The DOI matches its Crossref record.
Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.
Abstract
Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly increased in 13 cases, and in 12 of these the cytotoxic effect of the T lymphocytes was inhibited by preincubating the liver cells with IgG containing antibodies to the hepatitis B core antigen (HBcAg). Normal human IgG and IgG containing antibodies to the hepatitis B surface antigen (HBsAG) were without effect. Control experiments using autologous fibroblasts as target cells showed low levels of T cell cytotoxicity and no blocking effect of anti-core antibody. All patients in whom it was possible to demonstrate HBcAg in liver tissue had significantly increased T cell cytotoxicity to autologous hepatocytes. These studies suggest that T cell cytotoxicity in patients with chronic HBV infection is directed against determinants resembling the hepatitis B core antigen on the plasma membrane of hepatocytes.
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Cited by
Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
Milich, D. R., Jones, J. E., Hughes, J. L., Price, J., Raney, A. K., & McLachlan, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6599 · Cited by 580
Moebius, U., Manns, M., Hess, G., Kober, G., zum Büschenfelde, K. M., & Meuer, S. C. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200426 · Cited by 93
Ramadori, G., Moebius, U., Dienes, H. P., Meuer, S., & Büschenfelde, K. H. M. Z. (1990) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899413 · Cited by 22
Casini, A., Ricci, O. E., Paoletti, F., & Surrenti, C. (1985) · Liver · doi:10.1111/j.1600-0676.1985.tb00228.x · Cited by 22
Metadata
- Authors
- Mondelli, M., Vergani, G. M., Alberti, A., Vergani, D., Portmann, B., Eddleston, A. L., & Williams, R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-12-01
- Volume
- 129
- Issue
- 6
- Pages
- 2773-2778
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1568336135
- Cited by
- 388
- References
- 0
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. https://app.cochat.ai/papers/10.4049/jimmunol.129.6.2773
- The paper
- Mondelli, M., Vergani, G. M., Alberti, A., Vergani, D., Portmann, B., Eddleston, A. L., & Williams, R. (1982). Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.129.6.2773
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
