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Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.
Abstract
Labeled antigen-binding tests were used to determine quantitatively the contribution of IgG4 antibodies to the total IgG antibody response in humans. In agreement with literature, we found no IgG4-restricted antibody responses with tetanus toxoid or streptococcal carbohydrate. In the serum of individuals immunized for several years with phospholipase (PLA) from honey bee venom, grass pollen allergen, or house dust mite allergen, we often found that more than 50% of the total antigen-binding capacity was due to IgG4 antibodies. In the case of beekeepers, it could clearly be shown that during prolonged immunization a shift in the IgG4:IgG1 antibody ratio occurs that finally results in an IgG4-dominated antibody response. Evidence is provided that antigen-binding assays may even underestimate the contribution of IgG4 antibodies, because in contrast to IgG1 antibodies, IgG4 antibodies act as monovalent antibodies in being unable to cross-link immunosorbent-bound antigen and radiolabeled antigen.
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Citations
Cited by
IgG Subclasses and Allotypes: From Structure to Effector Functions
Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
Boutin, S., Monteilhet, V., Veron, P., Leborgne, C., Benveniste, O., Montus, M. F., & Masurier, C. (2010) · Human Gene Therapy · doi:10.1089/hum.2009.182 · Cited by 970
Jutel, M., Akdis, M., Budak, F., Aebischer‐Casaulta, C., Wrzyszcz, M., Blaser, K., & Akdis, C. A. (2003) · European Journal of Immunology · doi:10.1002/eji.200322919 · Cited by 915
Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis
van Schouwenburg, P. A., Rispens, T., & Wolbink, G. J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.4 · Cited by 438
Immunogenicity to Biotherapeutics – The Role of Anti-drug Immune Complexes
Krishna, M., & Nadler, S. G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00021 · Cited by 389
Metadata
- Authors
- Aalberse, R. C., van der Gaag, R., & van Leeuwen, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-02-01
- Volume
- 130
- Issue
- 2
- Pages
- 722-726
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1641557591
- Cited by
- 736
- References
- 0
- FWCI
- 24.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. https://app.cochat.ai/papers/10.4049/jimmunol.130.2.722
- The paper
- Aalberse, R. C., van der Gaag, R., & van Leeuwen, J. (1983). Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.130.2.722
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
