S., Tryggvason, K., & Kraal, G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.939 · Cited by 280
Metadata
- Authors
- Gros, P., Skamene, E., & Forget, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-12-01
- Volume
- 127
- Issue
- 6
- Pages
- 2417-2421
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1962419639
- Cited by
- 342
- References
- 0
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. https://app.cochat.ai/papers/10.4049/jimmunol.127.6.2417
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- Gros, P., Skamene, E., & Forget, A. (1981). Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. The Journal of Immunology. https://doi.org/10.4049/jimmunol.127.6.2417
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
