Cited by 4,173Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsGenomics and Chromatin Dynamics

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Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Gerdes, J, Lemke, H, Baisch, H, Wacker, H H, Schwab, U, Stein, H·1984·The Journal of Immunology

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Abstract

The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle. All experiments consistently showed that the Ki-67 nuclear antigen is present in S, G2, and M phase, but is absent in G0. However, the results concerning Ki-67 antigen expression in G1 phase varied: cells passing the early events of mitogen triggered transition from G0 to G1, i.e., G1T and first G1A, lacked the Ki-67 nuclear antigen, whereas G1 cells after mitosis were constantly Ki-67-positive. This result suggests that after mitosis cells might not follow the same metabolic pathways as G0 cells do when entering G1 for the first time. Therefore, we suggest that the early stages of mitogen stimulation represent initial sequences of proliferation and not parts of the cell cycle. Because our data show that the Ki-67 nuclear antigen is present throughout the cell cycle, immunostaining with monoclonal antibody Ki-67 provides a reliable means of rapidly evaluating the growth fraction of normal and neoplastic human cell populations.

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Crossref · 10.4049/jimmunol.133.4.1710

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Are malignant melanoma patients at higher risk for a second cancer?
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Dawson, A., Norton, J. A., & Weinberg, D. S. (1990) · PubMed Central · Cited by 166
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Wohlfart, S., Khalansky, A. S., Gelperina, S. E., Maksimenko, O., Bernreuther, C., Glatzel, M., & Kreuter, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019121 · Cited by 162
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Mackey, A. L., Kjær, M., Charifi, N., Henriksson, J., Bojsen‐Møller, J., Holm, L., & Kadi, F. (2009) · Muscle & Nerve · doi:10.1002/mus.21369 · Cited by 162
Proliferation and differentiation in mammalian airway epithelium
Ayers, M., & Jeffery, P. K. (1988) · European Respiratory Journal · doi:10.1183/09031936.93.01010058 · Cited by 162
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Freese, C., Uboldi, C., Gibson, M. I., Unger, R. E., Weksler, B. B., Romero, I. A., Couraud, P., & Kirkpatrick, C. J. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-23 · Cited by 161
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Wang, S., Yh, L., Hl, P., Hong, X.-W., Zhang, D., Xu, Y.-Y., Yi, T., Wang, Y., Yuan, M.-M., Dj, L., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.112 · Cited by 159
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Shibata, S., Tada, Y., Asano, Y., Hau, C. S., Kato, T., Saeki, H., Yamauchi, T., Kubota, N., Kadowaki, T., & Sato, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101739 · Cited by 160
Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer.
Dutta, A., Chandra, R., Leiter, L. M., & Lester, S. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5386 · Cited by 160
Immunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy
Nisolle, M., Gillerot, S., Casanas‐Roux, F., Squifflet, J. P., Berlière, M., & Donnez, J. (1999) · Human Reproduction · doi:10.1093/humrep/14.11.2844 · Cited by 159
Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
Grijalva, J., Huizenga, M. N., Mueller, K. A., Rodriguez, S., Brazzo, J. A., Camargo, F. D., Sadri‐Vakili, G., & Vakili, K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2014 · Cited by 159
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Hazenberg, M. D., Otto, S. A., de Pauw, E. S. D., Roelofs, H., Fibbe, W. E., Hamann, D., & Miedema, F. F. (2002) · Blood · doi:10.1182/blood.v99.9.3449 · Cited by 161
E-selectin is present in proliferating endothelial cells in human hemangiomas.
Kräling, B. M., RAZON, M. J., Boon, L. M., Zurakowski, D., Seachord, C. L., Darveau, R. P., Mulliken, J. B., Corless, C. L., & Bischoff, J. E. (1996) · Europe PMC (PubMed Central) · Cited by 156
Canine mammary tumors as a model for human disease (Review)
Abdelmegeed, S., & Mohammed, S. I. (2018) · Oncology Letters · doi:10.3892/ol.2018.8411 · Cited by 158
Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: A double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies
Shih, I., & Kurman, R. J. (1998) · Human Pathology · doi:10.1016/s0046-8177(98)90386-0 · Cited by 157
Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells 1
Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., & Suzuki, T. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800505 · Cited by 157
Growth rate of human pituitary adenomas
Landolt, A. M., SHIBATA, T., & Kleihues, P. (1987) · Journal of neurosurgery · doi:10.3171/jns.1987.67.6.0803 · Cited by 157
P53 protein in proliferation, repair and apoptosis of cells
Wawryk‐Gawda, E., Chylińska‐Wrzos, P., Lis-Sochocka, M., Chłapek, K., Bulak, K., Jędrych, M., & Jodłowska‐Jędrych, B. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0548-1 · Cited by 155
Low Proliferation Activity May Be Associated With Chemoresistance in Clear Cell Carcinoma of the Ovary
Itamochi, H., Kigawa, J., Sugiyama, T., Kikuchi, Y., Suzuki, M., & Terakawa, N. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02040-9 · Cited by 155
5-lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death
Anderson, K. M., Seed, T. M., Vos, M. D., Mulshine, J. L., Meng, J., Alrefai, W. A., Ou, D., & Harris, J. E. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19981101)37:3 · Cited by 96
Formation of the Building Plan of the Human Heart
Sizarov, A., Ya, J., de Boer, B. A., Lamers, W. H., Christoffels, V. M., & Moorman, A. F. M. (2011) · Circulation · doi:10.1161/circulationaha.110.980607 · Cited by 154
High Ki67 expression is an independent good prognostic marker in colorectal cancer
Melling, N., Kowitz, C. M., Simon, R., Bokemeyer, C., Terracciano, L., Sauter, G., Izbicki, J. R., & Marx, A. H. (2015) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2015-202985 · Cited by 154
Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation.
Litvinov, S. V., van Driel, W. J., Rhijn, C. M. J., Bakker, H. A. M., van Krieken, J. H., Fleuren, G. J., & Warnaar, S. O. (1996) · Europe PMC (PubMed Central) · Cited by 154
Microwave antigen retrieval in immunocytochemistry: a study of 80 antibodies.
Cuevas, E. C., Bateman, A. C., Wilkins, B. S., Johnson, P. A., Williams, J. H., Lee, A. H., Jones, D. B., & Wright, D. H. (1994) · Journal of Clinical Pathology · doi:10.1136/jcp.47.5.448 · Cited by 153
Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas.
Campo, E., Calle-Martin, O. D. L., Miquel, R., Palacín, A., Romero, M., Fabregat, Vives, J., Cardesa, A., & Yagüe, J. (1991) · PubMed · Cited by 153
Cell cycle regulation of metallothionein in human colonic cancer cells.
Nagel, W. W., & Vallée, B. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.579 · Cited by 151
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Thiebaud, N., Johnson, M. C., Butler, J. L., Bell, G. A., Ferguson, K. L., Fadool, A. R., Fadool, J. C., Gale, A. M., Gale, D. S., & Fadool, D. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3366-13.2014 · Cited by 151
Ki-67 expression is a prognostic marker of prostate cancer recurrence after radical prostatectomy.
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Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAS and proteins in acute cutaneous wounds of healthy humans
Ashcroft, G. S., Kielty, C. M., Horan, M. A., & Ferguson, M. W. J. (1997) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199709)183:1 · Cited by 84
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Steger, K. (1998) · Molecular Human Reproduction · doi:10.1093/molehr/4.3.227 · Cited by 150
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Gillitzer, R., Wolff, K., Castillo‐Tong, D. C., Mueller, C., Yoshimura, T., Hartmann, A., Stingl, G., & Berger, R. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12363613 · Cited by 150
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Grage‐Griebenow, E., Lorenzen, D. R., Fetting, R., Flad, H., & Ernst, M. (1993) · European Journal of Immunology · doi:10.1002/eji.1830231213 · Cited by 150
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Kamel, O. W., LeBrun, D. P., Davis, R. E., Berry, G. J., & Warnke, R. A. (1991) · PubMed Central · Cited by 150
Ki-67 expression during rat liver regeneration after partial hepatectomy
Gerlach, C., Sakkab, D. Y., Scholzen, T. E., Daβler, R., Alison, M. R., & Gerdes, J. (1997) · Hepatology · doi:10.1002/hep.510260307 · Cited by 149
Self-citation
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Jacob, M. C., Favre, M., & Bensa, J. (1991) · Cytometry · doi:10.1002/cyto.990120612 · Cited by 149
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Cameron, R. I., Maxwell, P., Jenkins, D., & McCluggage, W. G. (2002) · Histopathology · doi:10.1046/j.1365-2559.2002.01465.x · Cited by 149
Interphase Nucleolar Organizer Regions in Cancer Cells
Derenzini, M., & Ploton, D. (1991) · International review of experimental pathology · doi:10.1016/b978-0-12-364932-4.50008-3 · Cited by 149
p53 and MDM2 alterations in osteosarcomas
Lonardo, F., Ueda, T., Huvos, A. G., Healey, J. H., & Ladanyi, M. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970415)79:8 · Cited by 147
Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis
Nisolle, M., Casanas-Roux, F., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00341-5 · Cited by 148
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Meaburn, K. J., Cabuy, E., Bonne, G., Lévy, N., Morris, G. E., Novelli, G., Kill, I. R., & Bridger, J. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00270.x · Cited by 155
Histologic features are important prognostic indicators in early stages lung adenocarcinomas
Yim, J. H., Zhu, L., Chiriboga, L. A., Watson, H. N., Goldberg, J. D., & Moreira, A. L. (2006) · Modern Pathology · doi:10.1038/modpathol.3800734 · Cited by 147
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Authors: Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., & Stein, H.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Universität Hamburg (DE)
ORCID: Lemke, H
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1984-10-01
Volume: 133
Issue: 4
Pages: 1710-1715
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.133.4.1710
OpenAlex: W2126486896
Cited by: 4,173
References: 0
Citations by year: 2026: 44 · 2025: 65 · 2024: 90 · 2023: 70 · 2022: 83 · 2021: 105 · 2020: 76 · 2019: 98 · 2018: 93 · 2017: 127 · 2016: 111 · 2015: 114 · 2014: 112 · 2013: 122 · 2012: 101
FWCI: 14.15
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Ki-67, cell proliferation, cell cycle, nuclear antigens, G0 to G1 transition, G1 phase, S phase, G2/M phase, mitogen stimulation, growth fraction, monoclonal antibodies, neoplastic cells
MeSH terms: Animals, Antibodies, Monoclonal, Blood Proteins, Cell Cycle, Cycloheximide, DNA, Humans, Kinetics, Lymphocyte Activation, Lymphocytes, Mitomycins, Nucleoproteins, Phytohemagglutinins, RNA, Mitomycin, Antigens, Nuclear, Mice

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Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

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