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Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.
Abstract
Mouse macrophages become activated to kill tumor cells by traversing a series of steps (1-3). The first of these does not cause the expression of cytolytic activity; instead, it primes macrophages to respond to a second signal(s) that then triggers the onset of killing (4-7). The mediator that is responsible for priming is contained, along with other lymphokines, in the culture supernatants of concanavalin A-stimulated spleen cells (5-7) cloned T lymphocytes (8), or some T cell hybridomas (9). Close association has been noted between macrophage priming activity and antiviral activity that is attributable to gamma interferon (10-12). However, unequivocal evidence that the two activities are products of the same molecule has not been available. We now how conclusively by using mouse gamma interferon (MulFN-gamma)3 produced by recombinant DNA technology that, in addition to antiviral activity, this lymphokine has the capacity to induce the priming step in the process of macrophage activation for tumor cell killing.
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Citations
Cited by
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
Immune interferon: a pleiotropic lymphokine with multiple effects
Trinchieri, G., & Perussia, B. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90080-5 · Cited by 658
Metadata
- Authors
- Pace, J. L., Russell, S. W., Torres, B. A., Johnson, H. M., & Gray, P. W.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-05-01
- Volume
- 130
- Issue
- 5
- Pages
- 2011-2013
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1960701436
- Cited by
- 442
- References
- 0
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing. https://app.cochat.ai/papers/10.4049/jimmunol.130.5.2011
- The paper
- Pace, J. L., Russell, S. W., Torres, B. A., Johnson, H. M., & Gray, P. W. (1983). Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing. The Journal of Immunology. https://doi.org/10.4049/jimmunol.130.5.2011
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
