The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Regulation and Functional Involvement of Macrophage Scavenger Receptor MARCO in Clearance of Bacteria In Vivo
Abstract
The scavenger receptors expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating binding and phagocytosis. A novel member of the class A scavenger receptor family, macrophage receptor with collagenous structure (MARCO), has recently been identified. In this study we have generated a panel of mAbs with specificities for different domains of this receptor. Two of those reacting with the C-terminal cysteine-rich domain block ligand binding of MARCO. The in vivo expression of this murine receptor is normally restricted to distinct populations of macrophages in the spleen and lymph nodes. During bacillus Calmette-Guérin (BCG) infection, during bacterial sepsis, or after the injection of purified LPS, however, the expression of MARCO is rapidly induced on macrophages in other tissues, including Kupffer cells in the liver. Using the mouse macrophage cell line J774.2, it was shown that LPS stimulation up-regulates surface expression of MARCO in a dose- and time-dependent fashion. The proinflammatory cytokines IL-1, IL-6, TNF-α, and IFN-γ had little or no effect. Using inhibitory mAbs, the relevance of MARCO for the clearance of circulating bacteria in vivo was determined. Although the overall elimination of live Escherichia coli and Staphylococcus aureus from the blood did not appear to be affected by treatment with these Abs, the capturing of heat-killed bacteria by macrophages in the marginal zone areas of the spleen was clearly inhibited. This study suggests a role for MARCO in the host antibacterial defense.
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Cites
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,719
Innate immunity: impact on the adaptive immune response
Medzhitov, R., & Janeway, C. A. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80152-5 · Cited by 1,558
The immune system evolved to discriminate infectious nonself from noninfectious self
Janeway, C. A. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90198-g · Cited by 1,342
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,224
Self-citationKrieger, M., & Krieger, J. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.003125 · Cited by 1,160
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Kodama, T., Freeman, M., Rohrer, L., Zabrecky, J., Matsudaira, P., & Krieger, M. (1990) · Nature · doi:10.1038/343531a0 · Cited by 1,041
CD14 Is a pattern recognition receptor
Pugin, J., Heumann, D., Tomasz, A., Kravchenko, V. V., Akamatsu, Y., Nishijima, M., Glauser, M. P., Tobias, P. S., & Ulevitch, R. J. (1994) · Immunity · doi:10.1016/1074-7613(94)90093-0 · Cited by 699
Bhattacharya, A., Dorf, M. E., & Springer, T. A. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.6.2488 · Cited by 525
Recognition and plasma clearance of endotoxin by scavenger receptors
Hampton, R. Y., Golenbock, D. T., Penman, M., Krieger, M., & Raetz, C. R. H. (1991) · Nature · doi:10.1038/352342a0 · Cited by 524
Elomaa, O., Kangas, M., Sahlberg, C., Tuukkanen, J., Sormunen, R., Liakka, A., Thesleff, I., Kraal, G., & Tryggvason, K. (1995) · Cell · doi:10.1016/0092-8674(95)90514-6 · Cited by 514
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Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Self-citationPhagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis
Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927
Phagocytosis: Our Current Understanding of a Universal Biological Process
Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
Nguyen, P. T., Dorman, L. C., Pan, S., Vainchtein, I. D., Han, R. T., Nakao-Inoue, H., Taloma, S. E., Barron, J. J., Molofsky, A. B., Kheirbek, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.050 · Cited by 615
Metadata
- Authors
- van der Laan, L. J. W., Döpp, E. A., Haworth, R., Pikkarainen, T., Kangas, M., Elomaa, O., Dijkstra, C. D., Gordon, S., Tryggvason, K., & Kraal, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 162
- Issue
- 2
- Pages
- 939-947
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1480188565
- Cited by
- 280
- References
- 39
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- van der Laan, L. J. W., Döpp, E. A., Haworth, R., Pikkarainen, T., Kangas, M., Elomaa, O., Dijkstra, C. D., Gordon, S., Tryggvason, K., & Kraal, G. (1999). Regulation and Functional Involvement of Macrophage Scavenger Receptor MARCO in Clearance of Bacteria In Vivo. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.2.939
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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