The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
Open accessAbstract
Infants born to hepatitis B virus carrier mothers, who express a secreted form of the nucleocapsid antigen designated HBeAg, invariably become persistently infected. To investigate the role of immunologic tolerance mechanisms in chronic infection of the newborn, we have generated HBeAg-expressing transgenic mice. HBeAg-expressing transgenic mice were tolerant to both HBeAg and the nonsecreted nucleocapsid (hepatitis B cor antigen/HBcAg) at the T-cell level. Transgenic mice did not produce antibody to HBeAg but did produce anti-HBc antibody in vivo and in vitro. The coexistence of tolerance to HBc/HBe T-cell determinants and anti-HBc antibody production in vivo parallels the immunologic status of neonates born to carrier mothers. It was also demonstrated that the maintenance of T-cell tolerance to HBcAg/HBeAg required the continued presence of the tolerogen and in its absence persisted for less than 16 weeks. The reversibility of T-cell tolerance to HBcAg/HBeAg may explain the inverse correlation between age of infection and rates of viral persistence. These observations suggest that a function of the HBeAg may be to induce immunologic tolerance in utero. Expression of HBeAg may represent a viral strategy to guarantee persistence after perinatal infection.
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Cites
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The Nucleocapsid of Hepatitis B Virus Is Both a T-Cell-Independent and a T-Cell-Dependent Antigen
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Cited by
Pathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection
Huang, L.-R., Wu, H.-L., Chen, P.-J., & Chen, D.-S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608578103 · Cited by 294
Chou, H.-H., Chien, W.-H., Wu, L.-L., Cheng, C.-H., Chung, C.-H., Horng, J.-H., Ni, Y.-H., Tseng, H.-T., Wu, D., Lu, X., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424775112 · Cited by 211
Basuni, A. A., Butterworth, L., Cooksley, G., Locarnini, S., & Carman, W. F. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.01.046 · Cited by 60
Metadata
- Authors
- Milich, D. R., Jones, J. E., Hughes, J. L., Price, J., Raney, A. K., & McLachlan, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-09
- Volume
- 87
- Issue
- 17
- Pages
- 6599-6603
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158541247
- Cited by
- 580
- References
- 14
- FWCI
- 17.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Milich, D. R., Jones, J. E., Hughes, J. L., Price, J., Raney, A. K., & McLachlan, A. (1990). Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.17.6599
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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